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9 Cards in this Set
- Front
- Back
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Describe DNA methylation? |
Covalent modifications of mammalian DNA occurring via the methylation of cytosine, typically in the context of the CpG dinucleotide. |
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What are Epigenetics? |
The study of heritable changes in gene expression or cellular phenotype caused by mechanisms other than changes in underlying DNA sequence. |
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What is an Epigenome? |
The genome-wide distribution of epigenetic marks |
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What is a Gene? |
A specific DNA sequence that codes for a specific polypeptide or protein or an observable inherited trait |
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Describe the Genome Wide Association Study |
Study that maps DNA polymorphisms in affected individuals and controls matched for age, sex, and ethnic backgrounds-with the aim of identifying causal genetic variants |
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What is a Genotype? |
The DNA content of a cell’s nucleus, whether a trait is externally observable or not |
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Histone Modifications |
Post-translational modifications of the N-terminal “tails” of histone proteins that serve as a major mode of Epigenetic regulation |
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Identical twins |
Two individuals that originated from the same zygote and are genetically identical or very similar |
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What is a Phenotype? |
Pattern of expression of the genotype or the magnitude or extent to which it is observably expressed. an observable characteristic or trait of an organism |
