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7 Cards in this Set
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possible causes of secondary amenorrhea
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pregancy
Hyperprolactinemia--galactorrhea multiple ducts, fat globules prolactin inhibts GnRH prolactomas, micro vs macro, treat with bromocriptine primary hypothyroidism drugs-reduces dopamine/blocks receptors reflex stimulation hyperandrogenic state cushings disease, PCOS obesity, insuling syndrome premature ovarian failure adrenal hyperplasia stress, loss of wieght, exercise Asherman's syndrome hypothalamic in orgin |
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secondary amenorrhea and avolution
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low estrogen, no LH surge, no ovulation, no LH and FSH to produce progestrone from corpus lutum--> bleeding amenorrhea
no bleed, no ovulation, (except ashermans) |
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Hyperprolactemia, amennorhea connections
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increased prolactin-->inhibits GnRH release-->no FSH,LH release-->no estrogen/progrestrin, no bleed.
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3 common causes of hyperprolacttineia
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prolactoma(micro, macro)
drugs-dopamine decreasing, dopamine blocking stimulation, primary hypothryroidism-->low t3-->increase TRH-->stim prolactin, release |
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obesity and amenorrhea
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insulin resistance-->obesity
also-->promotes elevated androgens-->avoloution-->polycystic kidneys-->theca cells-->androsterone-->decreased aromatase activity, suppress SHBG syn |
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chrom abnormalities and autoimmune diseases and POF
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CA: under 30, XO, streak gonads, women who are mosiacs, functional ovarian tissue
AD: depletion of ovarian follicles by autoimmune disease |
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asherman's syndrome
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endometrail lining is scarred by sugery or infection, endometritis, C-section, myomectomy, metroplasty, sab, post-partum.
ovulation, no menstral cycle |
