Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
20 Cards in this Set
- Front
- Back
|
somitogenesis |
repeated segmentation process |
|
|
somites |
-formed rostral- caudal order, with head somites first, neck, then thoracic, lumbar and finally sacral and coccygeal somites |
|
|
Presomitic Mesoderm (PSM) |
somites segment from |
|
|
Mesenchymal to epithelial transition (MET) |
epithelialization |
|
|
Modulating presomitic mesoderm production in tailbund region regulates |
somitogenesis and axis extension |
|
|
tbx6 |
necessary for Presomitic Mesoderm identity and repressing neural tube fates |
|
|
Mesogenin1 (Msgn1) |
regulates Tbx6 |
|
|
Unique temporally colinear pattern of ......at each segmental level specify vertebral identity. |
Hox gene expression |
|
|
Decision Zone |
determination front -FGF8 and RA gradients induce differentiation of presomitic mesoderm at segmental boundaries. |
|
|
FGF8 |
promotes Msgn1/Tbx6 expression and PSM formation |
|
|
Mesodermal Posterior (mesp) |
•a transcription factor transientlyexpressed during somitogenesis. •Initiates MET via activation of repulsive Ephsignaling and cytoskeletal rearrangements |
|
|
DeltaISH
|
suggestsimportant role for Notch signaling in somitogenesis. •Mostrecent somite is position 1 (most caudal) to IV (more rostral) Somiteprecursors (somitomeres)numbered in reverse •-I =rostral somitomere to-IV more caudal somitomere •Studiesof delta expression following somitomere reversals suggests preciselocation of differentiationfront atsomitomere -IV |
|
|
Somitesegmentation requires cyclical Notch signaling |
•Segmentation requiresrhythmic/periodic/cyclic/oscillating expression of Notch negativefeedback regulators •Periodic expression not due to cellmovement but genes turning on and off in different regions over time |
|
|
Wavefront Model |
1.FGF8gradient specifies determination front (“wavefront”) and competence to respond toNotch. |
|
|
The Clock model |
1.CyclicalNotch regulators determine timing (clock) by specifying somite boundaries. |
|
|
Spondylocostal dysostosis |
a group of conditions characterizedby abnormal development or fusion of bones in the spine and ribs. |
|
|
somites compartmentalize |
intothe sclerotome anddermamyotome after formation |
|
|
sclerotome |
become cartilage |
|
|
dermamyotome |
become dermis and muscle |
|
|
Tendons |
develop from syndetome |
