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35 Cards in this Set
- Front
- Back
What do enzymes do?
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lower activation engery
catalyze reactions |
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What is the shape of enzymes?
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all are globular
|
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When do enzymes work best?
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37'C
|
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vivo
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inside organism
|
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Kinase
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PO4
takes energy |
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Ligase
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bonds
|
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If you lower the temperature
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slower process
|
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if you raise the temperture
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you can denature the enzyme
(fever raises temperature to kill bacteria) |
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pH of an enzyme?
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each enzyme works best at its own special pH
|
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pepsin
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stomach
pH 1.8 digestive protease |
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Chymotrypsin
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small intestines
pH 8.9 |
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thrombosin
|
blood
pH 7.4 |
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How do enymes work?
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1. they attract substrated them (they dont have to wait for collisions to occue and they dont have to raise temp too high to get molecules moving)
2. They bring substrates together at the correct orientation (donat have to wait for substrates to just hiteach other at the right angle) |
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Active Site
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th epoint at which the thingy you aregoing to destroy laches on
|
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substraight
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the thing destroying
|
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Two main kinds of activators (helper)
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1. cofactors (small inorgainc molecules)
2. coenzymes (small orgainc molecules) |
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What are examples of coenzymes
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NAD+ and FAD2+
|
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B1 defietcy
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Beriberi wasting
|
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NAD+ def
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Pellagra light sens. (vampires)
|
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Substrates
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dont fit well
|
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Apoenzyme
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without a cofactor
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why do you add cofactors orcoenzymes?
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so it fits better
|
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two models of enzyme
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lock and key
induced fit |
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isoenzyme
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same enzyme but chemicall slightly different
|
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CPK
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creative phospho kinase
|
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MM
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high % in skeletal muscles
|
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MB
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high% in heart muscles
|
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BB
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very little in any tissue
|
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MI
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myocardial infraction
heart attack |
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what increase in MI
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MB
|
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subunits of CPK
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2
|
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LD
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Lactase dehydrogenase or LDH
exists in 5 forms each differ slightly in structure (isoenzyme) |
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Vmax
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the maximun rate at which they can catalyze a reaction
|
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limiting reagent
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substrate
|
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poison
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super glue
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