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84 Cards in this Set
- Front
- Back
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Lispro
mech |
short-acting insulin
tyrosine kinase activity glycogen syn in liver glycogen and protein syn in muscle K uptake in m. fat storage in fat |
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Lispro
use |
type 1 and 2 dm
life-threaten hyperkalemia stress caused hyperglycemia |
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Insulin analog
SE |
rare hypersensitivity
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Aspart
mech |
short-acting insulin
tyrosine kinase activity glycogen syn in liver glycogen and protein syn in muscle K uptake in m. fat storage in fat |
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Aspart
use |
DM
hyperkalemia (life) hyperglycemia (stress) |
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NPH
mech |
intermediate acting
tyrosine kinase activity glycogen syn in liver glycogen and protein syn in muscle K uptake in m. fat storage in fat |
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NPH
use |
DM
hyperkalemia hyperglycemia (stress) |
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Glargine
mech |
long acting insulin
tyrosine kinase activity glycogen syn in liver glycogen and protein syn in muscle K uptake in m. fat storage in fat |
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Glargine
use |
DM
hyperglycemia and hyperkalemia |
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Detemir
mech |
long-acting insulin
tyrosine kinase activity glycogen syn in liver glycogen and protein syn in muscle K uptake in m. fat storage in fat |
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Tolbutamide
mech |
first generation
sulfonylurea closes K channel depolarizes cell increased Ca insulin released |
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Tolbutamide
uses |
Type 2 DM
not type 1 b/c no beta cells |
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Tolbutamide
SE |
disulfarim-like se
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Chlorpropamide
mech |
1st generation sulfonylurea
close K channel depolarize increase Ca triggers insulin release |
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chlorpropamide
use |
type 2 dm
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chlorpropamide
se |
disulfiram-like se
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Glyburide
mech |
2nd generation sulfonylurea
k channel closes depolarize increase Ca triggers insulin release |
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Glyburide
use |
type 2 dm
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glimepiride
mech |
2nd generation
sulfonylurea closes K channel depolarizes cell increased Ca insulin released |
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glimepiride
use |
type 2 dm
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glipizide
mech |
2nd generation
sulfonylurea closes K channel depolarizes cell increased Ca insulin released |
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glipizide
use |
type 2 dm
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metformin
mech |
unknown
decrease gluconeogenesis increase glycolysis decrease serum glucose insulin sensitizer |
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metformin
use |
dm type 1 and 2
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metformin
se |
lactic acidosis
contraindicated: renal failure |
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pioglitazone
mech |
increase insulin sensitivity in periphery
|
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pioglitazone
use |
type 2 dm
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pioglitazone
se |
weight gain
edema hepatotoxicity cv toxicity |
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rosiglitazone
mech |
increase insulin sensitivity in peripheral tissue
|
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rosiglitazone
use |
type 2 dm
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rosiglitazone
use |
type 2 dm
|
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rosiglitazone
se |
weight gain
edema hepatotoxicity cv toxicity |
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acarbose
mech |
alpha-glucosidase inhibitor in gut brush border
sugar not hydrolyzed/glucose not absorbed decrease postprandial hyperglycemia |
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acarbose
use |
type 2 dm
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acarbose
se |
gi probs
|
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miglitol
mech |
alpha-glucosidase inhibitor at gut brush border
sugar not hydrolyzed and glucose not absorbed decrease postprandial hyperglycemia |
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miglitol
use |
type 2 dm
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miglitol
se |
gi probs
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pramlintide
mech |
decrease glucagon
|
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pramlintide
use |
type 2 dm
|
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pramlintide
se |
hypoglycemia
nausea diarrhea |
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exenatide
mech |
GLP-1 mimetic
increase insulin decrease glucagon |
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exenatide
use |
type 2 dm
|
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exenatide
se |
n/v
pancreatitis |
|
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orlistat
mech |
inhibit pancreatic lipase
"orlistat gets rid of fat" |
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orlistat
use |
obseity
|
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orlistat
se |
steatorrhea
reduced absorption of fat-sol vitamins headache |
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sibutramine
mech |
sympathomimetic serotonin and NE reuptake inhibitor
|
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sibutramine
use |
obesity
|
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sibutramine
se |
hypertension
tachycardia |
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sibutramine
se |
hypertension
tachycardia |
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propylthioruacil
mech |
inhibit organification of iodide I- -> I2
inhibit coupling of TH synthesis decrease T4 -> T3 peripheral conversion |
|
|
propylthiouracil
use |
hyperthyroidism
|
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propylthiouracil
se |
skin rash
agranulocytosis rare aplastic anemia |
|
|
methimazole
mech |
inhibit organifiction of iodide
inhibit coupling of TH synthesis decrease T4 to T3 peripheral conversion |
|
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methimazole
use |
hyperthryoidism
|
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methimazole
se |
skin rash
agranulocytosis aplastic anemia |
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levothyroxine
mech |
thyroxine replacement
|
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levothyroxine
use |
hypothyroidism
myxedema |
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levolthyroxine
se |
tachycardia
tremor arrythmia |
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triidothyronine
mech |
thyroxine replacement
|
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triidothyronine
use |
hypothyroidism
myxedema |
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thriidothyrodine
se |
tachycardia
tremor arrythmia |
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GH
use |
GH hormone deficiency
turner's syndrome |
|
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somatostatin - octeotride
use |
acromegaly
carcinoid gastrinoma glucagonoma |
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oxytocin
use |
stimulate labor
milk let-down uterine hemmorhage |
|
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ADH - desmopressin
use |
pituitary diabetes insipidus (central not nephrogenic)
|
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Demeclocycline
mech |
tricycline
ADH antagonist |
|
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Demeclocycline
use |
SIADH
|
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Demeclocycline
se |
nephrogenic DI
bone/teeth abnormality photosensitivity |
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hydrocortisone
mech |
decrease leukotriene and prostaglandin by
inhibit phospholipase A2 and COX2 expression |
|
|
hydrocortisone
use |
addison's dz
inflammation/immune suppression asthma |
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hydrocortisone
se |
cushings syndrome
|
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prednisone
mech |
inhibit phospholipase a2 and cox2
decreases leukotriene and prostaglandins |
|
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prednisone
use |
addison's dz
inflammation/immune suppression asthma |
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prednisone
se |
cushings syndrome
|
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triamcinolone
mech |
inhibit phospholipase a2 and cox2
decrease leukotriene and pgs |
|
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triamcinolone
use |
addisons dz
inflam/immune suppression asthma |
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dexamethasone
mech |
inhibit phospholipase a2 and cox 2
decrease leukotriene and prostaglandin production |
|
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dexamethasone
use |
addisons dz
inflammation immune suppression asthma |
|
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dexamethasone
se |
cushings
|
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beclomethasone
mech |
inhibit phospholip a2 and cox2
decrease leukotriene and prostaglandin production |
|
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beclomethasone
use |
addisons dz
inflammation immune suppression asthma |
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beclomethasone
se |
cushings
|
