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13 Cards in this Set
- Front
- Back
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Increased temperature |
sox 9 expression increased, offspring are male |
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Decreased Temperature |
aromatase express and female offspring produced. |
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aromatase |
converts androgens into estrogens |
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haplodiploidy |
unfertilized eggs develop into uniparental haploid males, and fertilized eggs that can give biparental diploid females. |
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SRY |
expressed in somatic cells of indifferent gonad immediately before and during testis differentiation |
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SF-1 |
works with Sox9 to up regulate AMH/AMF expression in sertoli cells, activation expression of gene for testosterone synthesis in Leydig cells. |
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sox9 |
can replace SRY but SRY cannot form testes if sox9 absent. |
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Fgf9 |
necessary for leydig cells to proliferate |
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Bata catenin |
actively blocks sox9 |
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disheveled |
increases active bata-catenin |
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Dax 1 |
x-linked gene, expressed initially in genital ridge male and female, then only in xx, antagonizes function of sry and Sox9 |
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3 beta hydroxysteroid dehydrogenase deficiency |
xy infants have female or ambiguous appearing external genitalia, testes but low testosterone and elevated estrogen levels, infertiel |
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21 hydroxylase dficiency |
adrenal glands produce excess androgens, salt wasting, simple viriliziong and non-classic type, lose large amounts of Na+ in urine |
