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13 Cards in this Set
- Front
- Back
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Neural crest |
derive from ectoderm, transient population of pluripotent cells originating at the "crest" or dorsal side of the neural tube during neurulation |
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Neural crest development |
1.Neuralcrest is specified inthe dorsal lip of the neural tube. 2.Neuralcrest migrates fromthe dorsal neural tube. 3.Migrationcan be segmental andis regulated by expression of factors that repel cells, such as Eph/ephrins. 4.Neuralcrest can give rise to a number of different types ofdifferentiated cells. |
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Neural crest is specified by.... |
Wnt and then BMP signaling |
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EMT |
epithelial neural tube cells undergo and detach from dorsal neural tube. |
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ventral pathway |
cells travel ventrally through the anterior sclerotome |
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dorsolateral pathway |
cells travel between the epidermis and dermis |
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eph/ephrin expression |
somite segments are formed with anterior posterior regions. |
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neural crest migration |
avoids ephrins in the posterior (caudal) sclerotome |
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melanocytescranial + trunk dorsolateral neural crest generate |
melanocytes |
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melanocytes |
generate pigmentation |
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pharyngeal arches |
4 bilateral pairs of endodermally-lined outpocketings |
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pharyngeal grooves |
pharyngeal arches are separated by ectodermally covered inpocketings. |
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FGF8-MAPK |
promote cranial neural crest development. |
