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9 Cards in this Set
- Front
- Back
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Where does oxidative phosphorylation occur?
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The mitochondria
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Describe a mitochondrion.
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Smooth outer membrane Highly folded inner membrane, the folds are known as cristae Electron transport and oxidative phosphorylation proteins are bound in the inner membrane The inner membrane is split into intermembrane space and the matrix |
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What is in the matrix of a mitochondrion?
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High concentrations of the soluble oxidative metabolism enzymes, substrates, nucleotide cofactors, inorganic ions.
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Briefly outline the mitochondrial ETC.
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1- NADH and FADH2 transfer their electrons to other substances, they become reoxidise (NAD+ and FADH). 2- The transferred electrons are involved in sequential redox reactions of redox centres in four enzyme complexes before reducing O2. 3- In the ETC protons are expelled from mitochondrion to produce a proton gradient across the membrane. This free energy of this electrochemical gradient drives ATP synthesis through oxidative phosphorylation. |
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What is permeable to the inner membrane?
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O2, CO2 and H2O. Transport of other ions and molecules requires transport proteins.
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Can NADH pass through the inner-membrane?
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No it lacks the transporter for it so it must be transferred via a shuttle system. Only the electrons are transferred Aka. the malate-aspartate shuttle system |
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How are ADP and ATP transferred from cytosol to mitochondrial matrix and vice versa?
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ADP-ATP exchange translocator
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What inhibits the ADP-ATP translocator?
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Atracyloside, carboxyatracyloside, bongkrekic acid
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