Enteric 2

Front 1

T/F E. Coli ferments lactose?

Back 1

TRUE;

Front 2

These E. Coli are responsible for travelers diarrhea and children's diarrhea?

Back 2

ETEC

Front 3

This E.coli shows bacillary dysentary similar to shigella?

Back 3

EIEC

Front 4

This E. Coli shows infant diarrhea?

Back 4

EPEC; also EAEC

Front 5

This E. Coli produce shiga toxin and displays hemorrhagic colitis and Hemolytic Uremic Syndrome?

Back 5

EHEC/STEC

Front 6

What are the steps of pathogenesis for ETEC?

Back 6

ingestion (food/water - human feces) > colonization small intestine (colinization fimbria CFA and CS) > elaboration of enterotoxins (ST and LT)

Front 7

ETEC (watery diarrhea or inflammatory diarrhea)?

Back 7

Watery

Front 8

CF, LT and ST genes (virulence factors) are encoded where in ETEC?

Back 8

Large plasmids

Front 9

What is the mechanism of action of the ST and LT enterotoxins in ETEC?

Back 9

increase in cAMP and cGMP

Front 10

What pathogen is responsible 30-57% of diarrhea among military personnel in African and mid east?

Back 10

ETEC

Front 11

ETEC (is there blood in stool)?

Back 11

NO

Front 12

In ETEC, immunity to endemic serotyopes leads to adult immunity T/F?

Back 12

TRUE;

Front 13

ETEC (intracellular or extracellular)?

Back 13

Extracellular; antibody

Front 14

What is the major difficulty in developing vaccine for ETEC?

Back 14

variety of serotypes

Front 15

This E. coli is identical to shigella disease (range of watery diarrhea to dysentery); has a lrage shigella virulence plasmid; World-wide and common in children?

Back 15

EIEC (enteroinvasive)

Front 16

This E.Coli is a major pathogen and cause of acute and chronic diarrhea in infants < 2 years old; and is a true age-restricted pathogen?

Back 16

EPEC

Front 17

T/F breast milk is protective for EPEC?

Back 17

TRUE;

Front 18

The gene for the bundle-forming pillus involved in the intial adherence of EPEC to Small Intestin mucosa is located where in the bacteria?

Back 18

Virulence plasmid

Front 19

What is the Late (intimate) adherence of EPEC mediated by, and where are these factors encoded?

Back 19

Intimin; encoded on a chromosomal pathogenicity island

Front 20

What are the symptoms of hemorrhagic colitis?

Back 20

abd pain; NO FEVER; bloody diarrhea; VARIABLE presence of fecal PMN

Front 21

microangiopathic hemolytic anemia, thrombocytopenia, glomerular thrombosis

Front 22

EHEC such as E. coli 157 has attaching and effacing intestinal lesion which are encoded where in the chromosome?

Back 22

Pathogenicity island

Front 23

The shiga toxin produced by EHEC is bacteriophage produced T/F?

Back 23

TRUE;

Front 24

What is the difference between STEC and EHEC?

Back 24

STEC has no intimin and no LEE (pathogenicity island); Both have bacteriophage encoded shiga toxin

Front 25

What does shiga toxin bind to in glomeruli?

Back 25

Gb3 receptor

Front 26

What two factors increase the risk of hemolytic-uremic syndrome?

Back 26

High initial WBC; Antibiotic treatment (due to phage induction)

Front 27

EHEC/STEC (human specific or zoonoses)?

Back 27

Zoonoses (hamburger)

Front 28

EHEC/STEC (low infectious dose or high infectious dose)?

Back 28

LOW

Front 29

What bacteria may you get from unpasteurized apple cider and milk?

Back 29

EHEC/STEC (as well as salmonella)

Front 30

What type of AGAR would be useful if you wanted to grow E. COLI 157 H7?

Back 30

sorbitol MacConkey (O157 does not ferment sorbitol)

Front 31

BFP and virulence plasmid usefule for ID'ing what E. Coli?

Back 31

EPEC

Front 32

EAE probes are specific for what?

Back 32

Intimin (EPEC and/or EHEC)

Front 33

Does STEC have intimin?

