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EXAM 4 PHYSIO: RENAL 5
EXAM 4 PHYSIO: RENAL 5
Principal cells secrete K in response to:
1. inc plasma K
2. inc Na load to cortical collecting duct (CCD)
Effects of aldosterone:
1. stimulates LUMINAL Na channels
2. stimulates BASOLATERAL Na/K ATPase
3. stimulates LUMINAL K channels

NOTE:
K is sacrificed to retain Na.
What causes the release of aldosterone?
1. inc plasma K
2. dec plasma vol (A II stimulates aldosterone secretion)
Excretion of K =
Filtration - Reabsorption + Secretion.
Excreted Calcium =
Filtered - Reabsorbed

NOTE: 98% of filtered Ca is reabsorbed.
Excretion of Phosphate =
Filtered - reabsorbed
Effects of PTH on PO4 reabsorption?
Inhibits PO4 reabsorption

Increased PTH level--> inc Ca reab--> dec PO4 reab.

Decreased PTH level--> dec Ca reab --> inc PO4 reab

NOTE:
Plasma PO4 does not affect PTH secretion from PTH gland.