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19 Cards in this Set

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  • Back
What are the 4 basic tissue types?
Epithelium, Connective Tissue, Muscle, Nervous tissue
What is tissue?
Cells + Extracellular matrix
What comprises ground substance?
Carbohydrates, proteins, electrolytes, and water with a jelly-like consistency.
What are the functions of GS?
- Resists comprssion
- Permits diffusion of nutrients & waste
What fibers are found in GS?
- Collagen fibers - structure
- Elastic fibers - stretch
What are glycosaminoglycans (GAGs)?
- CARBOHYDRATE chains.
- Negatively charged to attract NA+, and H20
- Resists COMPRESSION
- Covalently linked to proteoglycans
- Usually SULFATED
What is the only non-sulfated GAG?
- Hyaluronic acid - LARGE
- Causes gel state
What are proteoglycans (PGs)?
- PROTEIN core covalently linked to GAGs
- Attach NONCOVALENTLY to HA: GEL STATE, limiting diffusion
- Bacteria secrete hyaluronidase to permit rapid spreading
What are glycoproteins (GPs)?
- Repsonsible for cells binding to ECM
- Bind to cell INTEGRINS, COLLAGEN fibers, and PGs to fasten everything
What is COLLAGEN?
- Main ECM protein; flex but strong
- Made from tropocollagen molecules (3 alpha chains in a triple helix)
How is collagen synthesized?
- Preprocollagen: alpha chains with ADDED propeptide sequences
- 3 of these form a helix together with frayed ends
- Transported out, then PROCOLLAGEN PEPTIDASE cleaves propeptides to form tropocollagen mlcls
- Tropocollagen spontaneously assemble
What is the function of propeptides?
- Prevents intracellular formation of collagen
What are elastic fibers?
- Provide elasticity
- Made of protein elastin
What is the BASEMENT MEMBRANE?
- Light microscopic term. Narrow acellular region b/w eptih and CT
What comprises the BASEMENT MEMBRANE?
- Basal lamina --> produced by epith. cells
- Reticular lamina --> produced by CT cells
What is the BASAL LAMINA?
Lamina lucida + lamina densa
What is the LAMINA LUCIDA
Made of GP laminin --> attaches lamina densa to epithelium, INTEGRINS
What is the LAMINA DENSA?
Type IV COLLAGEN and PG
What is fibronectin?
GP in lamina densa that binds to reticular lamina