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31 Cards in this Set
- Front
- Back
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Bromocriptine & Cabergoline |
Dopa-Agonists used to treat Prolactionoma by inhibiting PRL release via Dopa |
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Somatropin |
Recombinant GH 1st line to trx Dwarfism |
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Mecasermin |
Recombinant IGF-1 to trx Dwarfism |
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Octreotide & Lanreotide |
Somatotopin Receptor Ligand (SRL) that inhibit the release of GH to trx Acromegaly |
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Pegvisomant |
GH antagonist to trx Acromegaly |
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Leuprolide & Goserelin |
GnRH agonists to trx prostate cancer by inducing negative feedback to decrease LH and FSH and thus decrease testosterone |
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Degarelix |
GnRH anatogonists to trx prostate cancer by decreasin LH and FSH |
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Phenoxybenzamine followed by a Beta-Blocker and surgery |
Trx of Pheochromocytoma (order important! -- if you give Beta-blocker before alpha, it can cause a HTN crisis) |
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Cortisone, Hydrocortisone, Prednisone |
Short-acting exogenous glucocorticoids that are the preferred trx for adrenal insufficiency in order to avoid iatrogenic Cushings |
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Ketaconazole & Metyrapone |
Steroid synthesis inhibitors given to trx ACTH-dependent Pituitary Adenomas following surgical resection |
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Fludrocortisone |
Mineralocorticoid replacement therapy for salt-wasting adrenal insufficiencies |
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Alendronate |
Bisphosphonate incorporated into bone matrix to inhibit FDS needed to tether membrane proteins causing Clasts apoptosis
*SE: Osteonecrosis of jaw, atypical femur fracture, GI ulcers, decreased absorption with meals |
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Denosumab |
Ab against RANKL to prevent blasts from stimulating clasts |
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Teriparatide (Forteo) |
Recombinant PTH that builds bone |
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Raloxifene |
SERM that decreases fractures and breast cancer risk |
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Levothyroxine |
T4 replacement for hypothyroidism trx |
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Liothronine |
T3 replacement for myxoedema coma hypothyroid pts in order to quickly raise active TH levels
*very narrow therapeutic range |
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Methimazole |
1st line for hyperthyroidism. Blocks TPO Can't use in 1st trimester pregnant (scalp lesions) May cause agranulocytosis |
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Propylthiouracil (PTU) |
2nd line for hyperthryoidism Blocks TPO Safe for pregnancy SE: Liver toxicity, agranulocytosis |
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I-131 |
Radioactive iodine for radioabation "cure" of hyperthyroidism or thyroid cancer |
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I-123 |
Iodine used in iodine uptake studies |
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Trx for Thyroid Strom |
1. High dose Iodide (wolf-chiakoff effect) 2. PTU 3. Propranolol 4. Glucocorticoid |
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Glipizide |
Sulfonurea that closes K+ channel to increase insulin release. DM2
*causes weight gain, not ok for sulfa allergy or renal pts |
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Repoglinide |
Meglitinide that closes K+ channel to increase insulin release in DM2
*weight gain |
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Exonatide |
GLP-1 agonists for DM2
*Increases insulin release from GI, prevents beta cell apoptosis, prevents glucagon release
*weight loss |
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Sitagliptin |
DPP-IV anatoginists that prevents GLP-1 breakdown in DM-2 |
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Intensive Basal Bolus Insulin Regime |
Lispro (short-acting) before meals Glargine (long, flat) before bed |
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Convential Insulin Regime |
NPH (Int - 6 hr peak, gone in 12hrs) before breakfast and dinner |
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Metformin |
1st line trx fro DM2
*decreases gluconeogenesis in DM2, weight loss, decrease in TG and FFAs |
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Pioglitazone |
Thiazolidinedione that activates PPARa to increase GLUT4 and thus increases Glucose uptake, deceases TG
*weight gain, not ok for CHF or liver pts |
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Canoglifozin |
SGLT-2 inhibitor to prevent Glucose reabsorption at prox tubule and thus increase its excretion
*SE: UTIs and yeast infectionw |
