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24 Cards in this Set
- Front
- Back
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the three components to LPS
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1. Lipid A (buried in OM)
2. Core polysaccharide 3. O specific Ant |
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part of LPS that varies with strain
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O antigen
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part of LPS which is conserved w/in species
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core polysaccharide
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cell wall is made out of
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peptoglycan
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cell wall of gram positives has what acid has what
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teichoic acids
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what part of LPS is recognized on PCR
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lipid A (it is a PAMP)
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what cytokine is the most important in inducing endotoxin shock
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TNF
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steps in DIC
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lipid A - Factor XII - Thrombin - Fibrin - Clotting - Depletion of Platelets - Clot dissolves - local bleeding (purpura)
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why is laboratory detection of bacteria and septecemmia different
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in bacteria - bacteria is transient
in septecemia - blood acts as a site of replication and transfer |
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Horse shoe Cra agglutinate test is very sensitive and detects what part of LPS
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Lipid A
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how does LPS cause endotoxic shock
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LBP binds LPS
LBP-LPS binds SCD14 (delivers LPS to CD14) LPSmCD14 bind TLR4/MD-2 Rece release of TNF, IL1,6,9 innate response, inflammation, activates acquired immunmity, mediator synthesis |
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what inhibirs mediator synthesis in endotoxic shock
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Prostaglandin E2
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three main symptoms of endotoxic shock
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1. Fever, Hypotension, Fibrinolysis
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two things that lead to hypotension in endotoxic shock
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No
Bradykinin |
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endotoxin vs. exotoxin
denatured by boiling? Antigenic Forms Toxoid |
endotoxin is not denatured by boiling, exotoxin is
both are antigenic only exotoxin can form toxoid |
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High or low potency
endotoxin vs. exotoxin |
exotoxin has high Potency AND Speficity
endotoxin has low potency and spcificity |
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endotoxin vs. exotoxin
enzymatic activity? |
exotoxin yes
endotoxin no |
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fever inducing
endtotoxin vs exotoxin |
yes endotoxin, sometimes exotoxin does
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two purposes of the O antigen
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1. variable surface (protection)
2. permeability barrier |
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can Gram cause endotoxin response
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no exactly but CM can cause similar response when lysed
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is endotoxin secreted
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no - released when cell lysed
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what accounts fore the variability in outcome due to endotoxic shock
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the polysaccharide O antigen influences the activity of lipid A
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The TWO strongest mediators fo toxic shock
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TNF and IL-1
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the two consequences of DIC
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localized necrosis
generalized bleeding |
