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22 Cards in this Set
- Front
- Back
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Name 4 basic types of tissues
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-muscle
-epithelia -CT -nervous |
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Structural characteristics of epi
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-lots of cells tightly linked
-sidedness:lat,basal,apical -junct. complexes (contacts) -gap junct.(communication) -BL -basal cell mitosis -no bld vessels |
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Functional characteristics of epi
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-transcelluar transport:
*diff of O2 & CO2->lungs *carrier proteins mediated transport->intestines *vesicle transport of meds -absorption=endocyt./pinocyt. -secretion=exocyt. -selective permeability=tight junct. -protection |
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Simple cuboidal epi
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-same ht./wd.
-spherical nuc in cntr. -in glands/kidney/ovary -lines ducts -secretion/absorption |
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Simple squamous epi
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-flat
-nuc in cntr -lines: bld vess,capillaries,bowmans capsule -in lungs endothelial layer for fluid & gas exchange |
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Simple columnar epi
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-tall
-ovid nuc @ base -secretion,absorption (goblet cells) -ducts of glands -lines GI tract -has microvilli |
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Pseudo strat. columnar epi
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-not all cells on surface
-several layers of nuclei -crowded cells -all touch BL -protective lining,secretory,absorption -resp tract/epididymus/vas def./trachea/nasal passage -has stereocillia |
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Strat. squamous epi
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-more than 1 cell layer
-lines mouth,esoph,GI tract 2 types: keratinized-skin nonkeratinized-mucous |
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Strat. cuboidal epi
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-sweat ducts
-2 layers |
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Strat columnar epi
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-salivary glands
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Transitional epi
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2phases:
relaxed-cuboidal flat-distended -bladder/ureters |
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Classes of glands
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-endocrine->directly to bld,cell stimulates itself
-paracrine->target cell close by -exocrine-> have ducts |
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Exocrine gland classification
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-unicellular/multicellular
(goblet cell/pancreas) -simple/compound ducts -tubular/tubulo/alveolar shaped secretion unit -mucous/serous sec. prod -mode of sec: holocrine-whole cell w/ sec is released (sebaceous gland) merocrine-exocyt. apocrine-cytoplasm releases w/ contents (mammory glnd) |
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Surface specialization of epi
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-stereocillia: long microvilli,only in epididymus & cochlea
-microvilli: made of glycocalyx *brush border=kidney,coats surfaces,has actin filiments in core *striated border=intestines/ actin filiments -cillia:ovaduct,have core of microtubules -flagella:sperm |
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Junctions that allow for cell comm. & binding
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Binding:
-zona occludens -zona adherins -macula adherins communicating: -gap junct. |
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Zona occludens
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-diffusion barrier
-H2O can't pass b/t cells -keeps memb. proteins from moving to base of cell w/ claudins,laminin,occludens -binds to microfiliments -linkers Zo1,Zo2,Zo3 are affected by cytomegalovirus & cholera:PM becomes permeable |
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Zona adherens
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-below tight junct.
-helps cell w/ mech. & structure -fuzzy area on inside of PM -dep on Ca -bind to E cadheren & actin -intermediate junct. |
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Macula adherens
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-throughout cell along PM
-made of desoplakin & pakoglobins -in cadhern family -Ca dep -desmosomes |
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Functions of basal lamina
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-structure attachment for epi
-interactions w/ other cells -selective barrier -movement durig dev |
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2 zones of BL
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zona lucida (rara):
-next to PM -has laminin -collagen 4 zona densa: -next to reticular lamina -proteoglycan(has extensions of GAGs) ->makes perlacan-> has chains of hep sulfate -coll 4 |
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Lamina reticularis
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-attaches to lamina densa
-made of: coll 4 anchoring fibrils fibrillin microfibrils coll 2 reticular fibers |
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Hemidesmosomes
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attachment to base of cell to BL & underlying extracellular matrix
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