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7 Cards in this Set
- Front
- Back
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What is the definition of enzymes?
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Proteins that catalyze chemical reactions
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True or false. All species tend to have the same distribution of enzymes.
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False, different animal species may have different distribution of enzymes
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What are isozymes?
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Proteins that have different polypeptide structures but catalyze the same chemical reaction
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What are 3 causes of increased serum enzyme activity?
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1) Release from injured cells
2) Increased production -Induction of a membrane-bound enzyme -Hyperplasia or neoplasia of cell of origin 3) Decreased removal e.g. renal failure and enzymes normally cleared through kidney |
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What are the 6 factors affecting the degree of increased enzyme activity?
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1) Concentration in cell
2) Intracellular distribution 3) Severity of cell damage 4) Number of cells damaged 5) Plasma half life of enzyme 6) Does the enzyme get into the plasma? |
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What is the significance of decreased enzyme activity?
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Usually no diagnostic importance
e.g. Alkaline phosphatase can be low sometimes and its NOT significant |
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How are enzymes usually measured? Reported?
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Measured by activity (NOT concentration)
Reported as U/L or mU/L -1 U=1 umol/min |
