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98 Cards in this Set
- Front
- Back
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Botulinum
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Anticholinergic
Binds SNARE-25 and inhibits exocytosis |
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Vesamicol
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Anticholinergic
Destroys the vesicles for ACh |
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Hemicholinum
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Anticholinergic
Choline reuptake inhibitor Can't synthesize new ACh |
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Neostigmine
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Cholinergic
Inhibits AChE (give with atropine) |
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Physostigmine
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Cholinergic
Inhibits AChE (Give with atropine) |
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Latrotoxin
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Cholinergic
Explosive release of ACh |
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Organophosphates
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Cholinergic
Irreversibly bind AChE |
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Pilocarpine
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Muscarinic agonist
Causes SLUDE |
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Bethanecol
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Muscarinic agonist
Causes SLUDE |
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Atropine
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Muscarinic antagonist
(Prevents SLUDE - give with cholinergic drugs) |
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Succinylcholine
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Nicotinic agonist
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Hexamethonium
Mecamylamine |
Nicotinic antagonist
(Ganglionic) Inhibit whichever system has tonic control: Tachycardia Hypotension Dry mouth Blurred near vision Constipation |
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Curare
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Nicotinic antagonist
(NMJ) |
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Reserpine
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Antidopaminergic/Antiadrenergic
Inhibits monoamine transport |
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Guanethidine
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Antiadrenergic
Inhibits NE release |
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Guanadrel
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Antiadrenergic
Inhibits NE release |
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Ephedrine
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Adrenergic/Dopaminergic
Increases release of NE and DA |
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Tyramine
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Adrenergic
Increases release of NE and DA |
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Amphetamine
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Adrenergic/Dopaminergic
Increases release of NE and DA |
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Cocaine
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Adrenergic
Inhibits reuptake of NE and DA |
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Imiprin
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Adrenergic
Inhibits reuptake of NE and DA |
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Tolcapone
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Adrenergic
COMT inhibitor |
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Tranylcypromine
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Adrenergic
MAOI |
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Selagine
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Adrenergic
MAOI |
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Oxymetazoline
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Non-selective alpha-agonist
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Phenylephrine
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alpha-1 agonist
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Clonidine
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alpha-2 agonist
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Phenoxybenzamine
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Non-selective alpha antagonist
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Phentolamine
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Non-selective alpha antagonist
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Prazosin
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Alpha-1 antagonist
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alpha-methyl-tyrosine
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Antiadrenergic
Blocks TH in catecholamine synthesis |
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Yohimbine
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alpha-2 antagonist
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Isoproterenol
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Non-selective beta-agonist
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Propanolol
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Non-selective beta-antagonist
Beta-blocker Decrease HR, CO and vasoconstriction of systemic vasculature |
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Dobutamine
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Beta-1 agonist
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Terbutaline
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Beta-2 agonist
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Acebutolol
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Beta-1 antagonist
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Atenolol
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Beta-1 antagonist
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Esmolol
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Beta-1 antagonist
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Metoprolol
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Beta-1 antagonist
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Betaxolol
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Beta-2 antagonist
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Apomorphine
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Dopamine agonist
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Bromocryptine
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Dopamine agonist
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Antipsychotics
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Antidopaminergic
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Kainate
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Glutamate agonist
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Neuroprotective agents
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Glutamate antagonists
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Barbiturates
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GABA-A agonist
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Benzodiazepines
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GABA-A agonist
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Bicculine
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GABA-A antagonist
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Picrotoxin
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GABA-A antagonist
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Baclofen
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GABA-B agonist
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Fluoxetine
