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14 Cards in this Set
- Front
- Back
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*Endometritis*
Acute (inflammation of uterine lining) -Limited to ...-delivery or ... -Due to retained products of conception or instrumentation -Micro: Must see ... plus infiltration and destruction of glandular epithelium, as ... are common in cycling endometrium |
post
miscarriage microabscesses neutrophils |
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*Endometriosis*
-Endometrial glands ... the uterus -Found in ~7% of women of reproductive age -Sites: ovaries, uterine ligaments, fallopian tubes, rectovaginal septum, pelvic peritoneum, intestinal wall, appendix, vagina, bladder, umbilicus, surgical scars -... found in lymph nodes, lung, pleura -Endometrium undergoes ... bleeding -Causes scarring, pain, sterility (30% of pts) |
outside
Rarely cyclic |
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*... *
-AKA “Fibroid” -Benign smooth muscle tumor of ... -Most common tumor of female genital tract *Present in ~75% of women at autopsy *... common in African-Americans -Stimulated by ..., may regress after menopause and enlarge during pregnancy -Menorrhagia, metrorrhagia, urinary frequency, pelvic pain, or asymptomatic |
Leiomyoma
myometrium More estrogen |
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*Leiomyoma*
-Gross: ..., firm, round, white bulging mass, often multiple -Locations: submucosal, intramural, subserosal -Micro: fascicular pattern of smooth muscle bundles separated by well ... connective tissue |
well-circumscribed
vascularized |
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*... *
-Most common malignant tumor of female genital tract -Peak age: 55-65 (not before 40) -Frequently arises in endometrial ... -Risk factors: obesity, diabetes, nulliparity, endometrial hyperplasia, prolonged ... replacement, tamoxifen, ... producing tumors, polycystic ovarian disease -Symptoms: asymptomatic, leukorrhea, irregular bleeding |
Endometrial Cancer
hyperplasia estrogen estrogen |
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*Endometrial Cancer*
Prognosis: depends on ... 5 year survival for patients treated by stage: - 1 - 95%, 2 - 85%, 3-65%, 4-20% Gross: lush, polypoid endometrium with yellow ... areas Micro: most are ... with back to back glands and stromal invasion, low grade lesions have minimal atypia and high grade lesions have more prominent atypia |
stage
necrotic adenocarcinomas |
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*... *
-Tumor with differentiation along all three germ cell layers (ectoderm, endoderm, mesoderm) -Most are ... -Usually cystic -Often with skin inside (“... cyst”) -Sebaceous material, hair, teeth, bone, cartilage, thyroid tissue, bronchial tissue -Malignant variants have ... tissues |
Teratoma
benign dermoid immature |
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*... *
-Teratoma composed predominantly of mature thyroid tissue -May be functional --> ... -May develop cancer (typically ... carcinoma) |
Struma Ovarii
hyperthyroidism papillary |
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look at slide 48 in lecture 16
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ok
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*... *
-Malignant germ cell tumor -Young patients, most are under age 30 -Ovarian counterpart of testicular seminoma -Gross: solid, nodular, may be bulky -Micro: nests of tumor cells with ... cytoplasm and ... defined borders separated by fibrous stroma with ... lymphocytes -TX: Surgery and radiation therapy -Good prognosis: overall survival > 80% |
Dysgerminoma
clear well T |
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*Granulosa-Theca Tumors*
-Composed of a mixture of granulosa and theca cells or may appear composed entirely of ... cells -Majority are ... -Functional-> produce ... -Tumor marker: ... -SX: ... puberty in children, metrorrhagia, ( may have endometrial hyperplasia/carcinoma) -Gross: white or yellow mass -Micro: small, bland, cuboidal to polygonal cells in various patterns, including ... bodies (small follicle-like structures filled with acidophilic material) |
granulosa
benign estrogen inhibin precocious Call-Exner |
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*... *
-Commonly produce androgens -Results in defeminization/masculinization -Feminine characteristics return after surgery -... prognosis -Gross: solid gray to golden brown mass -Micro: Composed of poorly formed cords, nests, and tubules of tumor cells. Tumor cells have ... nuclei, a moderate amount of cytoplasm (... cells), and occasional mitosis. Interspersed between these are nests of polygonal cells with round nuclei and abundant granular cytoplasm (... cells). |
Sertoli-Leydig Cell Tumors
Good hyperchromatic Sertoli Leydig |
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*... *
-23,000 new cases / 15,000 deaths in 2007 -#1 cause of death among the tumors of the female genital tract -Peak age: ... -Most are ... |
Ovarian Cancer
50 cystadenocarcinomas |
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*Ovarian Cancer*
Often diagnosed at ... stage -Tumor often seeds peritoneal cavity Tumor marker: ... (not a good screening test. Often used for following patients) Symptoms: -feeling of fullness or bloating -pelvic or back pain Risk factors: -nulliparity -family history (BRCA gene mutation) -NOT using ...! |
advanced
CA-125 oral contraceptives |
