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115 Cards in this Set

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bilobate nucleus?
basophils and eosinophils
secrete histamine and heparin?
basophils and mast cells
secrete histaminase?
eosinphils
hypersegmented PMNS?
B12/folate deficiency
neutrophil granule content?
myeloperoxidase--bacterial cell wall
lysozyme--bactericidal
lactoferrin--inhibits bacterial growth
kidney's shaped nucleus, frosted-glass cytoplasm?
monocyte
monocyte-derived osteocytes have __________ but no __________ receptors
calcitonin.........parathyroid
abundant ER and well-developed Gogli?
plasma cell
secretes LTD4 and SRS-A?
basophils
anisocytosis means....
varying SIZES
what does kallikrein do?
make plasmin
make bradykinin
activate factor 12
what do protein C and S do?
inactivate factors 5 and 8
what is associated with SQUAMOUS cell carcinoma of the esophagus?
Plummer-Vinson
what is associated with ADENOcarcinoma of the esphagus?
Barret's esophagus
immunodeficiency states are associated with what neoplasm?
malignant lymphomas
What neoplasms is tuberous sclerosis associated with?
astrocytoma and cardiac rhabdomyoma
Rb tumor suppressor is associated with what 2 tumors?
retinoblastoma, osteosarcoma
ovarian cancer is associated with what oncogene and what tumor suppressor?
oncogene: erb-B2
tumor suppressor: BRCA 1 and 2
tumor suppressor p16, chromosome 9q
melanoma
tumor suppressors for colorectal cancer and colon cancer
APC for coloRECTAL
DCC for colon cancer
besides breast and ovarian, erb-B2 is also found in....
gastric carcinoma
tumor marker for malignant epithelial tumor?
CA-125
(also for ovarian)
alk phos is a tumor marker for what 3 tumors?
mets to bone
obstructive biliary disease
Paget's
S-100 is a tumor marker for what?
melanoma
neural tumors
astrocytoma
bombesin is a tumor marker for?
neuroblastoma
lung and gastic cancer
erythropoetin producing tumors?
renal cell carcinoma
hemangioblastoma (cerebellar hemangioma)
HCC
teardrop cell
myeloid metaplasia and myelofibrosis
acanthocyte
spiny appearance in abetalipoprotienemia
poikilocytes are assoicated with
TTP/HUS
microvascular damage
DIC
Burr cell is associated with
TTP/HUS
ferritin is a measure of...
iron stores.
TIBC is increased in _________ and decreased in _________
iron deficiency anemia.....anemia of chronic disease (normo-) or inflammatory states (micro-).
basophilic stippling is associated with
lead poisoning
what is blood iron carrier?
transferrin. measure by TIBC
marked reticulocytosis in which anemia?
macrocytic
what does serum haptoglobin do?
bind free Hb
low in hemolytic anemia
what is HbH?
LACKS 3 alpha chain
what are the blood dyscrasias?
sickle cell and thalassemias
secondary hemochromatosis in thalassemia patients can lead to
heart failure
increased reticulocytes in...
macrocytic anemia, hemolytic anemia
extravascular hemolysis occurs in what anemias?
autoimmune hemolytic anemia
and
hereditary spherocytosis
where does extravascular hemolysis occur?
spleen and Kupffer cells of liver
increased MCHC and increased RDW?
hereditary spherocytosis
What diseases for warm agglutinins?
lupus
CLL
drugs (alpha-methyl dopa)
what diseases for cold agglutinins?
mycoplasma
mononucleosis
Raynaud's
What is fibronectin?
opsonin for phagocytic material in newly formed clots. (bacteria, other crap)
bite cells are found in...?
G6PD (oxidized Hb forms Heinz body, bit out by spleen)
most common cause of drug-induced thrombocytopenia?
heparin
agranulocytosis means...
leukopenia, especially neutrophils
thrombin time is a more specific measure of...
fibrinogen
bleeding time is a measure of...
platelet dysfunction
low ESR?
polycythemia
sickle cell
CHF
high ESR?
cancer, multiple myeloma
pregnancy
infection
connective tissue disorder (lupus)
skin necrosis from warfarin is due to...
protein C deficiency
(causes thrombosis of microvasculature)
prevents GP IIb/IIIa expression?
clopidogrel and ticlopidine
t(11:14)
mantle cell lymphoma
(muliple myeloma)
(small non-cleaved cell lymphoma)
c-myc is associated with what lymphoma?
