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243 Cards in this Set

  • Front
  • Back

Who developed Infection Control and epidemiology ?

John Snow

Who advocated handwashing to prevent puerperal sepsis?

Ignaz Semmelweis

What is the smallest unit of measure?

Nanometer

Who developed the technique of vaccination to prevent small pox?

Edward Jenner

Who disproved spontaneous generation of microbes?

Louis Pasteur

Who was involved in Simple staining, Development of a method to prove the cause of an infectious disease and Techniques for isolating microbes in the laboratory

Robert Koch

The microbial production of alcohol from sugar is?

Fermentation

Microorganisms characterized by the absence of a nucleus?

Prokaryotes

The microbes commonly known as _________ are single celled eukaryotes that possess no cell wall and are generally motile

Protozoa

They are eukaryotes, have a cell wall and Yeasts are unicellular. Theses are characteristics of?

Fungi

They are acellular, not composed of cells, They are obligatory parasites, They are smaller than prokaryotic cells. Theses are characteristics of?

Viruses

The application of living organisms to restore a polluted environment is called?

Bioremediation

The cell of a _________ are composed of peptidoglycan;_________ have cell walls composed of something other than peptidoglycan

Bacteria; archea

What tells you how many protons are in an atom?

Atomic number

When an atom loses an electron it becomes ___________?

A Cation

pH is the measurement of the amount of hydrogen (H+) ions in a solution. As the concentration of ions increases, pH goes __________?

Down

Smallest unit of an element?

An atom

Matter composed of only one kind of atom?

Element

Matter composed of two or more different kinds of atoms chemically combined?

Compound

Two or more atoms chemically combined?

Molecule

Organic compounds are those that contain carbon and hydrogen. Which is an organic compound?


1. Methane CH4


2. Carbon dioxide CO2


3. Water H20

Methane CH4

Match the building blocks to the Organic molecules



1. Carbohydrates A. Amino acids


2. Protein. B. Glycerol and


3. Lipids fatty acids


4. Nucleic acid. C. Nucleotides


D. Mono-


saccharides

1. Carbohydrates- monosaccharides


2. Protein- amino acids


3. Lipid- glycerol and fatty acids


4. Nucleic acid- nucleotides

External structural components of ______________ are Cell membrane, Cell wall and Lipopolysaccharide (LPS) layer in gram-negative bacteria

Bacteria

The short, numerous appendages used by some bacterial cells for adhering to surfaces are called?

Fimbriae

The transfer of genes during bacterial conjugation involves a rigid tubular appendages are called?

Sex pili

__________ is composed primarily of phospholipids and proteins (phospholipid bilayer) as described by the fluid mosaic model.

The cell membrane

Is Gram- positive cells: Lipid A, Lipopolysaccharide mismatched?



True or false

True

Crenation, the shriveling of cells due to loss of water, occurs when cells are paved in what type of solution?

Hypertonic

Is glycocalyx: holds genetic information mismatched?



True or false

True

Dormant, resistant cells formed during unfavorable conditions

Endospores

Who was the first person in history to view protozoa and bacteria called animalcules?

Antoni Van Leeuwenhoek

A microbiologist is observing an amoeba at 450x using a compound light microscope. If the ocular lens of the microscope has a magnification of 10x, what us the magnification of the objective being used?

45x

The ability to distinguish between two adjacent objects is called

Resolution

What is the purpose of staining samples?

To increase the contrast and visibility of the specimen

Who introduced binomial nomenclature as a way to classify and identify similar organisms?

Linnaeus

In the binomial system of nomenclature, which term is always written in lowercase letters?

Species

According to the binomial nomenclature system is this correct?



Streptococcus pyogenes (all italized)

Yes

The round shape of bacteria is called?

Cocci/ Coccus

After gram staining the pink round bacteria it would be classified as?

Gram negative

A gram-positive bacteria is simple stained using the dye safrinin red. What color will it appear when observed in the microscope?

Red/pink

What has a thick layer of peptidoglycan layer, no outer layer, gram Stain purple.

Gram positive bacteria

If you have a sugar and water solution, sugar would be?

The solute

What process is Diffusion, Osmosis and Facilated diffusion part of?

passive process

What is the most suitable microscope for viewing a virus?

