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88 Cards in this Set
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Nonspecific lines o defense from pathogens that include barriers, protective cells and chemicals
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Innate immunity
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specific lines of defense involving cells of the immune system that target specific markers on pathogens
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Adaptive Immunity
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Skins is composed of two layers:
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Epidermis
and dermis |
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Dermis:
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lies under epidermis and contains hair follicles, glands and nerve endings
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epidermis
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Tightly packed cells
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Epidermis contains ____
cells |
Langerhans cells or epidermic dendritic cells that phagocytize pathogens nonspecifically
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Dermis has:
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Collegen to make skin pliable and tough to prevent cuts and contains sweat which contains sals
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Lysozomes
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Destroy cell wall of bacteria
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___ glands secrete sebum
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Sebaceous
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Mucous membranes are composed of
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epithelium (outer layer of cells) and connective tissue (provides blood)
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_____ cells produce mucus which traps pathogens and propelled out of body by ciliated columnar cells
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Goblet Cells
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Another name for antimicrobial peptides
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Defensins
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Cystic Fibrosis kills ____
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Columnar Cells
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The normal flora can change Ph and compete for nutrients against possible pathogenic organisms
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Microbial Antagonism
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Axenic
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Microbe Free
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Sweat Glands give us
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Salt
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Ferrin is latin for
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Iron
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White Blood cells that defend body against invaders
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Leukocytes
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secrete tears which contain lysozyme to destroy and wash away bacteria
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Lacrimal Apparatus
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The Body's Second Line of Defense is
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Cells of the Blood
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____ is made up of mostly water and contains electrolytes (ions) dissolved gases and nutrients and proteins (platelets)
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Plasma
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Serum is Plasma without what
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clotting factors
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Red blood cells are
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Erthrocytes
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White blood cells are
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leukocytes
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platelets
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Clot Blood
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Platelets are formed from
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megakaryocytes
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The body traps iron using ____
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transferrin
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Staphylococcus Aureus secretes what
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siderophores
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siderophores do what
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steal iron from body
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hemolysin bursts red blood cells and releases what
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their hemoglobin
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The body traps iron using
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transferrin
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Staphylococcus aureus secretes
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siderophores
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hemolysin does what
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bursts red blood cells
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2 types of leukocytes are
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granculocytes and agranulocytes
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granulocytes have large granules and includes
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neutrophils, eosinophils, and basophils
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basophils release
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inflammatory chemicals
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easinophils attack
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parasitic worms and cause allergic reactions
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agranulocytes include
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lymphocytes and monocytes
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monocytes are
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immature macrophages
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_____ macrophage wander thoughout the body
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wandering macrophage
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____ macrophage
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are in the lungs
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_____
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are in the central nervous system
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_____ cellls
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are in the liver
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_____ cells
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are found in the epidermis
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MAC
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membrane attach Complex
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What involves the use of pseudopodia to crawl towards pathogens
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chemotaxis
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phagocytes attach to pathogens by binding to glycoproteins
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adherence
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phagocytes are attracted to sides of infection by
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chemokines
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The coating of organisms which complement proteins for easier phagocytis
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opsonization
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After adherence, the pseudopodia envelope the organism and internalize it as a vessible called a
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phagosome
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lysosomes fuse with the phagosome forming a
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phagolysomes and they digest it
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the remnants are exocytosed or expelled
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elimination
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Serum proteins which acts as opsonins and chemokines triggering inflammation and fever
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complement system
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lymphocites are nonspecific leukocytes that secrete toxins on virally infected cells and tumors
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natural killer cells
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pathyway - complement is activated when they attach to antibodies attached to the surface of pathogens
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classical
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_____ pathway begins with cleavage of the C3 Complement protein which leads to the cleaving of other complement proteins leading to a cascading effect
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Alternative
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protein molecules released by host cells to nonspecifically inhibit the spread of viral infections
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interferons
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three classes of interferons
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alpha, beta and gamma
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___ Inflammation develops quickly and ends quickly
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acute
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___ inflammation developes slowly and lasts a long time
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chronic
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____ is the sticking of phagocytes to walls of blood vessels before diapedesis
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margination
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____ and leukotrienes cause vessels to leak fluid casing edema
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prostaglandins
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increased temps are triggered by
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pyrogens
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a pyrogen released by phagocytes that have phagocytized bacteria causes hypothalamus to increase thermostat setting
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interleukin-1
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Study of the body's immunity cells and chemicals
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immunologists
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three dimensional shapes of regions that the immute system recognizes as foreign
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epitopes
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____ antigens are outside of cell
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exogenous
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___ antigen are inside cell
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endogenous
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____ self antigen found in body's normal cell
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autoantigens
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Molecules that trigger a specific immune response
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antigen
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considered the third line defense is a smart system with memory capabilities
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adaptive immunity
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composed of lymphatic vessesls, cells, tissues, organs
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lymphatic system
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form a one way system conductin lymph, a colorless, watery substance much like plasma
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lymphatic vessels
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The smallest leukocytes (white blood cells)
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lymphocytes
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lymphatic organs include
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spleen, tonsils, mucosa-associated lymphatic tissue (MALT)
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B Lymphocytes originate in
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the red marrow of bone and mature there as well
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B Cells have surface antibodies and are found primarily in the spleen, nodes and MALT called
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plasma cells when actively fighting exogenous antigens
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another name for antibodies
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immunoglobulin and are soluble antigen binding proteins secreted by B Cells
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This is a part of what immune response
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Humoral
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ABS means
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Antigen Binding Sites
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particular antigenic determinant
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epitope
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A toxin or block bacterial and viral attachment to cells by binding to a critical portion so it can no longer be virulent
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ADCC
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a way of enhancing phagocytosis by covering antigen with antibody
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opsonization
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some antibodies are able to catalyze the production of hydrogen peroxide
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Oxidation
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with multiple binding sites, antibodies can attach to more than one microbe and bind several tgether hindering virulence
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agglutination
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____ consititutes 12% of serum antibody and comes as a monomer that circulates in blood
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IGA
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Secretory Iga found in secretions like tears and milk
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Dimmer
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3rd most common AB in initial states of an immune response
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IgM
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