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347 Cards in this Set

  • Front
  • Back

What is evolution?

-change that is heritable across generations


- it happens in populations not individually


Dobzhansky:

- Ukranian


- Biological species concept

What is microevolution and on what level does it occur?

- allele frequencies changing


- occurs on the population level

What is macroevolution and on what level does it occur?

- how species form


- occurs on the species level

What do all evolving species have (3)?

- populations


- variation


- hereditary similarity

What are the four elements of evolution by Natural Selection?

- competition


- variation


- heritability


- irrigation

What does RNA splicing do?

- creates multiple proteins from a single gene

What are the 3 types of noncoding regions?

- mobile genetic elements


- RNA genes


- Pseudogenes

Georges Louis Buffon (2):

- species arise as distinct entities


- diverse environments give rise to new varieties

Georges Cuvier:

- Extinction

James Hutton:

- The earth transformed gradually

William Smith:

- 1st geological map

Jean Baptiste Lamark (3):

- species evolve thru natural process


- species are constantly generated


- adaptation occurs thru inheritance of acquired characteristics

Ways we know whales are mammals (5):

- produce milk


- placental birth


- hair


- mammary glands


- 3 middle ear bones

What are synapamorphies?

- Similarities b/w mammals

What can be viewed as a series of bifurcations in a phylogenetic tree?

- Evolution


Thomas Malthus (2):

- essay on principle of populations 1798


- populations reproduce exponentially

What did Thomas Malthus say about the rate of reproduction?

- natural populations have a large capacity to reproduce and if left unchecked will reproduce at a rapid rate

What is the fate of duplicate genes (3)?

- retain original function and provide additional copy of locus


- accumulate point mutations and become functionless pseudogenes


- gain a new function thru mutation and selection

Neofunctionalization:

- gaining a new function thru mutation and selection

What is a point mutation?

- Base pair substitutions in DNA sequences

What causes a point mutation?

- chance errors during DNA synthesis or repair of damaged DNA

What is the outcome of a point mutation?

- creates new alleles

What is a chromosome inversion?

- flipping of chromosome segment, gene order altered on chromosome

What causes a chromosome inversion?

- breaks in DNA due to radiation

What is the outcome of a chromosome inversion?

- alleles on inversion side are "locked together" in a unit

What is gene duplication?

- duplication of a short stretch of DNA creating an additional copy of a gene

What causes gene duplication?

- unequal crossing over in meiosis

What is the outcome of gene duplication?

- extra gene is free to mutate and perhaps gain a new function

What is polyploidity?

- addition of a complete set of chromosomes

What causes polyploidity?

- errors in meiosis, (mitosis in plants)

What is the outcome of polyploidity?

- can create new species

Are germline mutations heritable?

YES!

What is the mutation rate in human males compared to females?

- on the order of 10x

How many fertilized eggs are abnormal? How many spontaneously terminate?

6% abnormal


5.5% terminate spontaneously

Sir Ronald A Fischer (2):

- father or modern synthesis


- spoke about mutational effects

What is the fuel for evolution by Natural selection?

- mutations of small effect

What is the mutation rate subject to?

- evolutionary modification

What are the majority of mutations?

- deleterious

What 3 mechanisms generate variation?

- recombination


- independent assortment


- meiosis

Polymorphisms:

- can produce differences in phenotype


What are quantitative trains influenced by and what do they generate?

- influenced by multiple genes


- generate a normal distribution


What type of individual carries 2 alleles at every locus?

- a diploid individual

Population Genetics:

- study of distribution of alleles in population


- causes allele frequency changes

Mechanisms of evolution:

- forces that change allele frequencies


Where is sampling error highest?

- small populations


What does genetic drift reduce?

- heterozygosity

Monozygotic:

- identical twins


Dizygotic:

- fraternal twins

T.H. Morgan:

- founder of drosophila genetics

R. Goldschmidt:

- theory of "hopeful monsters"

Ne or Na (2):

- effective population size


- total # of active breeding adults in a population

Sewall Wright (2):

- effective population size


- F statistics

Is natural selection the same as evolution?

NO!

What is natural selection:

- variation in average reproductive success among different phenotypes

When can Natural Selection cause evolution?

- When differences among phenotypes is partly genetic

What is an example of heterozygote advantage?

- sickle cell heterozygote has advantage in areas with maleria

What is fitness?

- reproductive success of an individual with a particular phenotype

What are the 3 components of fitness?

- fecundity


- mating success


- survival to reproductive age

Relative fitness:

- fitness of genotype compared to others

Alleles that lower fitness have what type of selection?

- negative selection

Alleles that increase fitness have what type of selection?

