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8 Cards in this Set
- Front
- Back
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What are the mixed MEN syndromes?
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Von hippel-lindau syndrome- Pheo, RCC, hemangioblastoma, retinal angiomas
Carney complex- mixoma, brown spotting skin lesion, testicular tumors, endocrinopathy |
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MEN 1 aka? inheritance?
Most common manifestation of MEN 1? gene? |
aka Wermer's AD
MEN1 gene presents with hyperparathyroidsim |
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What % of MEN1 is malignant features of pancreas?
How do you dx? tx? |
1/3
- dx with high resolution CT, endoscopic ultrasound - resectino of tumor producing insulin, glucagon, VIP, GHRH, CRH, gastrinoma, H2 receptor blocker, PPI, total pancreatectomy |
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In MEN1 what are surgical indications when they have hyperparathyroidism
What type of surgery is done? |
– Serum Ca > 12 mg/dl
– Calcium Nephrolithiasis – Renal dysfunction – Osteopenia – Neuropathic /muscular symptoms Surgery- total parathyroidectomy, but remnants are implanted in forearm |
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Prolactinomas medical treatment?
Acromegaly medical treatment? |
dopamine agonist (Bromocryptine)
- octriotide, regvisomant |
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MC presentation in pt with MEN2A?
MC histo findings? |
medullary carcinoma of the thyroid
- multiglandular parathyroid hyperplasia |
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Most distinctive features of MEN2B?
Screening? |
mucosal neuromas and Marfanoid habitus
- genetic testing for RET protooncogene, annual calcitonin provocative testing |
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Tx of MEN2B
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Total thyroidectomy with central lympn node dissection in children
who carry the mutant gene - external radiation in case of metastatic disease |
