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16 Cards in this Set
- Front
- Back
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Binds ergosterol and forms membrane pores (2)
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Amphotericin B
Nystatin |
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Inhibits ergosterol synthesis
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Fluconazoles, "-azoles"
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Inhibits DNA syn by conversation to fluorouracil, which competes with uracil
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flucytosin
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inhibits cell wall syn
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caspofungin
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inhibits squalene epoxidase
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terbinafine
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interferes with MT function; disrupts mitosis
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griseofulvin.
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Clinical use of Ampho B
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Systemic mycoses and OI
Intrathecally for fungal meningitis |
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fever/chills, hypotension, nephrotox, arrhythmias
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Amphotericin B
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use for nystatin
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oral candidiasis;
topical for diaper rash or vaginal candiasis |
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use for -azoles
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systemic mycoses
Fluconazole - cryptococcal meningitis in AIDS and candidal infections Ketoconazole - Coccidioides, Histoplasma, Blastomyces, Candida; hypercortisolism |
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gynecomastia, liver dysfunction, fever, chills
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-azoles
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systemic fungal infections like Candida and cryptoccus; major SE is bone marrow suppression
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flucytosine
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used for invasive aspergillosis
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caspofulgin
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used to treat dermatophytoses, especially onchyomycosis
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terbinafine
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used for oral tx of supf infections; inhibits growth of dermatophytes like tinea, ringworm
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griseofulvin
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teratogenic, carcinogenic, confusion, H/A, inc warfarin metabolism
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griseofulvin
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