- positive selection

When does selection occur?

- When genotypes differ in fitness

What does population size influence (2):

- power of drift and selection

What does balancing selection maintain?

- multiple alleles in populations

What is migration (gene flow):

- movement of individuals or gametes among populations

What is the result of migration (gene flow):

- decreases variation between population

What are direct measures to measure migration?

- mark and recapture

What are indirect measures to measure migration?

- molecular market

Continent Island Model (2):

- 1 way movement from large continent to small island


- movement random among groups of small populations

Stepping stone model:

- each population receives migrants from neighboring populations

What is the effect of alleles from an island on those of a continent?

- negligable

What is the affect of alleles from a continent to those of an island?

- continent represents a large fraction of island alleles

Hi:

- heterozygosity of an individual

Hs:

- heterozygosity of a subpopulation


Ht:

- heterozygosity in a total population

What is inbreeding depression?

- As inbreeding coefficient (F) increases, fitness decreases

Rare deleterious alleles are likely to combine...:

- heterozygotes

What does inbreeding decrease?

- % of homozygous loci identical for descent

What is our example of the extraterrestrial origin of life?

- Panspermia

Darwins idea of evolution required what?

- an old earth

Who disputed Darwins idea of an old earth?

- Lord Kelvin

What did Lord Kelvin propose?

- earth is no more than 20 myo based on the temperature of rocks


- he was WRONG


How old is the earth?

- approx 4.6 BYO

Charles Doolittle Walcott:

- Burgess Shale 1090

How old is the Burgess Shale:

505 MYO

Earliest signs of life (2):


- dates to 3.7 BYA


- carbon turned into rocks


What constitutes most of earths biodiversity?

- microbes

Origin of multicellularity (2):

- evolved independently in different linneages


- extant organisms provide clues about the origin of multicellularity

When do the earliest algae fossils date to?

- 1.6 BYA

Eukaryotic Multicellular life ( 2 algaes):

Red Algae: 1.2 BYA


Green Algae: 750 MYA

Protozoic Era (2):

- 2.5 MYA -> 543 MYA


- prokaryotic and eukaryotic algae

How old are the oldest fossils of multicellular animals?

- 640 MYO

Edicaran Fauna (3):

- best known precambian animals


- soft boddied (no skeleton)


- crept/stood on sea floor


Paleozoic Era:

- Cambrian Period: 543-500 MYA

What is the most amazing record of the cambrian period?

Burgess Shale

When did the cambrian explosion start?

530 MYA

How did the cambrian period end?

Mass extinction


During the cambrian period, what did diversification do?

promoted increasing oxygen levels

What does earliest animal life resemble?

sponges

Oldest terrestrial plant fossils:

475 MYO - mosses


When did fungi appear?

400 MYA

First terrestrial vertebrates?

- tetrapods


- 370 MYA

What did mammals evolve from?

Synapsids


When did mammals diversity?

- after dinosaurs went extinct


- 65 MYA

Phenetics:

- method used to classify based on phenotype


- molecular and morphological


What does homoplasy result from?

- Convergent evolution


What was tictaalic (2)?

- transitional fossil b/w fish and tetrapods


- had wrists!!

When did feathers evolve?

- before flight

The transition to unique human traits involved (3):

- bipedality


- larger brain size


- canine teeth

The transition to bipedality involved (3):

- weight bearing stance


- position of the forearm magnum


- short, stiff toes

What evolved first - bipedality or large brain?

bipedality

What was the mamalian inner ear made of?

modified parts of the jaw

What is exaptation?

FEATHERS

What is the primary function of mRNA?

serve as primary transcripts during transcription

What does tRNA do?

transports amino acids and ribosomes


Whos writing influenced Darwin and Wallace's theories of natural selection?

Thomas Malthus

Who were the 3 founders of the modern synthesis?

- JBS Haldane


- Fischer


- Wright

What does polyphenic mean?

- single gene produces multiple phenotypes

What methods are used to asses levels of genetic variation (3)?

- alozyme electrophoresis


- RELP


- Microsattelite analysis


Species:

smallest monophyletic group of common ancestry


Biological species concept:

group of individual fully fertile individuals incapable of breeding with other groups

Dobzansky and Mayr:

Biological species concepts

Evolutionary species concept:

species is single linneage w/ its own evolutionary tendencies and historical fate

Wiley:

Evolutionary species concept

Phylogenetic species concept:

cluser of organisms distinct from other such cluters and w/ a parental pattern of ancestry and descent

Cracaft:

Phylogenetic species concept

De Quieroz and Donoghue:

species

Recognition species concept:

most inclusive population of individual biparental organisms that share a common fertilization system

Patterson:

Recognition species concept

Cohesion Species Concept:

most inclusive population of individuals w/ potential for phenotypic cohesion thru intrinsic cohesion mechanisms

Templeton:

Cohesion Species Concept

Ecological species concept:

linneage that occupies an adaptive zone and evolves seperately from all other linneages

Van Valen:

Ecological species concept

Angenesis (2):

- microevolution


- evolutionary change w/ in linneages overtime

Cladogenesis (2):

- macroevolution


- splitting of linneages overtime


2 ways to identify species:

- Biological species concept


- Phylogenetic species concept

What are the 2 types of isolating barriers?