Burkitt's
t(8:14)
bcl-2 is associated with what lymphoma?
Follicular lymphoma
t(14:18)
highly phagocytic for antigen-antibody complexes?
eosinophils
thrombomoduline binds thrombing, converting it to....
an activator of protein C
Factor V Leiden mutaiton is resistance to ....
protein C
Psammoma bodies are found in...
papillary (thyroid)
serous (ovary)
meningioma
mesothelioma
cause Lambert Eaton syndrome
thymoma
small cell lung cancer
increased megakaryocytes?
ITP
myeloid metaplasia and myelofibrosis
presents with mediastinal mass that progresses to ALL
lymphoblastic lymphoma
like CLL with a focal mass
small lymphocytic lymphoma
20% mature T cell lymphoma?
diffuse large cell lymphoma
immature T cell lymphoma
lymphoblastic lymphoma
increased neutrophils and metamyelocytes?
CML
what bridges GP IIb/IIIa?
fibrinogen
bind IgE to the membrane?
basophils
mast cells
produces arylsulfatase?
eosinophils
causes of eosinophilis?
neoplastic
asthma
allergic process
collagen vascular disease
parasites
where are B cells found in the spleen?
white pulp
dendritic cells express MHCII and ____________ on the surface
Fc receptor
what is serum?
plasma--clotting factors
what is factor V Leiden mutation?
resistance to protein C
what are fibrin split products?
result from plasmin action on fibrin
what activates the complement cascade?
plasminogen
what does bradykinin do?
vasodilation
vascular permeability
pain
what causes both PT and PTT prolongation?
common pathway deficiency
severe hepatic disease
DIC
what causes target cells?
HbC
Asplenia
Liver disease
Thalassemia
what is HbC?
causes target cells
a different beta chain mutation than sickle cell
milder disease than HbS
what is increased serum LDH in indication of?
RBC hemolysis
differential for microcytic, hypochromic?
iron deficiency
thalassemia
lead poisoning
sideroblastic anemia
differential for macrocytic anemia?
megaloblastic anemia
drugs that block DNA synthesis (sulfa drugs, AZT)
causes of aplastic anemia?
NSAIDS
benzene
chloramphenicol
fatty infiltration of the bone marrow occurs in...
aplastic anemia
viral agents that can cause aplastic anemis?
B19
EBV
HIV
what confers malaria resistance?
HbS
G6PD deficiency
absence of Duffy blood antigens
what is increased in the urine for PNH?
hemosiderin
examples of intravascular hemolysis?
PNH
microangiopathic anemia
what kinds of anemias are associated with lupus?
warm agglutinin
microangiopathic
most common cause of DIC?
obstretric complications
what causes schistocytes, increased LDH and neurologic symptoms?
TTP
Disorders of the platelet GP recepors?
ITP (antibodies to IIb/IIIa)
Glanzmann's thrombasthenia (decreased IIb/IIIa)
Bernard-Soulier (decreased Ib)
petechiae and purpura indicate abnormality of what?
platelets
hemarthrosis and easy bruising indcate what?
clotting factor abnormality
Hemophilia A is factor ______
Hemiophilia B is factor _____
8
9
how is HUS different from TTP?
no neurologic abnormalities
most common type of Hodgkin's lymphoma?
nodular sclerosing
most common non-Hodkin's lymphoma?
follicular lymphoma
what lymphoma is associated with EBV?
Burkitt's lymphoma
what gene moves next to the heavy chain Ig gene?
t(8:14) Burkitt's
African form of Burkitt's presents with__________
sporadic form presents with ____________
jaw lesion....pelvis or abdomen
ALL and a mediastinal mass?
lymphoblastic lymphoma (immature T cells), children)
Pautrier microabscesses are associated with..
mycosis fungoides
leukemia characterized by splenomegaly?
CML
low LAP?
CML
anemia characterized by lymphadenopathy and hepatosplenomegaly?
CLL
leukemia assoicated with Down's syndrome?
ALL
responsive to all-trans retinoic acid?
M3 type AML
what characterizes Waldenstrom's macroglobulinemia?
plasmacytoid lymphocytes
what does GPIa do?
mediate platelet binding to collagen
what does GPIb do?
bind to vWF