Endocrine/repro Drugs

Front 1

Leuprolide

Back 1

GnRH analog. with agonist and antagonist properties depending if its pulsatile or not.

"Leuprolide can be used in lieu of GnRH

Front 2

Finastride

Back 2

5 alpha reductase inhibitor (decrease conversion of testosterone to dihydrotestosterone). Usefull in BPH. Also promotes hair growth.

Finastide will cause a man to go from bald to lookin fine

Front 3

tx for polycystic ovarian syndrome?

Back 3

Ketoconazole, Spironolactone

Front 4

Flutamide

Back 4

nonsteroidal competitive inhibitor of angrogens at the testosterone receptor. Used in prostate carcinoma

"A man with become a fruit w/ flutamide (blocks testosterone receptors"

Front 5

Clomiphene

Back 5

Partial agonist at estrogen receptors in hypothalamus. Prevents feedback inhibition increasing LH and FSH --> stimulates ovulation.
-Used in infertility PCOS,
-May cause hot flashes, ovarian enlargement, increase pregnancies, and visual problem

"Clommering children running phree bc you were given clomiphene which turned you into the octa-mom"

Front 6

Tamoxifen

Back 6

-Agonist on breast tissue; used to treat and prevent recurrence of ER-positive breast cancer
-increases risk of breast cancer

"Tamoxifen is used for women (they use TAMpons) who have breast cancer"

Front 7

Ralfoxifene

Back 7

Agonist on bone; reduces resorption of bone; used to treat osteoporosis

"Ralf was a big boned woman"

Front 8

Aromatase inhibitors used in postmenopausal women with breast cancer

Back 8

Anastrozole / exemestane

ANA STruddle, his EX was a MES but she didn't have breast cancer!

Front 9

Mifepristone (RU-486)

Back 9

-Competitve inhibitor of progestins at progesterone receptors
-Termination of pregnancy. Administered with misoprostol (PGE1)
-also a glucocorticoid agonist, used in cushings
-side effects: heavy bleeding, GI, abdominal pain

"She was MIs PRISTINe so she couldn't have the baby. She had to get an abortion"

Front 10

Dinoprostone

Back 10

PGE2 analog causing cervical dilation and uterine contractions, inducing labor

"Dinoprostone will help you in labor even if your giving birth to a DINOsaur.

Front 11

B2 agonists that relax the uterus and reduce premature uterine contractions

Back 11

Ritodrine and Terbutaline

"Ritodrine allows the fetus to return to dreams" (its also wearing a turbin)

Front 12

Tamsulosin

Back 12

-alpha1 antagonist used to treat BPH by inhibiting smooth m. contraction.
-TAM, the SULton's Alpha 1 SON had BPH"

Front 13

short-acting insulin drugs

Back 13

-Lispro, aspart, regular insulin

"Lispo was a spartan and was Fast"

Front 14

intermediate-acting insulin drug?

Back 14

NPH

Front 15

long acting insulin drugs?

Back 15

Glargine and Detemir

DETErmined to get there even if it takes forever in the GLARing sun

Front 16

Action of insulin drugs?

Back 16

Bind insulin reseptor (tyrosine kinase activity)
Liver: increase glucose stored as glyogen
Muscle: increase glycogen and protein synthesis, K+ uptake
Fat: aids TG storage

Front 17

Clinical use of insulin drugs?

Back 17

type 1 DM and type 2 DM

Also life-threatening hyperkalemia and stress-induced hyperglycemia

Front 18

toxicities of insulin drugs?

Back 18

Hypoglycemia, hypersensitivity reaction (very rare)

Front 19

First generation sulfonylureas and toxicity?

Back 19

Tolfbutamide and Chlorpropamide

I first Told you there was Chlorine in the drink! Now you'll have a disulfiram-like reaction

Front 20

second generation sulfonylureas and toxicities?

Back 20

Glyburide, Glimepiride, Glipizide

all start with G "grade 2" hypoGlycemia

Front 21

action of sulfonylureas?

Back 21

Close k+ channel in B-cell membrane so cell depolarizes --> triggering of insulin release via increased calcium influx

"The number of diabetic Cali residents increase even tho it smells like sulfur"

Front 22

Clinical use of sulfonylureas?

Back 22

stimulate release of endogenous insulin in type 2 DM

Front 23

Biguanides and toxicity?

Back 23

-Metformin
-Lactic acidosis (C/I in renal failure)
"I met a foramen that sold milk"

Front 24

Bequanides

Back 24

-insulin sensitizer
-Used as oral hypoglycemic
-DM1 and DM2

Front 25

Glitazones/thiazolodinediones and toxicity?

Back 25

Pioglitazone
Rosiglitazone

Weight gain, edema, Hepatotoxiity, CV toxicity

A sensitive (increase sensitivity) fat girl rubbing her "glit" and drinking. Shes overweight so she has heart problems

Front 26

Glitazones/thiazolodinediones mechanism and clinical use?

Back 26

-increase insulin sensitvity
-Used as monotherapy in type 2 DM or combined

Front 27

alpha-glucosidase inhibitors and toxicity?

Back 27

Acarbose
Miglitol
GI disturbances
"My girl is eats carbs and throw them up"

Front 28

alpha-glucosidase inhibitor mechanism and clinical use?

Back 28

-Inhibit intestinal brush border alpha-glucosidases
-Delayed sugar hydrolysis and glucose absorption lead to decrease postpandial hyperglycemia
-monotherapy in DM 2

Front 29

Insulin mimetic

Back 29

pramlintide
decreases glucagon
DM 2
causes hypoglycemia, N/V

Front 30

GLP-1 mimetic

Back 30

-exenatide
-increase insulin, decrease glucagon release
-used in DM 2
-N/V pancreatitis

Front 31

Orlistat

Back 31

-Alters fat metabolism by inhibiting pancreatic lipases
-Long term obesity management
-toxicity: Steatorrhea, GI, decreased absorption of fat-soluble vitamins, headache

"otliSTAT gets rid of FAT"

Front 32

Sibutamine

Back 32

-Sympathomimetic serotonin and NE reuptake inhibitor
-Short term and long term obesity management
-Toxicity: hypertension and tachycardia

Sibastian wanted to get rid of his fat so he increased his BP and HR

Front 33

Propylthiouracil, methimazole

Back 33

-Inhibit organification of iodide and coupling of thyroid hormone synthesis. Propylthiouracil also decreases peripheral conversion of T4 to T3
-Use for hyperthyroidism
-Toxicity= rash, agranuloctosis and aplastic anemia

If you have hyperthyroidism... you're PROPbably on METH

Front 34

Levothyroxine, triiodothyronine

Back 34

-Thyroxine replacement
-use for hypothyroidism, myxedema
-toxicity: tachycardia, heat intolerance, tremors, arrythmias (symptoms of hyperthyroidism)

Front 35

Somatostatin (octreotide) is used to tx what disorders?

Back 35

-Acromegaly
-carcinoid
-gastrinomas
-gluconoma

Front 36

Demeclocycline

Back 36

-ADH antagonist (member of the tetracycline family)
-use for SIADH
-toxicity: Nephrogenic DI, photosensitivity, abnormalities of bones and teeth

Front 37

Misoprostol

Back 37

-Misoprostol is a prostaglandin analog (PGE1) that protects the gastric lining by increasing mucous secretion.