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Serotonergic
SSRI |
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Sertraline
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Serotonergic
SSRI |
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Paroxetine
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Serotonergic
SSRI |
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Fluvoxamine
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Serotonergic
SSRI |
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Citalopram
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Serotonergic
SSRI |
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Trazodone
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Serotonergic
SSRI |
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Mirtazepine
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Serotonergic
Blocks serotonin autoreceptors |
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Ketaserin
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Antiserotonergic
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Ondansetron
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Antiserotonergic
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Venlafaxine
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SNRI
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Duloxetine
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SNRI
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Milnacipran
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SNRI
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Lithium
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Anti-manic
Blocks Ca dependent NE/DA release |
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Valproate
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Anti-manic
Anti-convulsant Inhibits Na channels |
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Carbamazepine
Oxcarbazepine |
Anti-manic
Anti-convulsant Inhibits Na channels |
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Olanzapine
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Anti-manic
Anti-psychotic |
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Buproprion
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Weak SNRI
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Quetiapine
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Anti-manic
Neuroleptic |
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Imotrigine
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MANIA and DEPRESSION TREATMENT
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Morphine
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strong opiate
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Heroine
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strong opiate
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Methadone
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strong opiate
less addictive |
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Oxycodone
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moderate opiate
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Meperidine
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moderate opiate
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Codeine
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weak opiate
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Diphenoxylate
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very weak opiate (diarrhea treatment)
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Propoxyphene
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very weak opiate (PO in hospitals)
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Etorphine
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VERY strong opiate
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Nalorphine
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partial agonist opiate
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Pentazocine
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partial agonist opiate
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Naloxone
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opiate antagonist
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Naltrexone
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opiate antagonist
(addiction treatment) |
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Imipramine (Desipramine)
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TCA
Inhibits NE/5-HT reuptake |
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Amitryptilline (Nortryptilline)
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TCA
Inhibits NE/5-HT reuptake |
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Chlorimpramine
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TCA
Inhibits NE/DA reuptake |
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Doxepine
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TCA
Inhibits NE/DA reuptake |
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Limbritol
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TCA
Inhibits NE/DA reuptake |
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Travil + etrafron
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TCA
Inhibits NE/DA reuptake |
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Secondary vs Tertiary amines for TCA activity
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Teriary amines are degraded to secondary amines
Tertiary - inhibit NE and 5-HT reuptake Secondary - inhibit NE reuptake |
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Isocarboxazide
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Adrenergic/dopaminergic
MAOI |
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Tricyclic antidepressants
(Mechanism, Indications, Effects) |
Mech: Block monoamine reuptake channels, particularly NE with secondary amines
Indications: Depression, insomnia, bulimia, migrane, anxiety/OCD, neuralgia Effects: immediate: NE increase in synaptic cleft. long-term: decrease alpha-2 receptors, decrease postsynaptic beta receptors, increase in LC firing and NE production |
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Tricyclic antidepressant
(Side effects, pharmaco) |
CV: arrhythmias, MI, hypotension, tachycardia
Decrease autonomic response: antimuscarinic effects, dry mouth, blurred vision Sedation, weight gain Pharm: metabolized to secondary amine, NE selective, metabolized in liver SHIFT OF ED50 --> LD50 |
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MAOI's
(Mechanism, Indications, Effects) |
Bind MAO-A to inhibit breakdown of Epi, NE, DA, 5-HT
Indi:depression, hypersomnia, hyperphagia, panic attacks, post-traumatic, bulimia Effects: Increased NE levels cause desensitization/downreg. Then, long term alteration |
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MAOI's
(Side effects, pharmaco) |
Sedation/excitation, parasymp inhibition, CNS overstimulation, Hypertensive crisis, liver/CNS toxicity, myoclonus, hypotension
Pharm: Serotonin syndrome, liver metabolism, tyramine overdose |
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SSRI's
(Mechanism, indications, effects) |
Mech: serotonin specific reuptake inhibitor
Indi: depression Effects: serotonin increase, downstream genetic changes for long-term effects |
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SSRI
(side effect and pharmacology) |
Side effects: safer than other drugs, OD = CNS overstimulation/seizure, GI bleed, nausea, sexual dysfunction, weight gain, insomnia, decreased platelets
Pharm: protein bound, liver metabolized, taper off gradually |
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SLUDGE
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Parasympathetic signs
(Specifically muscarinic) Salivation Lacrimation Urination Defication GI upset Emesis |