- geographic


- reproductive

Geographic barriers (2):

- extrinsic properties of landscape that prevent gene flow


- allopatry

Reproductive barriers (2):

- features of organisms that prevent interbreeding


- sympatry

Allopatric speciation (2):

- geographic isolation


- spatial restriction of gene flow


Vicariance (2):

- formerly widespread population becomes fragmented


- due to formation of mountains, rivers etc

Speciation:

- provides link b/w evolutionary change w/ in linneages and macroevolutionary patterns

Prezygotic gene flow barriers (6 examples):

- mates do not meet


- mates meet but don't mate


- temporal isolation


- habitat isolation


- copulation occurs but egg is not fertilized


- copulation occurs but gametes are not transferred

Premating barriers:

- timing of reproduction


ex - corals

Allochronic Speciation:

isolation due to life cycle timing differences

Postmating Barriers:

- genetic incompatibility

Genetic incompatibility:

sperm of one species fails to penetrate and fertilize egg of another species

Conspecific:

w/ in species


Heterospecific:

different species

Chromosomal sterility example:

horse and donkey produce sterile mule


According to Haldane, where is hybrid sterility usually found?

In the heterogametic sex

Bateson-Dobzhansky-Muller incompatibilities:

Occur when genomes of 2 species are combined in hybrid offspring

What provides an opportunity for allopatric speciation?

islands

What does colonization lead to?

speciation

Earnst Mayr (2):


Peripatric speciation


Genetic Revolution


Peripatric speciation (2):

- due to rare dispersal or colonization events


- aka "founder effect" speciation


What do drift and natural selection cause in small populations?

- rapid divergence from parental population


What are 2 forms of evidence of speciation?

- dispersal


- colonization


Genetic Revolution:

small populations will undergo a loss of genetic diversity by drift and will have it instead by mutation


Rassenkreis:

ring species

What happens in ring species?

populations at ends of rings cannot interbreed

What is an example of ring species?

Ensatina Eschscholotzi

What do changes in phylogeny lead to?

Reproductive isolation


Ecological speciation:

evolution of reproductive barriers due to adaptation to divergent environments

What 2 things happen when geographic barriers arise?

populations become allopatric


new species can arise

What does allopolyploidy lead to?

rapid speciation

What is the barcode of life?

use of DNA sequences as Taxon barcodes

Herbert Et al:

proposed that mtDNA serves as "Barcode marker" for the animal kingdom


Horizontal gene transfer (3):

- makes classification difficult


- genomes become mixed together


- creates WEB LIKE strands

Hybridization:

crosses b/w geneticall differentiated forms

Introgression:

- movement of genes b/w species, mediated by backcrossing

Bounded hybrid superiority model:

- narrow hybrid zone in which hybrids are more fit than parents

Corollary:

hybrids are less fit in parental habitats


Cruzan and Arnold:

mosaic model


Mosaic Model:

hybrid zones are mosaics due to the adaptation of 2 parental species


Tension Zones:

Characterized by significant linkage disquilibria

Adaptive Radation:

evolution of ecological and phenotypic diversity with rapidly multiplying linneage


Dolph Schluter:

Adaptive radiation

What are adaptive radiations characterized by (3)?

- ecological opportunity


- aquisition of novel adaptive traits


- parallel evolution


Character displacement:

members of one lineage constrain phenotypic evolution in members of other lineages

Polygenic trait:

influenced by many genetic loci

Epistasis

Interaction b/w alleles

Phenotypic plasticity

Gene interraction w/ envrionment

Quantitative:

means, variances, h2, VA

Qualitative:

p, q

Discontinuous traits:

traits w/ only a few phenotypes fall into discrete classes, phenotype controlled by one or few genes

Intermediate Dominance:

additive gene action

phenotypic variances:

total variance of population comes from genes and environment

Genetic variance

variance due to only genes

Calculating total penotypic variances

VP=VG+VE

VP:

total phenotypic variance in population

VG:

variance due to genetic differences

VE:

variance due to environmental differences

Broad sense heritability:

proportion of phenotypic viariance explained by genetic differences among individuals

Narrow sense heritability: (2)

- prop of phenotypic variance explained by additive genetic variation


- causes offspring to resemble parents

VA:

additive gene action

VD:

dominant gene action

VI:

epistatic gene action - 2 genes control a trait


Broad sense equation:

VP=VG+VE OR H^2 = VA/VP

Narrow Sense equation:

VG=VA+VD+VI OR H2=VA/VP

VP:

total phenotypic variance in population

VG:

Variance due to envrionmental differences

What is the range of heritabilities:

0-1

How can H2 be measured?