Transmission electron

What are the functions of the cell membrane in a bacteria

- Energy storage


- Harvest light energy for photosynthesis


- Selectively permeable to most substances

I am a gram-negative bacillus that tolerates oxygen. I ferment lactose, used citric acid as my sole carbon source and PRODUCE ACETOIN but not hydrogen sulfide gas. Who am i?

Enterobacter

The molecule that an enzyme Acts upon is known as its?

Substrate

Is this matched correctly? Catabolic reaction : requires ATP



True or false

False

They may require coenzymes, They are catalytic protein and They are insensitive to pH are all features of?

Enzymes

The principle source of readily usable Energy for cells is?

ATP

What Is the metabolic pathway of



glucose + oxygen--> carbon dioxide + water + energy

Aerobic cellular Respiration

What Is the metabolic pathway of



Pyruvate --> organic acids

Fermentation

What Is the metabolic pathway of



10 step pathway 1 glucose --> 2 pyruvate

Glycolysis

What Is the metabolic pathway of



Acetyl-coa --> CO2 + Electron carriers

Kreb's cycle

When a molecule that is not the normal substrate for an enzyme binds to the active site of the enzyme you have?

Competitive inhibition of the enzyme

Denaturation is most often a problem with?

Proteins

Beta-oxidation is a method of catabolizing this molecule

Glycerol

What Is the major function of fermentation?

It regenerates NAD+ for glycolysis

Beta-oxidation located in the Mitochondria in bacteria?



True or false

False

Some bacteria are able to reduce nitrite (NO3-) to nitrite (NO2-). when these bacteria are present in the human bladder, nitrite accumulation results and may be the indicator for a UTI. When nitrite is reduced it ________ electrons.

Gain electrons



Reduction Is Gain


Oxidation Is Loss

A cell that uses an organic carbon source and obtains energy from chemicals would be called a

Chemoheterotroph

A halophile might grow beat in this environment

A jar of Greek olives

Match the temperatures they go best at



1. Mesophile. A. 50° to 60° C


2. Thermophile. B. 20° to 40 ° C


3. Psychrophile. C. 5° to 15° C


4. Acidphile. D. pH 0.0 to 4.5

1. Mesophile. B. 20° to 40° C


2. Thermophile. A. 50° to 60 ° C


3. Psychrophile. C. 5° to 15° C


4. Acidphile. D. pH 0.0 to 4.5

What cannot grow in the presence of oxygen?

Obligate anaerobe

What can grow in the presence or absence of oxygen?

Facultative anaerobe

What is oxygen dependent- must have oxygen to grow

Aerobe

What grows in an atmosphere of lower oxygen and often higher CO2

Microaerophile

Serial dilutions are used to

Slow down the growth of microbes

During the process of tooth decay, multiple species of bacteria adhere to the solid surface of the teeth In sequential layers. The complex arrangement of bacteria forms a highly resistant microbial community known as a?

Biofilm

Medium 1 is?

Both selective and differential

The sequence of DNA that specifies a protein is?

A gene

The sum of all the genetic information in a cell is?

The genome

A small circular piece of DNA that replicates independently of the chromosome in bacteria is?

Plasmid

The visible/physical appearance of a cell or organism

Phenotype

Small molecules of DNA that replicate independently that may be found in prokaryotic genomes are called __________. These pieces of DNA are not essential to growth, metabolism, or production, but may carry virulence factors or fertility factors .

Plasmids

Part of mRNA sequence is 5'-CGUCAAAAG -3'. Assuming that this part of the sequence encodes three amino acids, the sequence of amino acids could be?

Arginine- Glutamine- Lysine

All organism in or an object have been inactivated or destroyed

Sterile

A chemical used to reduce the number of bacteria to acceptable public health standards

Sanitizer

A chemical used on inanimate objects to reduce the number of pathogenic microorganisms

Disinfectant

A chemical agent which can be used on living tissue

Antiseptic

The figure shows the results of an experiment with an antimicrobial chemical applied at 2 different temperatures, 20°C and 45°C. Which like represents the death rate at the LOWER temperature, 20°C?

