Eosinophilia In Tropics

Front 1

Eosinophils:
........
Acute inflammation stimulates neutrophil production and inhibits eosinophils causing eosinopenia (also: stress, acute infection, trauma, burn, acromegaly, and corticosteroid).
Eosinophilic stimulation follows repeated and /or prolonged antigen exposure (especially Ag deposited in tissue) which are T-lymphocyte dependent where lymphocytes release substance stimulates eosinopoiesis, eosinophilopoietin which stimulates BM Precursor cells to produce mature eosinophils i.e. eosinophilia.

Back 1

They are granulocytic leucocytes and are similar to neutrophils in: life cycle, morphology, enzymes, metabolism and phagocytosis.

Front 2

Eosinophilia: is usually temporary and not harmful but ...... could be harmful (with no apparent cause) causing what is called: .... affecting organ systems (ex: hypereosinophilic syndrome, eosinophilic leukemia, Loffler’s endomyocardial disease and prolonged pulmonary eosinophilia).

Back 2

-marked prolonged eosinophilia
-Eosinophilic syndromes
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-

Front 3

Eosinophilia: is one of the .....haematological laboratory findings in patients seen in tropics (secondary to ....) and in .... as well as newly arrived immigrants from developing countries. Although eosinophilia itself is rarely harmful, it is often a clue to the underlying parasitic infection.

Back 3

-most common
-anaemia
-travelers
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Front 4

Conditions that are frequently associated with eosinophilia:
Common:
....such as: hay fever, urticaria and asthma.
..... infection (will be discussed later).
Drugs as:......
Collagen vascular diseases as: allergic angiitis, fasciitis and
polyarteritis nodosa.
Gastrointestinal: eosinophilic gastroenteritis.
Eosinophilic syndromes.

Back 4

-Allergy
-Parasitic
-iodides, erythromycin and sulfonamides
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-

Front 5

Occasional - :
.... infection as: aspergillosis and coccidioidomycosis.
Mycobacterial: T.B.
Malignancies: lymphoma, solid tumors of lungs and stomach.
Post irradiation.
Miscellaneous: chronic peritoneal, dialysis, chronic active hepatitis, acute pancreatitis, insect bites and eosinophilic meningitis.

Back 5

-Fungal
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-
-
-

Front 6

Tissue-invading worm infections that associated with eosinophilia
Tissue Nematodes
Blood and lymphatics

Back 6

Wuchereria bancrofti
Brugia malayi

Front 7

Tissue-invading worm infections that associated with eosinophilia
Tissue Nematodes
Skin & subcutaneous

Back 7

Loa loa
Onchocerca volvulus
Dracunculus medinensis
Ancylostoma braziliense

Front 8

Tissue-invading worm infections that associated with eosinophilia
Tissue Nematodes
Gut

Back 8

Strongyloides stercoralis

Front 9

Tissue-invading worm infections that associated with eosinophilia
Tissue Nematodes
Lung

Back 9

-Migrating larva of:
Ascaris lumbricoides
Nector americanus
Ancylostoma duodenale
Strongyloides stercoralis
Toxocara canis
Toxocara catis
-Tropical pulmonary eosinophilia

Front 10

Tissue-invading worm infections that associated with eosinophilia
Tissue Nematodes
Liver

Back 10

Toxocara canis & catis→ VLM
Capillaria hepatica

Front 11

Tissue-invading worm infections that associated with eosinophilia
Tissue Nematodes
Muscle

Back 11

Angiostrongylus cantonensis

Front 12

Tissue-invading worm infections that associated with eosinophilia
Tissue Nematodes
Brain

Back 12

Trichinella spiralis

Front 13

Tissue-invading worm infections that associated with eosinophilia
Tissue trematodes
Liver

Back 13

Schistosoma mansoni (blood)
Schistosoma japonicum(blood)
Fasciola hepatica & gigantica

Front 14

Tissue-invading worm infections that associated with eosinophilia Tissue trematodes
Lung

Back 14

Paragonimus westermani

Front 15

Tissue-invading worm infections that associated with eosinophilia
Tissue trematodes
Urinary tract

Back 15

Schistosoma haematobium

Front 16

Tissue-invading worm infections that associated with eosinophilia
Tissue cestodes
Liver, lung and brain

Back 16

Echinococcus granulosus