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25 Cards in this Set
- Front
- Back
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if erythrocytes decrease, they’re turning over more rapidly --> ...
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anemia
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if erythrocytes increase --> ...
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polycythemia
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normal bicarbonate concentration in human plasma is ...-... mEq/liter
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24-30
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Transferrin is the protein that ... is usually bound to
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iron
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Ceruloplasmin is the protein that ... is usually bound to
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copper
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... = density of a material (liquid) relative to water
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specific gravity
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Lipoproteins:
from ... dense to ... dense Chylomicrons – located in ... VLDL, IDL, LDL – located in ... HDL – located in ... and ... |
least
most intestine liver liver and intestine |
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what is the most negatively charged protein in the bloodstream?
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Albumin
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anions migrate towards the ... (the ... charged end)
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anode
positively |
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serum + ... = plasma
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fibrinogen
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serum ... clot
plasma ... clot |
will not
will |
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what is the function of Albumin? (2)
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-Osmotic regulation (maintenance of oncotic pressure)
-transport of multiple things (fatty acid anions, bilirubin, etc.) |
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What is the function of Thyroxine-binding protein (TBPa)
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Binding and transport of thyroxine
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What is the function of Ceruloplasmin?
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Copper transport
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what is the function of Transferrin?
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iron transport
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for most blood proteins, the T(1/2) is ca. ... days
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10
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Albumin:
...% of the total plasma protein -...% is present intravascularly -...% is located in the extracellular space *Responsible for oncotic pressure. Think volume. Liver produces 12-17 gms/day -...% of total hepatic protein synthesis -...% of the secreted protein |
60
40 60 25 50 |
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Bilirubin and Fatty acids competitively bind to ...
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albumin
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Toxicity: Billirubin ... - big issue in newborns
1. Billirubin inhibits ... and ... synthesis in brain. 2. Inhibits ... metabolism in brain. 3. Impairs protein synthesis in ... 4. Serum levels should not exceed ... mg/dL |
Encephalopathy
RNA and protein carbohydrate liver 20 |
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Billirubin Toxicity:
Prophylactic use of ... in newborns enhances Billirubin Encephalopathy ... drugs -contrast mediums will competitively bind to the Billirubin binding sites of Albumin |
sulfonamide
Cholangiographic |
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... pressure = fluid to intercellular spaces
... pressure = fluid attracted back into bloodstream by protein |
hydrostatic
oncotic |
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...
-generalized protein deficiency -edema present ... -decrease in calories across the board -edema absent |
Kwashiorkor
Marasmus |
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Ceruloplasmin:
1. Major carrier of ... 2. levels increase during pregnancy – estrogens react with steroid receptors to increase synthesis in ... 3. Levels ... during tissue injury and disorders producing inflammation |
copper
hepatocytes increase |
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... disease – a hereditary disturbance in copper metabolism in which biliary excretion of copper is impaired; this leads to decreased levels of Ceruloplasmin in the blood
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Wilson’s
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Iron metabolism:
Iron is absorbed from the diet, transported in the blood in ..., stored in ..., and used for the synthesis of cytochromes, iron-containing enzymes, hemoglobin and myoglobin. It is lost from the body with bleeding and sloughed off cells, sweat, urine and feces. ... is the protein in which excess iron is stored. Small amounts of ... enter the blood and can be used to measure the adequacy of iron stores. |
transferrin
ferritin Hemosiderin ferritin |
