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98 Cards in this Set

  • Front
  • Back
Botulinum
Anticholinergic
Binds SNARE-25 and inhibits exocytosis
Vesamicol
Anticholinergic
Destroys the vesicles for ACh
Hemicholinum
Anticholinergic
Choline reuptake inhibitor
Can't synthesize new ACh
Neostigmine
Cholinergic
Inhibits AChE
(give with atropine)
Physostigmine
Cholinergic
Inhibits AChE
(Give with atropine)
Latrotoxin
Cholinergic
Explosive release of ACh
Organophosphates
Cholinergic
Irreversibly bind AChE
Pilocarpine
Muscarinic agonist
Causes SLUDE
Bethanecol
Muscarinic agonist
Causes SLUDE
Atropine
Muscarinic antagonist
(Prevents SLUDE - give with cholinergic drugs)
Succinylcholine
Nicotinic agonist
Hexamethonium
Mecamylamine
Nicotinic antagonist
(Ganglionic)
Inhibit whichever system has tonic control:
Tachycardia
Hypotension
Dry mouth
Blurred near vision
Constipation
Curare
Nicotinic antagonist
(NMJ)
Reserpine
Antidopaminergic/Antiadrenergic
Inhibits monoamine transport
Guanethidine
Antiadrenergic
Inhibits NE release
Guanadrel
Antiadrenergic
Inhibits NE release
Ephedrine
Adrenergic/Dopaminergic
Increases release of NE and DA
Tyramine
Adrenergic
Increases release of NE and DA
Amphetamine
Adrenergic/Dopaminergic
Increases release of NE and DA
Cocaine
Adrenergic
Inhibits reuptake of NE and DA
Imiprin
Adrenergic
Inhibits reuptake of NE and DA
Tolcapone
Adrenergic
COMT inhibitor
Tranylcypromine
Adrenergic
MAOI
Selagine
Adrenergic
MAOI
Oxymetazoline
Non-selective alpha-agonist
Phenylephrine
alpha-1 agonist
Clonidine
alpha-2 agonist
Phenoxybenzamine
Non-selective alpha antagonist
Phentolamine
Non-selective alpha antagonist
Prazosin
Alpha-1 antagonist
alpha-methyl-tyrosine
Antiadrenergic
Blocks TH in catecholamine synthesis
Yohimbine
alpha-2 antagonist
Isoproterenol
Non-selective beta-agonist
Propanolol
Non-selective beta-antagonist
Beta-blocker
Decrease HR, CO and vasoconstriction of systemic vasculature
Dobutamine
Beta-1 agonist
Terbutaline
Beta-2 agonist
Acebutolol
Beta-1 antagonist
Atenolol
Beta-1 antagonist
Esmolol
Beta-1 antagonist
Metoprolol
Beta-1 antagonist
Betaxolol
Beta-2 antagonist
Apomorphine
Dopamine agonist
Bromocryptine
Dopamine agonist
Antipsychotics
Antidopaminergic
Kainate
Glutamate agonist
Neuroprotective agents
Glutamate antagonists
Barbiturates
GABA-A agonist
Benzodiazepines
GABA-A agonist
Bicculine
GABA-A antagonist
Picrotoxin
GABA-A antagonist
Baclofen
GABA-B agonist
Fluoxetine
Serotonergic
SSRI
Sertraline
Serotonergic
SSRI
Paroxetine
Serotonergic
SSRI
Fluvoxamine
Serotonergic
SSRI
Citalopram
Serotonergic
SSRI
Trazodone
Serotonergic
SSRI
Mirtazepine
Serotonergic
Blocks serotonin autoreceptors
Ketaserin
Antiserotonergic
Ondansetron
Antiserotonergic
Venlafaxine
SNRI
Duloxetine
SNRI
Milnacipran
SNRI
Lithium
Anti-manic
Blocks Ca dependent NE/DA release
Valproate
Anti-manic
Anti-convulsant
Inhibits Na channels
Carbamazepine
Oxcarbazepine
Anti-manic
Anti-convulsant
Inhibits Na channels
Olanzapine
Anti-manic
Anti-psychotic
Buproprion
Weak SNRI
Quetiapine
Anti-manic
Neuroleptic
Imotrigine
MANIA and DEPRESSION TREATMENT
Morphine
strong opiate
Heroine
strong opiate
Methadone
strong opiate
less addictive
Oxycodone
moderate opiate
Meperidine
moderate opiate
Codeine
weak opiate
Diphenoxylate
very weak opiate (diarrhea treatment)
Propoxyphene
very weak opiate (PO in hospitals)
Etorphine
VERY strong opiate
Nalorphine
partial agonist opiate
Pentazocine
partial agonist opiate
Naloxone
opiate antagonist
Naltrexone
opiate antagonist
(addiction treatment)
Imipramine (Desipramine)
TCA
Inhibits NE/5-HT reuptake
Amitryptilline (Nortryptilline)
TCA
Inhibits NE/5-HT reuptake
Chlorimpramine
TCA
Inhibits NE/DA reuptake
Doxepine
TCA
Inhibits NE/DA reuptake
Limbritol
TCA
Inhibits NE/DA reuptake
Travil + etrafron
TCA
Inhibits NE/DA reuptake
Secondary vs Tertiary amines for TCA activity
Teriary amines are degraded to secondary amines
Tertiary - inhibit NE and 5-HT reuptake
Secondary - inhibit NE reuptake
Isocarboxazide
Adrenergic/dopaminergic
MAOI
Tricyclic antidepressants
(Mechanism, Indications, Effects)
Mech: Block monoamine reuptake channels, particularly NE with secondary amines
Indications: Depression, insomnia, bulimia, migrane, anxiety/OCD, neuralgia
Effects: immediate: NE increase in synaptic cleft. long-term: decrease alpha-2 receptors, decrease postsynaptic beta receptors, increase in LC firing and NE production
Tricyclic antidepressant
(Side effects, pharmaco)
CV: arrhythmias, MI, hypotension, tachycardia
Decrease autonomic response: antimuscarinic effects, dry mouth, blurred vision
Sedation, weight gain
Pharm: metabolized to secondary amine, NE selective, metabolized in liver
SHIFT OF ED50 --> LD50
MAOI's
(Mechanism, Indications, Effects)
Bind MAO-A to inhibit breakdown of Epi, NE, DA, 5-HT
Indi:depression, hypersomnia, hyperphagia, panic attacks, post-traumatic, bulimia
Effects: Increased NE levels cause desensitization/downreg.
Then, long term alteration
MAOI's
(Side effects, pharmaco)
Sedation/excitation, parasymp inhibition, CNS overstimulation, Hypertensive crisis, liver/CNS toxicity, myoclonus, hypotension
Pharm: Serotonin syndrome, liver metabolism, tyramine overdose
SSRI's
(Mechanism, indications, effects)
Mech: serotonin specific reuptake inhibitor
Indi: depression
Effects: serotonin increase, downstream genetic changes for long-term effects
SSRI
(side effect and pharmacology)
Side effects: safer than other drugs, OD = CNS overstimulation/seizure, GI bleed, nausea, sexual dysfunction, weight gain, insomnia, decreased platelets
Pharm: protein bound, liver metabolized, taper off gradually
SLUDGE
Parasympathetic signs
(Specifically muscarinic)
Salivation
Lacrimation
Urination
Defication
GI upset
Emesis