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17 Cards in this Set
- Front
- Back
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Progenitorsofgerm cells-primordialgerm cells- arise oneof two ways
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1) determined by autonomous cytoplasmic determinantsfrom the egg known as germ plasm-invertebrates, fish & frogs
2) specifiedbyinductive interactions betweencells-mammals |
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embryo |
epiblast-only 2 cell layers thick |
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Primordial germ cells are specified trough inductive interactions |
when the embryo begins gastrulation, and the primitive streak appears. |
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PGCs |
not morphologically distinct in early development |
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Diploid |
not gender specific |
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Germ cells induced by |
Bone Morphogenic Proteins |
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BMP4 and DMP8b |
secreted by extraembryonic ectoderm inducing Blimp 1 expression in the PGC precursor cells |
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PGCs cells express......in response to BMPs |
stella |
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Proximal posterior epiblast cells respond to signals from the extraembryonic cells |
inducing expression of Fragillis in the epiblast cells |
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fragillis |
competent to become PGCs cell |
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fibronectin |
extracellular matrix protein |
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Beta 1 integrin |
PGCs express receptor |
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Stem cell factor |
secretedby cells alongthe route of migration andthe PGCs express a receptor Kit |
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SDF1 |
secreted by genital ridge cells and PGCshave receptor CXCR4 and follow the gradient |
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Bipotentialgonads |
ariseas thickenings of intermediate mesoderm adjacent to the developing kidney –this is the genital ridge |
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Paramesonephric orMüllerian ducts |
becomethe major structures of the female tract |
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Wolffian oror mesonephric duct |
becomesthe male tract |
