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24 Cards in this Set

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-afil
Erectile dysfunction, ex Sildenafil. MOA: inhibits cGMP-specific phosphodiesterase. NO binds to guanylate cyclase receptors, causing smooth muscle relaxation and vasodilation. Tox: "hot and sweaty," then headache, heartburn, and hypotension.
-ane
Inhalational general anesthetic, ex Halothane. Main tox: massive hepatic necrosis, malignant hypertension (tx dantrolene).
-azepam
Benzodiazepine, ex Diazepam
-azine
Phenothiazine (neuroleptic, antiemetic), ex Chlorpromazine. Haloperidol + -azines = typical antipsychotics.
-azole
Antifungal, ex Ketoconazole. MOA inhibits ergosterol synthesis.
-barbital
Barbiturate, ex Phenobarbital. MOA increases the duration of GABA-A Cl- channel opening.
-caine
Local anesthetic, ex Lidocaine. MOA Na+ channel blocker. Esters have one I, Amides have 2 I's (relevant for allergies).
-cillin
Penicillin, ex Methicillin. MOA: beta-lactam drug inhibits transpeptidase, interfering with cell wall synthesis.
-cycline
Antibiotic, protein synthesis inhibitor, ex Tetracycline. MOA: binds 30S ribosomal subunit, inhibiting bacterial protein synthesis. Bacteriostatic.
-etine
SSRI, ex Fluoxetine
-ipramine
TCA, ex Imipramine. MOA: NE/5-HT reuptake inhibitor. Tox: Tri-C's (Convusions, Coma, Cardiotoxicity [arrhythmogenic]) and anticholinergic effects.
-navir
Protease inhibitor, ex Saquinavir "navir tease a protease inhibitor".
-olol
Beta blocker, ex Propranolol
-operidol
Butyrophenone (neuroleptic), ex Haloperidol (typical antipsychotic).
-oxin
Cardiac glycoside (inotropic agent), ex Digoxin
-phylline
Methylxanthine (similar to caffeine), COPD/asthma, ex Theophylline. MOA: cAMP phosphodiesterase inhibitor -> bronchodilation.
-pril
ACE inhibitor, ex Captopril
-terol
beta-2 agonist, ex Albuterol
-tidine
H2 antagonist, ex Cimetidine
-triptan
5-HT1B/1D agonists (migraine), ex Sumatriptan
-triptyline
TCA, ex Amitriptyline
-tropin
Pituitary hormone, ex Somatotropin
-zolam
Benzodiazepine, ex Alprazolam
-zosin
Alpha-1 blocker, HTN, anxiety, PTSD, panic disorder, BPH, ex Prazosin