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17 Cards in this Set

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Q: What are the (3) classes of Insulin Secretagogues

A: Insulin Secretagogues
Q: The below are all subtypes of what drug class?

A:
(1) Sulfonylureas
(2)Meglitinides
(3) incretin based therapies
(exenatide, DPP-4 inhibitors)
Q: What is the (1) Biguanide commonly prescribed?

A: Biguanide
Q: Metformin is which class of drug?

A: Metformin
Q: What (2) drugs studied in this class are insulin sensitizers?

A: Insulin Sensitizers
Q: The 2 drugs below belong to which class of drugs?

A: The GLITAZONES
(1) rosiglitazone (2) pioglitazone
Q: Name (2) alpha-glucosidase inhibitors

A: Diabetes - Alpha-glucosidase inhibitors
Q: The below drugs are used to treat what disease, and belong to which class?

A: (1) acarbose (2) miglitol
Q: Which anti-diabetic drug is an amylinmimetic?

A: Amylinmimetic
Q: The below drug belongs to which class?

A: Pramlintide
Q: Name the (5) sulfonylureas.

A: Work by binding to a receptor and causing closure of the K channel in beta cells > leading to depolarization and calcium influx > which is followed by nutrient independent INSULIN RELEASE
Q: What is the mechanism of action of the drugs below?

A: (1) Tolbutamide and (2) Chlorpropamide in deveoping countries. (3) Glyburide, (4) Glipizide, and (5) Glimipride in the U.S.
Q: What are the risks associated with sulfonylureas?
Q:
A:
1. hypOglycemia
2. weight gain
3. fairly high failure rate (1/3 never respond, and another 10% fail every year)
Q: Define the term below:

A: Insulin Secretagogue
Q: What fits the definition below:

A: A substance that causes the secretion of insulin.
Q: Define the Mechanisms of Meglitinides (Repaglinide and Nateglinide).

A. Meglitinides (repaglinide & nateglinide)
Q: Which 2 drugs work by the mechanism described below?

A: Bind to the SU receptor on beta cells, causing closure of K channel, depolarization of cell, influx of calcium, and release of insulin. QUICK ONSET AND SHORT ACTING. Lowering risk of hypoglycemia and and safe with renal insufficiency.
Q: This subset of of insulin secretagogues must be given with each meal.

A: They share the same mechanism of action but are faster acting and shorter duration.
Q: How do meglinitides differ from Sulfonylureas?

A: Meglitinides
Q: This class of drugs mimic the natural stimulation of insulin secretion after meals (which is usually glucose dependent).

A: They bind to cell surface receptors on alpha cells, leading to increased insulin secretion, decreased glucagon secretion, secretion, delayed gastric emptying, and stimulation of beta cell growth.
Q: How does the below class of drugs actually work?

A: The Incretins (GLP-! agonists like Exenatide)
Q: Why is oral glucose more effective than IV glucose?
A: Incretins (GLP-1 and GIP)
Why would you use dopamine agonists?
To inhibit PRL secretion. They can actually lead to regression of a pituitary tumor without surgery. ***they can somteimes also effectively inhibit GH producing tumors***
Why would you use somatostatin analogs?
To inhibit GH secretion.
How might you inhibit GH?
1. Somatostatin analog
2. GHR antagonist
3. PIF (dopamine) agonists
these drugs do what?

ketokonazole,
op'-DDD,
aminoluttethimide
block cortisol synthesis
What is the mode of actiuon of RU486?
blocks GC action

(also used for abortions)