Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
34 Cards in this Set
- Front
- Back
|
name 5 indirect acting sympathomimetics
|
amphetabmines, ephedrine (displace NT from its stores in nerve ending)
cocaine, tricyclic antidepressants (inhibit reuptake of NT) |
|
|
which sympathomimetics can cross BBB?
|
indirect: amphetamines for exampe to elevate mood and insomnia
|
|
|
activation of alpha 1 in eye does what?
|
dilation (mydriasis)
|
|
|
activation of beta2 in bronchioles does what?
|
bronchodilation
|
|
|
use of amphetamines in CNS?
|
treat ADHD, narcolepsy, suppress appetite
|
|
|
DOC for anaphylactic shock?
|
Epi b/c it acts on alpha R's to increase BP
|
|
|
DOC for actue asthmatic bronchospasm?
|
beta 2 agonists b/c bronchodilation
|
|
|
what do you use to decrease blood flwo?
|
alpha agonists: to reduce bleeding and congestion and to prolong local anesthesia
|
|
|
what type of drugs are used to suppress preterm labor?
|
ritodrine: beta2 agonists
|
|
|
all sympathomimetics may cuase?
|
arrhthmias and infarction
|
|
|
ending for alpha blockers?
|
-osin
|
|
|
how can your overcome noncompetive alpha blockers?
|
high amots of alpha agonists
|
|
|
what drug to you use to Tx pheochromocytomas?
|
phenoxybenzamine b/c noncompetivie, nonselevetive, irreversible alpha blocker
|
|
|
majore CV effects of alpha blockers?
|
decreased TPR
decreaed BP reflex tachycardia |
|
|
explain the Epi reversal
|
in presence of high concentrations of Epi, alpha blockers cause an actual reversal of BP response to the agonsit; the normal hypertenisve response (mediated by alpha R's) is converted to a hypotensive response (mediated by Beta 2 R's)
|
|
|
waht happens to the alpha agonist actions of Epi in the presence of alpha blocker?
|
b/c Epi cna't bind to alpha R's to cuase vasoconstrictors, it binds to beta2 R's to now cause vasodilation and a decrease in BP: in other words, the normal hypertenisve effects of alpha Rs is now a hypotensive B2 response
|
|
|
what is prazosin?
|
alpha blocker
useful in treating BPH and primary HTN |
|
|
how is prazosin useful in treating BPH?
|
relax muscles in the prostate, via vasodilation
|
|
|
what are phenyoxybenzamine and phentolamine?
|
alpha blockers
|
|
|
waht is pindolol?
|
partial beta agonst and is used extensivley as a beta antagonist
|
|
|
why do we use beta blockers to treat HTN?
|
b/c they lower BP b/c of their combined effects on the heart, RAA system, and CNS
|
|
|
effect of beta blockers on airway?
|
increse airway resistance..bronchospasm which is more pronounced in asthmatics
|
|
|
what type of drug do you give pts who had MI to decrease mortality?
|
beta blocker
|
|
|
topical Beta blockers are used for Tx of?
|
glaucoma
|
|
|
what do you not want to give someone iwth asthma?
|
beta blocker
|
|
|
waht does chronotropic effect mean?
|
increase rate (beta 1agonist on heart)
|
|
|
what does inotropic effect mean?
|
increas force (beta1 agonist on heart)
|
|
|
action of beta 2 agonist?
|
relaxation of vascuar smooth muscle
may invoke reflex increase in heart rate |
|
|
how can Beta blockers be used to treat glaucoma
|
they decrease the prodxn of aqueous humor
|
|
|
waht individual beta blocker is useful in treating glaucoma?
|
timolol
|
|
|
action of dobutamine?
|
synthetic catecholamine
selective effect on Beta 1 R's increase CO |
|
|
albuterol is what type of agonsit?
|
beta 2
vasodilator |
|
|
isoproterenol activates what R's?
|
beta R's
dilates bronchial smooth mm increases heart rate and contractility |
|
|
waht is phenylephrine
|
alpha agonist
vasocontrxn, increse TPR |
