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75 Cards in this Set

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What does the ASPCA stand for?
American Society for the prevention of Cruelty to Animals
What does the AALAS stand for?
American Association for Lab Animal Science
What does the ILAR stand for?
Institute of Labratory Animal Research
What does the AAALAC stand for?
American Association for Accredidation of Labratory Animal Care
What does the AWA stand for?
Animal Welfare Act
Wat is the ASPCA do?
Promote humane prinicples and prevent cruelty to animals
Wat is the AALAS do?
Deals with production, care and study of Lab Animals
Wat is the ILAR do?
Make scientific data available to the scientific community so research is not repeated
Wat is the AAALAC do?
Promotes voluntary accredidation for humane tx of animals in research science
Wat is the AWA do?
Make unannounced visits to verify regulations are being carried out
What is an Animal "Model"
An animal chosen for research because of its similarities to the species that the research is being applied to
What is the criteria for selecting an animal model?
1)Similar characteristics
2)Size
3)Productivity
4)Longevity
What are the three main genetic categories used in biomedical research
1)Outbred Stock
2)Inbred Strains
3)FI Hybrids
1)What is Outbred Stock?
2)Is is strong or weak?
1) Produced in large colonies
Mating very random
Litters very unrelated
2) Strong
1)What is Inbred Stock?
2)Is is strong or weak?
1)Brother/Sister
Usually 20+ generations
Very homogeneous (similar)
Used to select specific trait or characteristics

2) Weak
1)What is FI Hybrids Stock?
2)Is is strong or weak?
1)result of 2 different inbred strains
2)Offsprings stronger than parents
What are the Ecologic Animal Types in research?
Axenic
Gnotobiotic (note-o-biotics)
Specific Pathogen-Free
Conventional
What is the microbial purity of Axenic animals?
Sterile
Free of all detectable microflora

(Most expensive - housing must be sterile at ALL times)
What is the microbial purity of Gnotobiotic animals?
Known type/s of microflora
What is the microbial purity of Specific Pathogen-Free Animals?
"SPF's" free of specific pathogens

(Most commonly used)
What is the microbial purity of Conventional animals?
Undefined microflora

