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13 Cards in this Set
- Front
- Back
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What are coenzymes?
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complex nonprotein organice molecules that help catalyze reactions with specific classes of substrates or just play a structural role
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What are the most common oxidation reduction coenzymes?
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NAD, FAD and NADP
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What is an apoenzyme?
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an enzyme without its nonprotein component, its inactive
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What is a haloenzyme?
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an enzyme WITH its nonprotein component, it is ACTIVE
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What do activation transfer enzymes do?
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usually directly form covalent bonds with substrates and then transfer or spur another reaction
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What are two common activation transfer enzymes?
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biotin and CoA
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How do oxidation reduction coenzymes work?
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similar to activation transfer but don't form covalent bonds w/ substrate. Each has a unique functional goup that it uses to move electrons around
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Hydrides, protons and oxygen are transferred via what type of coenzyme?
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oxidation reduction
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What type of inhibitors mimic or participate in the intermediate steps of a catalytic reaction?
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mechanism based inhbitors
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How do covalent inhibitors work?
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form covalent bonds with residues in the active site
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What are three examples of covalent inhbitors?
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sarin, malathion and parathion
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How is activity resumed after covalent inhibitors attack?
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activity only resumed after new enzymes have been made
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Penicilin is what type of inhibitor?
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transition state analogs (type of mechanism based inhibitor)
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