Line B

3 structures of DNA

- The two strands of DNA molecule are antiparallel to each other


- DNA contains the sugar deoxyribose


- The two strand of DNA molecules are held together by hydrogen bonds

In the genetic code, each amino acid in a polypeptide is coded for by codon or

Three nucleotides in mRNA

The semi-conservative process of which one DNA polynucleotides strand is built upon an existing single stranded DNA template is call (DNA to DNA)?

Replication

Transcription produces

RNA molecules

The sites of protein synthesis in the bacterial cell occurs in/on

Ribosomes

These 3 are used in the translation process of protein synthesis

- mRNA


- rRNA


- tRNA


What is the strand of DNA that would base pair with the sequence TACAGGCCTTT during DNA replication?

TACAGGCCTTT=


ATGTCCGGAAA

The ames test is used to test whether or not a chemical is?

Mutagenic

What chemical category does betaine and other iodophores belong in?

Halogens

What chemical category does cepacol and other quats belong in?

Surfactants/ detergents

What chemical category does hydrogen peroxide belong in?

Oxidizing agents

What chemical category does thimerosal and mercurochrome belong in?

Heavy metals

Paul Ehrlich foresaw that the key to successful chemotherapy against microbes is _________ that is, the ability of a antimicrobial drug to be more toxic to a pathogen than to the pathogen's host

Selective toxicity

Antimicrobials like tetracycline that are effective against gram-negative organisms, gram-positive organisms, chlamydia and Rickettsias are termed?

Broad spectrum drugs

Why are some drugs that inhibit protein synthesis in bacteria also harmful to humans?

Eukaryotic mitochondria have 70S ribosomes

A patient develops a C. Diff colon infection as a result of antibiotic therapy for a respiratory infection. Explain why?

The antibiotics have disrupted the normal microbiota of the intestines

Antibiotics, such as cephapexin, which contains beta lactam rings act against bacteria by

Interfering with cell wall synthesis

Can bacteria become resistant to antimicrobial drugs by planning new mutations to deactivate the drugs?

No. (Producing enzymes deactivate drugs)

All viruses follow the same general life cycle



True or false

True

Viruses lack?

- Cytosol


- Organelles


- Ribosomes



They have nucleic acid

The caps of a virus is made out of _________ while the envelope is made out of __________

Protein; phospholipid

Scientists have determined that prion diseases are not caused by a type of slow virus because prions _____________

Contain no nucleic acid

In the early 1900s, F Peyton Rous discovered the cancer-causing virus RSV. This virus had a genome that contained

An oncogene

What is the order of a typical viral replication cycle?

Adsorption, entry or penetration, uncoating, synthesis, assembly and maturation, exit

A virus that is specific for a bacterial host is called a?

Phage

Is this mismatched? Cancer: invasive neoplastic cells

Yes it is

West Nile virus encephalitis is caused by WNV. Wild birds, notably house sparrows are natural host to WNV. the virus is normally carried into humans by the bites of mosquitos. The mosquito passes the virus from birds to humans. From this description, WN encephalitis is a ___________ and the mosquito is the ___________

Zoonosis; vector

E. Coli are normally present in large numbers in the healthy intesties; however their infection in the urinary tract usually results in disease. An organism that is not normally pathogenic but may cause disease when present in the wrong location is known as

Opportunistic

Normal microflora may be found in

- Nasal mucosae


- Stomach


- Vagina

The disease known as tetanus or lock jaw is caused by the baterium clostridium tetani. An individual contracts the disease when bacterial endospores present in the environment are inoculated into a wound; the bacteria are not spread from person to person. This type of disease is

Non-communicable and infectious

Which of the following is a sign of disease?



- Nausea


- Malaise


- Muscle pain


- Rash

Rash

What term applies to the presence of microbes in or on the body?

Contamination

A general term for a continual source of infection is?

Reservoir

A fungal diseases can be transmitted through the air (more than 1 meter) via fungal spores. This type of disease transmission is called?

Vehicle transmission

Ebola fever, which develops rapidly but last only a short time is best described as an?

Acute disease

A common portal of entry for microorganisms is

Mucous membrane

A short time of generalized, mild symptoms preceding illness is the?

Prodromal period

Some viruses can become latent and dormant in the host cells. The host may show no viral activity for years. This can be caused by?