As the linnear relationship b/w parental and offspring traits

Disruptive selection:

turns into dual directional selection


How much the population changes depends on: (2)

- selection differential (s)


- heritability (H2)

Strong selection:

only the biggest individuals reproduce

Weak selection:

big and medium individuals reproduce


to calculate evolutionary repsonse to selection use:

breeders equation


Breeders Equation:

R=h2Xs

In breeders equation:H2

= heritability

In breeders equation: S

= selection differential

In breeders Equation: R

= response to selection

Selection differential:

difference b/w selected parents and population as a whole

Response to selection:

diff b/w selected offspring and unselected population

Phenotypic Plasticity:

single genotype produces diff. phenotypes depending on environment

Richard Wolterec:

reaction norm

What can rapid change lead to?

Mismatch b/w plastic traits and environment

Quantitative trait locus:

(QTL) - establishing linkage b/w traits and genes

Directional selection:

increases or decreases in the mean of the trait

Stabilizing selection:

favors average values of a trait

Eda:

involved in production of lateral plates in stickleback fish


Low Eda Allele:

favored in freshwater populations

Promiscuous patterns:

usually take on new functions after duplication

Paralogs:

homologous genes arise by duplication


What is often the starting point for novel traits?

Promiscuous proteins

Antagonistic Pleitropy:

# of cervical vertebrate

How many cervical vertebrate do most mammals have?

seven

Convergent evolution:

independent evolution of similar traits in different lineages


- result of similar selection pressures

Parallelism:

convergent evolution arises thru mutation of the same genes


Deep homology:

traits in diff lineages arise from same inherited regulatory networks

Twofold cost of sex:

asexual lineages can grow more rapidly than sexual lineages

Search-cost:

males and females must find each other - leads to risk of predation

Reduced relatedness:

sexual reproducing orgaisms pass only 1/2 alleles to offspring


Red Queen Effect:

makes sex beneficial

Anisogamy:

results in differential investment in reproduction

What limits females in reproductive success?

Fecundity

What limits males in reproductive success?

limited by # of mates they can obtain

Operational sex ratio

males:females capable of reproducing at a given time

Ornaments:

attractive traits that increase mating success

Armaments:

weaponry used to outcompete other individuals

Monogamy

1 male 1 female

Polygany

Male mates with numerous females

Polyandry

female mates with multiple males

High phosphorous in food in case study:

big daphnia

Low phosphorous in food in case study:

small daphnia

What will retard growth of Daphnia?

P limitation

In daphnia, who is more likely to provide parental care?

females

RA Fischer:

Frequency dependent selection


Trivers-Willard hypothesis:

daughters produced under poor conditions


sons produced under good contitions

Senescence (2)

- decline in surivival probability


- decline in age, specific reproductive rate

Antagonistic Pleiotropy theory:

sensecence occurs bc of pleiotropic effects of genes

How can we postpone senesense?

calorie restriction

What do older females benefit from?

Rearing children and grandchildren


Standing diversity:

# of species present in a certain area

Turnover rate:

extinction of some species and their replacement by others


Alpha:

origination rate

Omega:

extinction rate

Gingerich:

extinction rate often tracks origination rae

What are the 2 causes of mass extinction?

- drop in the origination rate, increase in the extinction rate


Biogeography:

study of geological patterns of diversity

Alfred L Wegner:

Continental drift theory

How can clades become isolated?

thru variance

How did marsupials evolve?

thru mix of vicariance and dispersal


Stephen Jay Gould and Niles Elderedge:

punctuated equilibrium

Punctuated Equlibirum:

All change directly associated w/ cladogenesis

Gradual evolution:

all character change is w/ in linneages

Copes Rule:

evolution tends towards size increase

Background Extinction:

normal rate of extinction

Five Mass Extinctions:

1) Ordovicarian


2) Devonian


3) Permian


4) Triassic


5) Cretaceous

Chiculub Meteor:

Struck earth at extinction event in cretaceous K/T period

Holocene:

present day period

What does increasing CO2 lead to?

warming temperatures


acidifying of the ocean

Intimate partnerships:

how species adapt to each other

Coevolution:

reciprocal evolutionary change b/w interacting species

Positive neutral commensalism:

one species benefits and the other is not effected


Hotspots:

selection is strong in both species

Coldspots:

no selection in one or borth species

What facilitates learned avoidance?

