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48 Cards in this Set

  • Front
  • Back
what is epidemiology
“The study of the distribution and
determinants of disease frequency in
populations, and the application of
this study to control health
problems.”
internal validity
The ability of a study to measure
what it sets out to measure
external validity
Usual tactic: choose a sample, study it, and,
hopefully, extrapolate the results to the
general population
random error
Random error is always present in a measurement. It is caused by inherently unpredictable fluctuations in the readings of a measurement apparatus or in the experimenter's interpretation of the instrumental reading.
two types of error:
1. systematic:due to bias
2. random due to chance
types of bias
information
confounding
selection
the process of making something random
randomization
may focus on individual-level measures, or on emergent social properties that have no correlate at the individual level
social epidemiology
usually includes communicable diseases
infectuous diseases
denotes a necessary relationship between one event (called cause) and another event (called effect) which is the direct consequence of the first
causality
is associated with the probable cause and the outcome
confounder
Mixing of the effect of the exposure on disease with the effect of another factor that is associated with the exposure
confounder
criteria for a confounder
1 A confounder must be a cause of the disease (or a marker for a cause)
2 A confounder must be associated with the exposure in the source population
3 A confounder must not be affected by the exposure or the disease
denotes the relationship betweenc onec event (the cause) and (the effect)
causality
An outbreak that does not have a common source, but instead spreads from person to person.
propagated outbreak
comes from an ideal understandk\ing
common source outbreak
Changes in one of the elements of the triangle can influence the occurrence of disease by increasing or decreasing a person’s risk for disease.
deals with the 3 corners of the epu triangle
an outcome from th epidemiological triangle
Risk is understood as the probability an individual will become ill..
what are the 3 corners of the epi triangle
1. environment
2. host
3. agent
GIS? and what part of health is it used
geographic information systems, public health
describes a type of immunity that occurs when the vaccination of a portion of the population (or herd) provides protection to unprotected individuals
herd immunity
evaluates and catalogs all the circumstances surrounding a person affected by a health event of interest.
descriptive epidemiology
what is similar between a rate, ratio and proportion
they are all fractioned
odds ratio
(A / B)/(C / D)
relative risk
(a / b) / (c / d) OR (a * d) / (b * c)
Privides a snap shot
Is simple
Provides associated factor
Is first line of epidemiologic research
cross sectional
what is a cross sectional study about concerning morbidity
complications
what is a cross sectional study about concerning mortality
deaths
How is it a cross sectional study diffrent?
different about:
SES
Age at onset
Season
is a measure of the risk of developing some new condition within a specified period of time
Incidence
prevalence
total # of cases
a retrospective study
goes from the case backward to find rhe cause
pros of a retrospective study
Suitable for rare diseases
Inexpensive
Minimal ethical problems
Short study time
Small # of subjects
Subjects need not volunteer
disadvantages cross sectional
Disadvantages:

* establishes association at most, not causality;
* recall bias susceptibility;
* confounders may be unequally distributed;
* Neyman bias;
* group sizes may be unequal.
disadvantages cohort
Disadvantages:

* controls may be difficult to identify;
* exposure may be linked to a hidden confounder;
* blinding is difficult;
* randomisation not present;
* for rare disease, large sample sizes or long follow-up necessary.
disadvantage randomized
Disadvantages:

* expensive: time and money;
* volunteer bias;
* ethically problematic at times
disadvantages crossover
Disadvantages:

* all subjects receive placebo or alternative treatment at some point;
* washout period lengthy or unknown;
* cannot be used for treatments with permanent effects
disadvantages case control
Disadvantages:

* reliance on recall or records to determine exposure status;
* confounders;
* selection of control groups is difficult;
* potential bias: recall, selection.
advantages cross sectional
Advantages:

* cheap and simple;
* ethically safe
advantages cohort
Advantages:

* ethically safe;
* subjects can be matched;
* can establish timing and directionality of events;
* eligibility criteria and outcome assessments can be standardised;
* administratively easier and cheaper than RCT.
advantages cross sectional
Advantages:

* cheap and simple;
* ethically safe.
advantages cohort
Advantages:

* ethically safe;
* subjects can be matched;
* can establish timing and directionality of events;
* eligibility criteria and outcome assessments can be standardised;
* administratively easier and cheaper than RCT.
advantages case control
Advantages:

* quick and cheap;
* only feasible method for very rare disorders or those with long lag between exposure and outcome;
* fewer subjects needed than cross-sectional studies.
advantages randomized
Advantages:

* unbiased distribution of confounders;
* blinding more likely;
* randomisation facilitates statistical analysis.
advantages crossover
Advantages:

* all subjects serve as own controls and error variance is reduced thus reducing sample size needed;
* all subjects receive treatment (at least some of the time);
* statistical tests assuming randomisation can be used;
* blinding can be maintained.
Primary Prevention
Those activities that decrease the likelihood of abuse ever happening in the first instance.
Secondary Prevention
Those activities that reduce the likelihood that abuse will continue or reoccur.
Tertiary Prevention
Those activities that seek, over time, to ameliorate or lessen the harm already done as a result of the illness