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26 Cards in this Set

  • Front
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lecture 5 – urology
ok
Hematuria:

> ... RBCs/HPF (seen in U/A) – unspun urine (should undergo evaluation)

confirm microscopic hematuria on ... w/ microscope exam
3
dipstick
Detection:

1. Dip Sticks – colorimetric assay

2. False ... for dipsticks
-Oxidizing agents (povidione, bacterial, peroxidases)
-Myoglobinuria

3. False ... dipsticks
-Reducing agents (Vitamin C)
-Urine pH <5.1
positive
negative
Voiding symptoms:
-Dysuria (burning w/ urination), frequency, urgency, nocturia

W/ burning and frequency,
-in older, think ...
-in younger, consider ... or medication
urinary or prostatic obstruction
STD
Physical exam:

HTN, edema, CVAT, trauma, meatal stenosis (caruncule, condyloma), pelvic exam (vaginal bleeding)

-edema – think ...
-CVAT (costovertebral angle tenderness) - ... etiology
-diabetes – think renal ... or parenchymal disease
renal failure
infectious
stenosis
Labs:

-U/A
-... – impt particularly for those bleeding quite heavily. check to see if they are anemic.
-renal function and chemistries
CBC
Color:

Bright Red – active bleeding (think ... or ...)
Brown – old (..., old clots)
tumor or stone
glomerular nephritis
Proteinuria:

Present
- suggest ... parenchymal disease
- 3+ or 4 + on dipstick > ... mg/dL

Absent – does not eliminate renal parenchymal disease but suggests ... cause or interstitial disease
renal
150
urologic
Casts:

RBC casts
-pathognomonic for ... bleeding
-crystalluria – suggests ... disease

WBC casts
-suggests ...
glomerular
stone
pyelonephritis
Red cell morphology – phase contrast microscopy (used for microscopic hematuria, not often used for gross hematuria):

dysmorphic cells suggest ... disease
normal cells suggest ... disease

slide 18
glomerular
urologic
Urologic evaluation:

... is the most sensitive way to diagnose urolithiasis (but do both w/ and w/o contrast)

renal ... is very helpful in differentiating between a cyst or solid.
CT scan w/o contrast
ultrasonography
look at slide 19-20
ok
It is impt to obtain a ... for a pt who presents w/ kidney stone disease
CT scan w/o contrast
start lecture 6 – urolithiasis
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Urolithiasis: SIGNS AND SYMPTOMS

Upper urinary tract calculi
— Renal colic is classically associated with ...-onset, severe flank ... over the affected side.
—Pain may radiate to the ipsilateral anterior lower abdominal quadrant, groin, or scrotum (labia in females).
—Patient unable to find comfortable position; pain not improved by lying still
—Associated nausea, vomiting common
— Microscopic or gross hematuria almost always present
—Fever or elevated white blood cell count if asso¬ciated ...
—May be asymptomatic if stone not causing ...
-if obstruction + infection, --> ...!
sudden
pain
infection
ob¬struction
emergency!
Lower urinary tract calculi:

—May be asymptomatic
—Sudden interruption of urinary ... as stone acutely obstructs bladder neck; may lead to moderate-to-severe pain when ...
— Microscopic or gross hematuria
stream
voiding
Causes/risk factors (upper urinary tract calculi):

-... stones most common
-... – radiolucent. won’t show up on X-ray. often shows up on CT scan
-... stones are infectious in etiology (often pseudomonas)

Get a serum calcium level and uric acid level – if high calcium and uric acid, suspect a ....
calcium oxalate
uric acid
struvite (magnesium ammonium phosphate)

parathyroid tumor
Upper urinary tract calculi cont:

-... stone formation may be due to dietary excess (high protein intake), gout, myetoproliferative disorders, chronic dehydration, Lesch-Nyhan syndrome, in¬gestion of uricosuric drugs (salicylates, thiazides), or idiopathic.
—... stones are associated with urinary tract infection with urease-splitting organisms (Proteus, Klebsiella, and others), leading to alkaline urine and magnesium ammonium phosphate crystallization.
—... stones are rare and associated with an inherited disorder of renal. tubular reabsorption of cystine.
Uric acid
Struvite
Cystine
Lower urinary tract calculi:

—... stones seen in patients with foreign material in bladder (proline mesh, chronic catheterization); inadequate bladder emptying as in neurogenic bladder or chronic bladder outlet obstruction (most often due to ...)
Bladder
benign prostatic hyperplasia
PHYSICAL EXAMINATION:

Fever present if associated infection
-Moderate, deep tenderness in flank common greater tenderness suggests possible ...

An abdominal mass suggests another cause pain besides urolithiasis.
-Elevated heart rate and blood pressure secondary to pain

Physical findings tend to generally be ... in terms of aiding w/ the diagnosis of kidney stones.
pyelonephritis
rare
LABORATORY TESTING

Urinalysis
- Microscopic hematuria unless stone has caused complete obstruction and no urine from affected , side; pyuria may be present to mild degree, if significant pyuria suggests concomitant ...
- ... may provide important information regarding the type of calculus present.

Leukocytosis may be present if ... infection

Elevated ... may be present if bilateral obstruction or stone in solitary kidney
urinary tract infection
Crystalluria
secondary
creatinine
What is often the first imaging study used in evaluating those suspect for kidney stone disease?
CT scan
GENERAL MEASURES:

Stones < ...-... mm likely to pass; stones > ... cm unlikely to pass spontaneously
-Take home message - The ... and ... of the stone is impt


Indications for intervention
—Fever and/or ...
—Intractable ...
—Unable to tolerate oral fluid and at risk for dehydration
—Progressive renal deterioration; obstruction of ... functioning kidney
4 to 5
1
size and location
infection
pain
solitary
MEDICAL stone tx:

-Patients with evidence of active ... should be treated with broad-spectrum an¬tibiotics.
-Hydration and adequate pain control
-Drinking excessive amounts of fluids ... increase the likelihood of stone passage.
-Patients with a likelihood of spontaneously passing a stone (<4—5 mm in size) may be sent home with analgesics; should be instructed to re¬turn if pain worsens, or severe vomiting or fever
-Controversy exists regarding maximum period of observation of partially obstructing stone without development of significant irreversible renal dys¬function; generally should intervene if stone has not passed within ... to ... weeks
-drugs that may be beneficial in passing a stone: alpha adrenergic blockers, medrol dose pack, NSAIDS
urinary tract in¬fection
does not
4 to 6
Surgical stone tx:

Patients with active UTI/sepsis: obstructed kidney drained by placement of ureteral ... or percutaneous nephrostomy tube
-Calculi in kidney: ... with or without stent placement
-Ureteral calculi: ESWL or ... stone removal; the approach depends on size and location of stone, availability of ESWL, and patient and physician preference.
-Stent placement in anticipation of ureteral dilation and subsequent spontaneous stone passage is an option for patients with smaller ureteral calculi.
stent
ESWL (extracortical shock wave lithotrypsy)
ureteroscopic
PREVENTION:

... is the single most important measure to avoid recurrent stone formation.
Increased fluid intake (produce ~2 quarts of urine/day)