(Collected from anywhere)
What are the housing factors for lab animals?
1) Temp control - 64-79f
2) Humidty control - 30-70%
3) Light Control - 12-14 hr cycle
4) Air control - 10-15 changes per day
There are 4
There IS regulations on this one!!!
What is the average weight of a rat?
300-400 grams
What is the average weight of a mouse?
25-40 grams
What is the average lifespan of a rat?
2 1/2 - 3 years
What is the average lifespan of a mouse?
1 1/2 - 3 years
What is the average puberty age of a rat?
6-8 weeks
What is the average puberty age of a mouse?
6-8 weeks
What is the average gestation period of a rat?
3 weeks
What is the average gestation period of a mouse?
19-21 days
What are is the scientific name for a rat?
Rattus Norvegicus
What are is the scientific name for a mouse?
Mus Musculus
Why are mice most commonly used in research?
1) Short life span
2) Short gestation
3) Large Litters
4) Inexpensive
5) Easy to maintain
There are 5 of them listed
What are mice used for?
1) Toxicity
2) Food
3) Pets
There are 3 of them on this one
What are rats used for?
1) Research
2) Pets
3) Food
There are 3 of them listed
What is important to know about the teeth of mice and rats?
They are open rooted
What does open rooted mean?
They continue to grow
Something is needed to grind them down or they need to be cut
How should you house mice?
1)Small groups
2)Seperate males & females
3)Bedding of wood chips
4)Hiding Spots
There are 4
How should you house rats?
1)Large cage
2)Small spacing between bars
There are 2
Rats:
What do they eat?
How much do they eat?
How much do they drink?
Lab blocks
Eat: Approx 20 grams/day
Drink: Approx 1-2 tsp/day
Mice:
What do they eat?
How much do they eat?
How much do they drink?
Lab blocks
Eat: 3-5 grams/day
Drink: Approx 5 mls/day (1tsp)
What is the behavior pattern of Mice?
Males = Territorial
Coprophagic
Nocturnal
Great nest bilders
Infrequently bite
Quite
What is the behavior pattern of Rats?
Usually quite
Usually friendly
Develop personalities
Trainable
Nocturnal (more than mice)
Seldom bite
Males: Rarely fight
Great escape artists
What are the identification methods of Mice & Rats?
1)Ear notching
2)Ear tagging
3)Microchip
4)Fur dying
5)Ink tail markings
What is the Whitten effect?
Females housed together
Male introduced
Estrus cycle will be syncronized
What is the Bruce effect?
Female mouse will abort if a strange male is introduced within 4 days of breeding
Does the Whitten effect occur in Mice, Rats, or Both?
Both
Does the Bruce effect occur in Mice, Rats, or Both?
Mice
How do you sex a mouse or rat?
Males: longer distance between anus and urogenital opening
You may see the testicles.
Why can it be hard to see testicles on a male?
They have open ingunial canals that they testicles can retract into
What does MRM stand for?
Murine Respiratory Mycoplasmosis
What is MRM?
Murine Respiratory Mycoplasmosis
Cronic disease
Caused by Bacteria - Mycolplasma Pulmonis
What are the signs of MRM?
Murine Respiratory Mycoplasmosis
Dyspnea
Rattling
sneezing
snuffy sounds
Later:
Weight loss
Head tilt
Pneumonia
Occ. increase of Red tears
What is Sendai irus
Causes pheumonia
May become susesptible to secondary infections
1)What is Obesity?
2)Who is more prone to it?
3)Why?
1)Overweight
2)Pet Rats
3)Too many treats
Poor diet
What are two Ocular conditions?
Periocular Porphyrin Staining
Retinal Atrophy
Periocular Porphyrin Staining
1)What is it caused by?
2)What happens?
1)Non-specific
Stress
Disease
2)Red tears secreted from Harderian Gland
Retinal Atrophy
1)What is it?
2)What is it caused by?
3)Sign?
4)Who is most prone to it?
1)Retinal detachment
2)Exaberated by lighting intesity
3)Head tilt
4)Older albino rats
What type of tumors do Rats usually have?
Benign
Where do female rats usually get tumors?
Mammary Tumors
Urinary Bladder Worms:
1)What is the scientific name?
2)Do they matter?
3)What do they look like?
1)Trichosomoides Crassicauda
2)No - just a finding
3)Chains of dark brown eggs
Ring Tail:
1)What is it?
2)What causes it?
3)Sign?
1)One or more constrictions of the tail
2)Low humidity (should be kept at greater than 50%
3)Constriction becomes necrotic and falls off after swelling
Malocclusion:
1)What is it?
2)What is a sign?
1)Overgrowth of incisors
2)Anexeria
Rat Bite Fever:
1)What is it?
2)What does it cause?
1)Bacterial infection
(Strep)
2)Septasemia & arthritis in people
Hantavirus:
1)Who is the primary host?
2)Host signs?
3)How is it shed?
4)Causes?
1)Wild rodents
2)No clinical signs
3)urine
Saliva
Feces
4)Hemoragic fever with Renal symptoms
Bite Wounds:
1)Cause?
2)Area it affects?
1)fighting of dominant males
2)Genital & tail
Barbering:
1)What is it?
2)What occurs?
1)Fur Chewing
2)Dominant male/females do to other housemates
External Parasites:
1)What are they?
2)What are the signs?
1)Lice & Mites
2)Itching
Hair loss
Self mutilation
Tyzzer's Disease:
1)What is it caused by?
2)What are the symptoms
3)Who does it affect?
1)Bacteria: Clostridium piliforme
2)Diarrhea
Dehydration
Hunched back
3)Rodents & other species
EPIM:
1)What does it stand for?
2)What is it?
3)Who does it affect?
4)What are the symptoms?
1)Epozotic Diarrhea in Mice
2)Rotavirus
3)Mice less than 2 wks old
4)Soft yellow stool
Dried feces around rectum
Stunted growth
What are the 6 ways to collect blood from rats?
Retroorbital sinus
Jugular Vein
Cephalic Vein
Tail vessel
Toe nial clip
Cardiac puncture
What are the 4 ways to collect blood from mice?
Retroorbital sinus
Tail vessels
Toe nail clip
Cardiac puncture
What are 5 ways to give meds?
SQ - Scruff or abdomen
IM - Quadriceps
IV - Lateral tail vein (mouse)
Jugular (Rat)
IP - Intaperitoneal
PO - Mouth
What are ways to euthanize mice & rats?
Carbon dioxide
Barbiturate overdose
Cervical dislocation (mice only)
Decapitation
Ether
Exsanguinate
How do you restrain a mouse?
Hold upright
Extend head & neck
Keep nose, head & neck aligned
Do not allow rodent to tip back