Enzymology P3

Front 1

GGT

Back 1

GGT levels normal in the presence of bone disease and during pregnancy in contrast to alkaline phosphatase where levels would be elevated

Front 2

differentiate liver disorder (OJ) from bone disorder (Paget)

Back 2

GGT is a marker used together with ALP to

Front 3

GGT is a test for

Back 3

occult alcoholism

Front 4

phenobarbital and phenytoin

Back 4

GGT activity induced by drugs are caused by

Front 5

Gamma-Glutamyl Transferase

Back 5

What is GGT

Front 6

Phosphoric monoester hydrolase

Back 6

5’ NT predominantly secreted from the liver

Front 7

5’ Nucleotidase (5’-NT)

Back 7

Differential test for serum ALP

Front 8

cholestatic disorder

Back 8

5’ Nucleotidase is increased in

Front 9

- Acetylcholinesterase (AChE)

- Acetylcholine acylhydrolase

Back 9

Cholinesterase Two Related Enzyme

Front 10

Acetylcholinesterase (AChE)

Back 10

● True Cholinesterase

● Found in red blood cells, lungs, spleen, nerve endings, and gray matter of the brain

Front 11

Pseudocholinesterase PChE

or

butyrylcholinesterase (BuChe)

Back 11

Other term for Acetylcholine acylhydrolase

Front 12

Acetylcholine acylhydrolase

Back 12

● AKA Pseudocholinesterase PChE or butyrylcholinesterase (BuChe)

● Found in liver, pancreas, heart, white matter of the brain, and serum

Front 13

increased

Back 13

PChE found in serum is normally

Front 14

Pseudocholinesterase

Back 14

Decreased amount in hepatocellular disease (cirrhosis, hepatitis) due to decrease synthesis

Front 15

- hepatocellular disease (cirrhosis, hepatitis)

- insecticide poisoning/organophosphate poisoning

Back 15

Pseudocholinesterase decreased amount in

Front 16

risk of prolonged response to muscle relaxants

Back 16

PChE testing identifies individuals with a typical forms who are at

Front 17

succinylcholine and mivacurium

Back 17

PChE deficiency results in abnormally slow metabolic degradation of exogenous choline ester drugs such as

Front 18

peptidyl-dipeptidase A or kininase II

Back 18

Angiotensin – Converting Enzyme (ACE) AKA

(PDA Kayong 2!)

Front 19

Angiotensin – Converting Enzyme (ACE)

Back 19

It is as aspartic acid protease

Front 20

Angiotensin – Converting Enzyme (ACE)

Back 20

A hydrolase enzyme that requires zinc for activation

Front 21

vascular endothelium of lungs and kidney

Back 21

ACE is found mainly in the

Front 22

Aspartic acid protease

Back 22

a proteolytic enzyme ( enzymes that breaks down protein)

Front 23

Renin-angiotensin system

Back 23

regulation of blood pressure

Front 24

Angiotensin Converting Enzyme

Back 24

Component of renin – angiotensin system

Front 25

ACE

Back 25

Component of renin – angiotensin system

Front 26

SARCOIDOSIS

Back 26

ACE is a diagnostic test for

Front 27

neural dysfunction (Alzheimer’s disease)

Back 27

ACE is a possible indicator of

Front 28

ACE2

Back 28

cellular receptor for SARS and SARS-CoV-2

Front 29

Glucose-6-Phosphate Dehydrogenase (G-6-PD)

Back 29

● Functions to maintain NADPH in the reduced form in the erythrocytes

● Newborn screening marker

Front 30

G6PD

Back 30

Deficiency can lead to drug-induced hemolytic anemia (primaquine, antimalarial drug)

Front 31

primaquine

antimalarial drug

Back 31

G6PD is caused by

Front 32

RBC’s

spleen

lymph nodes

adrenal cortex

Back 32

Source of G6PD

Front 33

MI and Megaloblastic anemia

Back 33

G6PD is increased in

Front 34

● Red cell hemolysate and serum

Back 34

Required Sample for G6PD

Front 35

Ceruloplasmin

Back 35

Copper – carrying protein with an enzymatic activity

Front 36

Wilson Disease (hepatolenticular disease)

Back 36

Ceruloplasmin is a Marker of

Front 37

Kayser-Fleischer Ring

Back 37

Cornea

Front 38

Ornithinecarbamoyltransferase (OCT)

Back 38

● Marker for hepatobiliary disease

● Serum concentration: useful marker for disease severity and useful marker for High Risk HepaC

Front 39

Serum concentration

Back 39

useful marker for disease severity and useful marker for High Risk HepaC

Front 40

hepatobiliary disease and High Risk HepaC (serum level)

Back 40

Ornithinecarbamoyltransferase (OCT) is increased in

Front 41

Trypsin

Back 41

●Produced in secretory granules of the pancreatic acinar cell

● Serves as an activator of digestive proenzyme

● Inactive trypsinogen in the acinar cells

● More specific than amylase in pancreatitis

Front 42

Trypsin

Back 42

Serves as an activator of digestive proenzyme