Back 33

NO

Front 34

ETEC (secretory or inflammatory)?

Back 34

Secretory

Front 35

Attaching and Effacing Lesions in intestinal (which E. Coli)?

Back 35

EPEC and EHEC

Front 36

Invasion of epithelial cells, colonic ulcers, dysentery (EHEC, EPEC, EIEC, ETEC)?

Back 36

EIEC

Front 37

Inflammatory diarrhea, carried by new puppies, gull shaped rods?

Back 37

Campylobacter jejuni

Front 38

C. jejuni is microaerophilic T/F?

Back 38

TRUE;

Front 39

C. Jejuni (oxidase negative or positive)?

Back 39

Positive

Front 40

Campylobacter jejuni (human specific or zoonoses)?

Back 40

Zoonoses (birds and other amimals)

Front 41

What are the two major complications of campylobacter jejuni?

Back 41

Guillain Barre and Reiter's Syndrome

Front 42

What is the mechanism for Guillain Barre developed from campylobacter jejuni?

Back 42

antibody cross reacts with peripheral nerve myelin

Front 43

This syndrome complicates campylobacter jejuni and Shigella, causes a reactive arthritis, affects the urinary tract, eyes, skin and mucus membranes, and affects HLA b27 patients more?

Back 43

Reiter's Syndrome

Front 44

What do you need to culture campylobacter jejuni?

Back 44

selective medium WITH antibiotics, 42 degree C, Increased CO2, look for oxidase +

Front 45

Which vibrio cholera cause epidemic and pandemic cholera?

Back 45

O1 and O139

Front 46

Cholera (inflammatory or secretory diarrhea)?

Back 46

Secretory (watery, vomiting, leg crasmps)

Front 47

Which biotype of V. cholera is more severe (El Tor or Classical)?

Back 47

Classical

Front 48

What are some clinical signs of cholera gravis?

Back 48

rice water stool; absent peripheral pulse; decreased BP; sunken eyes; decreased turgor; hyperventilation; muscle cramps (decreased K)

Front 49

How does V cholera colonize the small intestine?

Back 49

Toxin co-regulated pili (TCP)

Front 50

The A subunit of cholera toxin does what?

Back 50

activates adenyalte cyclase via ADP ribosylation of the GTP-binding protein

Front 51

The B subunit of cholera binds to what?

Back 51

GM1 ganglioside molecules

Front 52

Where is the Cholera toxin encoded?

Back 52

bacteriophage

Front 53

Which virulence factor is most important for cholera (TCP or cholera toxin)?

Back 53

cholera toxin

Front 54

Cholera toxin increase Cl secretion in crypt cells T/F?

Back 54

TRUE;

Front 55

Cholera toxin causes decreased absorption of Cl and Na in villus cells T/F?

Back 55

TRUE;

Front 56

V. Cholera (low infectious dose, or high infectious dose)?

Back 56

HIGH (person to person not important)

Front 57

T/F seafood can transmit V. Cholera?

Back 57

TRUE

Front 58

T/F decreased acidity in the stomach (achloridia) will increase severity of Cholera?

Back 58

TRUE;

Front 59

What blood group increases the severity of cholera infection?

Back 59

O

Front 60

T/F V. Cholera can be transmitted through frozen fresh coconut milk?

Back 60

TRUE;

Front 61

What kind of AGAR should you use for V. Cholera?

Back 61

TCBS (sucrose fermenting)

Front 62

What kind of therapy is recommended for Cholera?

Back 62

Oral rehydration salts and Ringers lactate

Front 63

This bacteria produces a thermostable hemolysin (Tdh) previously called Kanagawa toxin?

Back 63

V. Parahaemolyticus

Front 64

Common in JAPAN, Seafood, watery diarrhea?

Back 64

V. Parahaemolyticus

Front 65

Raw Oysters?

Back 65

V. cholera, parahaemolyticus, vulnificus

Front 66

What happens to the incidence of V. parahaemolyticus as temperature increases ?

Back 66

Increases; something with oysters

Front 67

Exposure to contaminated sea water leading to wound infections?

Back 67

V. vulnificus