Permanent incorporation of the provirus into the host DNA

One aspect to consider when prescribing an antibiotic is the efficacy of the drug. One test to determine the effectiveness of the drug is?

Minimum inhibitory concentration test

Viruses have an extracellular state and an intracellular state. What comprised the intracellular state of a virus?

Nucleic acid

Replication of DNA virus occurs in the _________ of a host cell; while replication of a RNA virus occurs in the _________ of a host cell

Nucleus; cytoplasm

A virus that is specific for a plant is called?

Viroid

What do you call chemicals that act against any disease?

Chemotherapeutic agents

Inexpensive, Easily administered And Chemically stable for long term storage describe what?

ideal antimicrobial agent

What is a disadvantage associated with the used of broad-spectrum antibiotics?

They kill normal microbiota

What is the minimum inhibitory concentration (MIC)?

the smallest amount of drug that will inhibit the growth and reproduction of a pathogen

The genomes of viruses are composed of which nucleic acid?

DNA or RNA

The phospholipid portion of enveloped viruses come from?

Host cell membranes

What is the name of the proteinaceous subunit that makes up the viral capsid?

Capsomere

All prion diseases result in what symptoms

Fatal neurological degeneration

____________ is a symbiotic relationship in which one organism benefits and the other organism neither benefits nor is harmed

Commensalism

Microorganisms that are able to colonize the skin or mucosal surfaces for a limited period of time are called?

Transient microbiota

What is an example of a parenteral route of infection?

Stepping on a nail

What type of disease develops and lasts for a long period of time?

Chronic

What term best describes the total number of disease cases in an area during a given period of time?

Prevalence

What term best describes an epidemic that occurs simultaneously on more than one by continent?

Pandemic

What can happen if an antimicrobial agent affects both pathogen and normal microbiota?

A secondary infection can develop

Most antifungal agents target what cellular structure?

Cytoplasmic membrane

What route of administration results in the lowest drug concentrations in the body?

Local

Some antimicrobials can permanently affect a developing fetus



True or false

True

You are speaking with a patient who has been prescribed amoxicillin for a middle ear infection. This statement would indicate a good understanding of the instructions

"I will take the full course of the antibiotics and return for a re-check"

When an organism evade the body's external defenses, multiplies and becomes established in the body is known as

An infection

What contributes to protecting the eyes from microbial invasion?

Tears contain lysozyne ans salt and mechanical flush particles from the eyes

The presence of normal microbiota that protects the body by competing with pathogens in a variety of ways to prevent pathogen's from invading body refers to

Microbial antagonism

Which cell becomes a macrophage when leaving the blood stream?

Monocyte

What is the process in which cell squeeze through the lining of capillaries to attack invading microbes?

Diapedesis

The first line of defense include both cellular and humoral immunity?



True or false

False


Skin and mucous membranes, Complement and Inflammation are all part of?


Non specific immunity

Does the alkali pH of the skin's surface inhibit growth of bacteria?

No, high salt inhibits growth

These 3 blood cell types are part of the body's second line of defense

- Neurophils


- Granulocytes


- Leukocytes

What does cells of the immune system that ingest pathogens refer to ?

Phagocytosis

Serum proteins involved in nonspecific defense are part of

The complement system

All of the cells or formed elements in the blood originate in?

The spleen

Molecules that damage cells and result in cell lysis are called?

Toll like receptors

A substance formed by virally infected cells which protects uninfected cells from the virus is

Lysozyme

The redness and heat of an inflamed area are due to

Vasoconstriction

A differential blood count shows that your patient has a high eosinophil count that amounts to 8% of his total white blood cells. This patient had spent the last three years as an antrpologist living among people in a remote part of Africa. What do you expect from his blood profile?

The patient has eosinophilia usually causes by an infection with a parasitic worm

Phagocytic white blood cells include?

Neutrophils

The condition that is caused by exogenous and endogenous pyrogens is?

Fever

Immunity following recovery from mumps is an example of ?

Naturally acquired active immunity

Substances recognized by the immune system as foreign which stimulate an immune response are?

