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10 Cards in this Set

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  • Back
Tissue repair is the restoration of damaged tissue with:
Tissue renewal/Regeneration - replaces lost cells with same type cells; function maintained.
Fibrosis/scarring - damaged tissue replaced with connective scar tissue consisting of collagen, function often lost
Parenchymal tissue
Functioning cells of an organ
What is stromal tissue?
supporting connective tissues
extracellular matrix
Blood vessels
nerves
How does tissue repair occur?
Cellular proliferation by mitotic production of new cells; daughter cells are same as original cells
What controls cell proliferation?
Cellular proliferation is controlled by mitotic factors called growth factors that bind to surface receptors and initiate mitosis
What are the 4 major phases of the cell cycle?
G1 - cell components begin to prepare for division
S (synthesis) - DNA replication
G2 - organelles double, cytoplasmic components and cytoskeleton increases, prepare for division
M - cellular division, prophase, metaphase, anaphase, telophase and cytokinesis
G0 - cell permanently exits cell cycle
Name the three division of body tissues.
Continuously doubling (epithelial)
Stable (skeletal, skeletal muscle)
Permanent (central nervous system, neurons)
Name three properties of stem cells.
1. Self-renewal - keep dividing
2. Asymmetric replication - always one daughter cell kept, other cell matures
3. Differential potential (potency) - one cell differentiates to different levels
What are the different potencies of stem cells?
Totipotent - can make all tissue types
Pluripotent - can make cells from a germ layer
Multipotent - can make a family of cells, differentiated to a specific line
Unipotent - one cell type, specific to one organ
What are the properties of embryonic stem cells?
From early stage embryo
Pluripotent cells from inner mass of blastocyst
Can generate multiple cell lines