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9 Cards in this Set
- Front
- Back
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pain
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pgf2alpha
pge2 NGF |
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What does PGF2alpha do?
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- vasoconstrictor involved in uterine contractions
- dysmennorrhea & abnorma contractions during menstruation |
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pge2
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- produced by inflammatory cells & endometriotic stromal cells
- activates nerve fibres causing pain - promotes estrogen biosynthesis |
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NGF
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- promotes growth sensory, sympathetic and parasympathetic nerves
- present in eutopic endometrium of women with endometriosis but not normal women - unmyelinated c fibres found exclusively in functionalis of women with endometriosis |
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mechanisms leading to infertility
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- inflammatory products are toxic to gametes and embryos
- fibriae malfunction to due to fibrosis - dysregulated progesterone regulated genes in endometrial stroma prevents implantation |
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epigenetic effects on gene function
endometric lesions |
- less than normally methylated increasing expression levels compared to endometrium e.g. ERalpha.
- micro RNAs are altered |
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epigenetic effects on gene function
eutopic endometrium |
- several genes involved in implantation are HYPERMETHYLATED
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epigenetic effects on gene function
endometriosis |
DNA methyl transferases are upregulated suggesting a widespread genome methylation
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Why do some women develop endometriosis?
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GENETIC PREDISPOSITION
genes involved in endometrial development estrogen receptor-a regulation epithelial cell adhesion |