Mullerian Mimicry

Antagonistic Interactions:

involve frequency dependent selection that maintains genetic variation


What are mutualisms vulnerable to?

cheating

Endosymbionts:

mutualistic organisms that live w/in body of another organism

What 2 things are derived from free-living bacteria?

mitochondria and plant plastids

What makes up approximately 8% of the human genome?

endogenous retroviruses

Retrovirus:

RNA virus that uses reverse transcriptase to become part of its host's DNA

What is an example of a retrovirus?

HIV

What do neurons control?

behavior

How do sponges build sensory cells

by using proteins

Proximate:

how

Ultimate:

why

2 types of selection:

individual and group

What type of selection is more powerful?

individual

Game theory:

social conditions determine strategies

ESS:

evolutionary stable strategy


when adapted by a population of players it cannot be invaded by an alternative strategy

Sociality:

group living

Dilution effect:

safety in numbers - reduces risk of predation on any one individual

Eusociality:

species have complete division of labor

Haplodiploidity:

sex is determined by # of copies of each chromosome it receives

Coefficient of relatedness:

R


probability they share identical copies of a particular gene

Altruism:

inclusive fitness=direct fitness+ indirect fitness

Kin selection

indirect benefits of helping relatives

W.D. Hamilton

oxford proffesor


redefined fitness

Hamilton's Rule:

an altruistic allele increases in frequency when rB>C

In hamiltons rule R=

coefficient of relatedness b/w donor and recipient

In hamiltions rule B=

benefit to recipient from help

In hamiltons rule C=

Cost to donor for helping

Richard Dawkins:

Green Beard Effect

Green Beard Effect (3):

- recognisable phenotype


- ability to recognize phenotype


- preferential treatment to those w/ phenotype

Kin Selection theory:

will help relatives before non relatives


will help close relatives before distant ones

Synaptic Plasticity:

the neural mechanism of learning and memory

Anthromorphism

human motives or cultural characteristics ascribed to natural phenomena like animal behavior

What can social living influence?

Brain evolution

In what 2 species has tool use evolved?

Bird and mammals

Coalescence:

process by which the genealogy of any pair of homologous alleles merge in a common ancestor

Maximum parsimony tree:

simplest explantation

Distance Matrix Tree:

Clusters taxa based on genetic distances

Maximum likelihood tree:

Finds most likely tree given specific model of molecular evolution

Bayesian Methods tree:

looks at probability tree is correct given a specific model of molecular evolution

Neighbor Joining:

Minimizes total length of tree

What is the point of experimental phylogenies?

To validate methods

David Hill and Colleagues:

Used T7 Bacteriophage to study experimental phylogenetics

Multiregional Model:

old world hominins were single species connected by gene flow, multiregional differences were a result of adaptation

Motoo Kumura:

most evolution at molecular level is neutral b/c of genetic drift

Synonymous Substitutions:

do not change protein

Nonsynonymous subsitutions (2):

faster evolution indicates positive selection


slower evolution indicates purifying selection

KS:

# of synonymous substitutions per synonymous site

KA:

# of synonymous subsitutions per replacement site

Under neutral evolution:

KS=KA

Under positive selection:

Ks

Under purifying selection

Ks>KA

Micene Apes:

30 MYA


Gave rise to present day apes

When do the oldest fossil primates date to?

55 MYA

Tarsiers (3):

Carnivorous, nocturnal, from asia

Hominoids (6):

Brachiation, Erect, Flexible arms and shoulders, No tail, 5 molars

Orangs:

genus orango: fruit eaters, terrestrial

"Old man of the woods"

Orangs

Gorilla (3):

Small groups (10-20)


Polygyny


Males almost 2x the size of females

Chimpanzee:

Tool use


Puberty 8-10 years


Polygamous


Very social

Bonobo:

Not voilent


Females form hierarchy

Earliest stone tools:

Oldowan tools


Turkana Boy:

10-12 years old, 16 MYA, kenya

Java Man:

.75 MYA


H. Erectus

Peking Man:

China


.5 MYA


H. Erectus

Homo Heidelbergensil

Europe and Africa


700,000-200,000 years ago


Neanderthals:

Europe and Asia


300,000 years ago


bodies more stout and muscular than todays humans

Where is artificial selection evident?

in crop production


resulted in cob size increase in corn