Antigens

Proteins produced by the body in response to foreign substances entering the body are known as

Antibodies

A ring of lymphoid tissue that appears as a swelling of the mucous membrane in the oral cavity is called?

Tonsil

Small organs associated with lymphatic vessels are terms

Lymph nodes

___________ supplies immunity by Opsonization of target antigens, Neutralizing toxins and viruses and Activating complement and inflammation

Antibodies

The blood cell responsible for producing antibodies is the?

B-lymphocyte

A sick child comes to the urge care clinic with an upper respiratory infection, either influenza or RSV. antibody tests are ordered to determine the source of illness. The results are: anti-influenza antibodies are primarily IgM and anti-RSV antibodies are all IgA and IgG. What is the most appropriate interpretation?

The child has a current influenza infection and has had previous exposure to RSV

The immune system's ability to recognize self-antigens and not Acts against normal body cells I known as ?

Self tolerance

The amount of antibody titer produced during the primary response is

Less than that of the secondary response

The active agents of humoral immunity includes?

B cells and antibodies

The thymus, Lymph nodes and Hematopoietic stem cells are components of the what system?

The lymphatic system

The antigens that a T cell recognizes in order to determine "self" are termed

Major histocompatibility (MHC) antigens

A man had chicken pox when he was an infant. Now thirty years later his infant daughter contracted chicken pox, and he is able to care for her without fear of contracting the disease. what adaptive immunity is most important for this protection against the disease?

Memory

Pentacel is a vaccine against diptheria, tetanus, pertussis, polis, and the haemophilus influenzae. This type of vaccine is a

Combination vaccine

What type of cell is most heavily depleted during an HIV infection?

Helper T cells

A type of vaccine which may cause a very mild infection but no serious disease under normal conditions is an

Attenuated vaccine

Passive immunotherapy is used when

Protection against a recent infection is needed immediately

This is typically not part of an ART cocktail for treating AIDS

Corticosteroids

This is not a primary immunodeficiency disease

AIDS

What behaviors increase the risk of HIV infections?

- Anal intercourse


- IV drug use


- sexual promiscuity

The enzyme used by HIV to create a DNA copy of its RNA genome is

Reverse transcriptase

This is not a criterion for diagnosing AIDS in a patient who was HIV positive?

A rise in the population of CD4 cells

A life threatening allergic reaction to an injected vaccine is ?

Anaphylactic shock

The most important vasodilator acting in acute inflammation is?

Histamine

HIV can be spread in all of the following bodily fluids

- Blood


- Semen


- Breast milk

A small percentage of HIV-Infected individuals are long term nonprogessors due to

Mutated coreceptors for the virus or mutated virus/virion

Describe attributes of adaptive immunity

Specificity, clonality, self tolerance, memory and inducibility

What type of vaccine will contain adjuvant to increase the effectiveness of the vaccine?

Inactivated vaccine

The CDC recommends that adults obtains at least one booster against the caustic agent whooping cough (pertussis dtap)



True or false

True

Polio vaccines should be boosted every ten years though out adult life



True or false

False

Cell-mediated immunity would be employed in the neutralization of exotoxin?



True or false

False

A person with AIDS would be expected to have a severely depleted population of

- CD4 cells


- helper T cells


- Th cells

What is a complication that may result from a streptococcus pyogenes skin infection?

Erysipelas

Impetigo can be cause by

Staphylococcus aureus

Necrotizing fasciitis is caused by

Streptococcus pyogenes

Spreading black necrosis, swelling, pain, and froth or bubbles ar characteristics of

Gas gangrene

Anthrax derives it's name from what aspects of the disease?

The appearance of eschars on the skin

Common skin warts are the result of infection with?

Papillomavirus

Localized swelling of a scratch accompanied by fever, malaise and swollen lymph nodes may result from infection with?

Bartonella henselae (cat scratch)

Shingles or herpes zoster is a reactivation of the virus that cases ?

Chicken pox

What disease can cause birth defects?

Rubella

A small puncture would on a woman's arm has become swollen, hot to the touch, and intensely painful. There is tissue necrosis but it is not gassy and under the microscope gram-positive cocci chains are present. What microbes is likely responsible?

