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48 Cards in this Set
- Front
- Back
what is epidemiology
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“The study of the distribution and
determinants of disease frequency in populations, and the application of this study to control health problems.” |
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internal validity
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The ability of a study to measure
what it sets out to measure |
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external validity
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Usual tactic: choose a sample, study it, and,
hopefully, extrapolate the results to the general population |
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random error
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Random error is always present in a measurement. It is caused by inherently unpredictable fluctuations in the readings of a measurement apparatus or in the experimenter's interpretation of the instrumental reading.
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two types of error:
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1. systematic:due to bias
2. random due to chance |
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types of bias
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information
confounding selection |
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the process of making something random
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randomization
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may focus on individual-level measures, or on emergent social properties that have no correlate at the individual level
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social epidemiology
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usually includes communicable diseases
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infectuous diseases
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denotes a necessary relationship between one event (called cause) and another event (called effect) which is the direct consequence of the first
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causality
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is associated with the probable cause and the outcome
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confounder
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Mixing of the effect of the exposure on disease with the effect of another factor that is associated with the exposure
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confounder
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criteria for a confounder
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1 A confounder must be a cause of the disease (or a marker for a cause)
2 A confounder must be associated with the exposure in the source population 3 A confounder must not be affected by the exposure or the disease |
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denotes the relationship betweenc onec event (the cause) and (the effect)
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causality
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An outbreak that does not have a common source, but instead spreads from person to person.
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propagated outbreak
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comes from an ideal understandk\ing
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common source outbreak
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Changes in one of the elements of the triangle can influence the occurrence of disease by increasing or decreasing a person’s risk for disease.
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deals with the 3 corners of the epu triangle
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an outcome from th epidemiological triangle
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Risk is understood as the probability an individual will become ill..
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what are the 3 corners of the epi triangle
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1. environment
2. host 3. agent |
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GIS? and what part of health is it used
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geographic information systems, public health
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describes a type of immunity that occurs when the vaccination of a portion of the population (or herd) provides protection to unprotected individuals
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herd immunity
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evaluates and catalogs all the circumstances surrounding a person affected by a health event of interest.
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descriptive epidemiology
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what is similar between a rate, ratio and proportion
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they are all fractioned
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odds ratio
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(A / B)/(C / D)
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relative risk
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(a / b) / (c / d) OR (a * d) / (b * c)
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Privides a snap shot
Is simple Provides associated factor Is first line of epidemiologic research |
cross sectional
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what is a cross sectional study about concerning morbidity
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complications
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what is a cross sectional study about concerning mortality
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deaths
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How is it a cross sectional study diffrent?
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different about:
SES Age at onset Season |
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is a measure of the risk of developing some new condition within a specified period of time
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Incidence
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prevalence
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total # of cases
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a retrospective study
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goes from the case backward to find rhe cause
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pros of a retrospective study
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Suitable for rare diseases
Inexpensive Minimal ethical problems Short study time Small # of subjects Subjects need not volunteer |
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disadvantages cross sectional
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Disadvantages:
* establishes association at most, not causality; * recall bias susceptibility; * confounders may be unequally distributed; * Neyman bias; * group sizes may be unequal. |
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disadvantages cohort
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Disadvantages:
* controls may be difficult to identify; * exposure may be linked to a hidden confounder; * blinding is difficult; * randomisation not present; * for rare disease, large sample sizes or long follow-up necessary. |
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disadvantage randomized
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Disadvantages:
* expensive: time and money; * volunteer bias; * ethically problematic at times |
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disadvantages crossover
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Disadvantages:
* all subjects receive placebo or alternative treatment at some point; * washout period lengthy or unknown; * cannot be used for treatments with permanent effects |
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disadvantages case control
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Disadvantages:
* reliance on recall or records to determine exposure status; * confounders; * selection of control groups is difficult; * potential bias: recall, selection. |
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advantages cross sectional
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Advantages:
* cheap and simple; * ethically safe |
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advantages cohort
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Advantages:
* ethically safe; * subjects can be matched; * can establish timing and directionality of events; * eligibility criteria and outcome assessments can be standardised; * administratively easier and cheaper than RCT. |
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advantages cross sectional
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Advantages:
* cheap and simple; * ethically safe. |
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advantages cohort
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Advantages:
* ethically safe; * subjects can be matched; * can establish timing and directionality of events; * eligibility criteria and outcome assessments can be standardised; * administratively easier and cheaper than RCT. |
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advantages case control
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Advantages:
* quick and cheap; * only feasible method for very rare disorders or those with long lag between exposure and outcome; * fewer subjects needed than cross-sectional studies. |
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advantages randomized
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Advantages:
* unbiased distribution of confounders; * blinding more likely; * randomisation facilitates statistical analysis. |
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advantages crossover
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Advantages:
* all subjects serve as own controls and error variance is reduced thus reducing sample size needed; * all subjects receive treatment (at least some of the time); * statistical tests assuming randomisation can be used; * blinding can be maintained. |
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Primary Prevention
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Those activities that decrease the likelihood of abuse ever happening in the first instance.
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Secondary Prevention
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Those activities that reduce the likelihood that abuse will continue or reoccur.
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Tertiary Prevention
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Those activities that seek, over time, to ameliorate or lessen the harm already done as a result of the illness
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