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17 Cards in this Set
- Front
- Back
Q: What are the (3) classes of Insulin Secretagogues
A: Insulin Secretagogues |
Q: The below are all subtypes of what drug class?
A: (1) Sulfonylureas (2)Meglitinides (3) incretin based therapies (exenatide, DPP-4 inhibitors) |
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Q: What is the (1) Biguanide commonly prescribed?
A: Biguanide |
Q: Metformin is which class of drug?
A: Metformin |
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Q: What (2) drugs studied in this class are insulin sensitizers?
A: Insulin Sensitizers |
Q: The 2 drugs below belong to which class of drugs?
A: The GLITAZONES (1) rosiglitazone (2) pioglitazone |
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Q: Name (2) alpha-glucosidase inhibitors
A: Diabetes - Alpha-glucosidase inhibitors |
Q: The below drugs are used to treat what disease, and belong to which class?
A: (1) acarbose (2) miglitol |
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Q: Which anti-diabetic drug is an amylinmimetic?
A: Amylinmimetic |
Q: The below drug belongs to which class?
A: Pramlintide |
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Q: Name the (5) sulfonylureas.
A: Work by binding to a receptor and causing closure of the K channel in beta cells > leading to depolarization and calcium influx > which is followed by nutrient independent INSULIN RELEASE |
Q: What is the mechanism of action of the drugs below?
A: (1) Tolbutamide and (2) Chlorpropamide in deveoping countries. (3) Glyburide, (4) Glipizide, and (5) Glimipride in the U.S. |
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Q: What are the risks associated with sulfonylureas?
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Q:
A: 1. hypOglycemia 2. weight gain 3. fairly high failure rate (1/3 never respond, and another 10% fail every year) |
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Q: Define the term below:
A: Insulin Secretagogue |
Q: What fits the definition below:
A: A substance that causes the secretion of insulin. |
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Q: Define the Mechanisms of Meglitinides (Repaglinide and Nateglinide).
A. Meglitinides (repaglinide & nateglinide) |
Q: Which 2 drugs work by the mechanism described below?
A: Bind to the SU receptor on beta cells, causing closure of K channel, depolarization of cell, influx of calcium, and release of insulin. QUICK ONSET AND SHORT ACTING. Lowering risk of hypoglycemia and and safe with renal insufficiency. |
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Q: This subset of of insulin secretagogues must be given with each meal.
A: They share the same mechanism of action but are faster acting and shorter duration. |
Q: How do meglinitides differ from Sulfonylureas?
A: Meglitinides |
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Q: This class of drugs mimic the natural stimulation of insulin secretion after meals (which is usually glucose dependent).
A: They bind to cell surface receptors on alpha cells, leading to increased insulin secretion, decreased glucagon secretion, secretion, delayed gastric emptying, and stimulation of beta cell growth. |
Q: How does the below class of drugs actually work?
A: The Incretins (GLP-! agonists like Exenatide) |
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Q: Why is oral glucose more effective than IV glucose?
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A: Incretins (GLP-1 and GIP)
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Why would you use dopamine agonists?
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To inhibit PRL secretion. They can actually lead to regression of a pituitary tumor without surgery. ***they can somteimes also effectively inhibit GH producing tumors***
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Why would you use somatostatin analogs?
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To inhibit GH secretion.
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How might you inhibit GH?
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1. Somatostatin analog
2. GHR antagonist 3. PIF (dopamine) agonists |
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these drugs do what?
ketokonazole, op'-DDD, aminoluttethimide |
block cortisol synthesis
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What is the mode of actiuon of RU486?
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blocks GC action
(also used for abortions) |