Streptococcus pyogenes

Under some circumstances __________ is beneficial, but under other conditions the bacteria becomes over abundant leading to inflammation of hair follicles

Propionbacterium acnes

The presence of koplik's spots is sufficient in diagnosis of?

Measles

Encephalitis is an infection of?

The brain

Newborn exposed to the gram-positive bacterium __________ during vaginal birth are at risk for developing neonatal meningitis

Streptococcus agalactiae

Contaminated food is the source of ___________, which causes meningitis in the elderly and susceptible persons

Listeria monicytogenes

The type of bacterial meningitis that becomes epidemic among young adults is caused by

Neisseria meningitidis

An intracellular parasite primarily transmitted as an STD is the agent __________ which may cause enough damage to result in blindness

Trachoma

The highly destructive form of Hansen's disease is the result of

Poor immune response to mycobacterium leprae

Viral meningitis is also called "aseptic meningitis because

It indicates no bacteria are involved

Poliovirus is most often transmitted via

Contaminated water

African sleeping sickness is fatal if not treated because the parasite

Evades destruction by the immune system by changing surface antigens

A child is brought to the hospital with a high fever, nausea, and vomiting and complaining of a headache. The CSF collected by spinal tap is cloudy and contains spherical cells which stain gram-negative. These signs and symptoms are consistent with

Bacterial meningitis probably due to streptococcus

One summer, bird watcher and zookeeper in a major city notice that more birds than usual are dying. At the same time reports of human encephalitis cases increase sharply. The CSF of human patients is clear. Similar enveloped RNA virus particles are detected in samples from.both birds and humans. What disease might be responsible for the outbreak?

Arbovirus

Nasal or ocular contact with water containing _________ may result in primary amebic meningoencephalitis

Both acanthomoeba and naegleria

The disorder __________ is a condition of systemic infections with streptococcus in which antigen-antibody complexes form in the blood and gets trapped in the kidneys

Glomerulonphritis

During the spring calving season, a ranch hand begins to run a fever and feel nauseous and achy. After he develops a headache and vomiting, he goes to the clinic. A microscopic exam of a urine sample reveals long thin microseconds which move very rapidly in a corkscrew pattern. The man contracted?

Leptospirosis

The majority of cases of staphylococcal toxic shock syndrome occur in

Menstruating women

The typical signs of primary syphilis is

A chancre at the site of infection

The presence of gram-negative diplococci in pus from an inflamed penis is diagnostic for infection by

Neisseria gonorrhoeae

Chancroid is caused by

haemophilus ducreyi

The yeast infections caused by __________ can become systemic in AIDS patients

Candidiasis

A patient complains of fever, pain on one side of the Body and fatigue. The clinician notes the patient's blood pressure is somewhat elevated. The patient reports experiencing some painful urination for a few days during the previous week tests on urine sample reveal the presence of motile gram-negative bacilli. What describes with scenario?

- Enteric bacteria


- UTI caused by fecal contamination of the urethra


- E. Coli

Folliculitis when it occurs at the base of the eyelid

Sty

Multiple furuncle grow together to produce these

Carbuncles

Infection of hair follicle, often called a pimple

Folliculitis

Spread of hair follicle infection into surrounding tissue

Furuncles

I am an obligately aerobic gram-negative bacillus, resistant to antibiotics frequently implicated in nosocomial infections of burn patients. I produce a noticeable green pigment and i have a distinctive aroma. What am i

Pseudomonas

A disease caused by a fungus is

A mycosis

Ringworm is caused by a

Fungus

Double vision, floppy paralysis

Botulism

Loss of cutaneous sensation

Hansen's disease/ leprosy

Spastic paralysis, clenched teeth

Tetanus

Premature abortion and fetal death, meningitis

Listeriosis

____________ is the vector responsible for transmitting rocky Mountain spotted fever B

Tick

____________ is the vector responsible for transmitting leishmaniasis

Sand fly

____________ is the vector responsible for transmitting rabies

Bat

____________ is the vector responsible for transmitting west Nile virus

Mosquito

Intact skin will not prevent entry of this disease

Scabies

The leading cause of nontraumatic blindness is

Chlamydia trachomatis

The characteristic between impetigo and erysipelas is

Impetigo mainly occurs in children and erysipelas occurs in the elderly