Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
1 Cards in this Set
- Front
- Back
|
Explain Sickle Cell Amenia
|
Mutation in humans, are sometimes found in the gene, which creates haemoglobin for red blood cells. This gives the different shape to the haemoglobin molecule. In this disease, during translation on chromosome 11 one base is substituted for another so that the codon GAG in the normal sense strand gives glu.ac (glutamic acid) and is substituted in the mutated sense strand becoming GTG giving val (valine.).
*Symptoms = weakness, fatigue, and shortness of breath. Because oxygen cannot be carried as efficiently by the irregular blood cells, the haemoglobin tends to crystallize within the red blood cells, causing them to be flexible. The affected red blood cells can get stuck in the capillaries so blood flow can be slowed or blocked. Mostly found in populations originating from West Africa or from the Mediterranean. People affected by sickle cell have a risk of passing the mutated gene to their offspring. |
