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13 Cards in this Set
- Front
- Back
Is testosterone effective when administered orally?
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no- inactivated by first-pass metabolism in liver
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What enzyme converts testosterone to DHT
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5-α-reductase
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Where is 5-α-reductase found?
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Skin, epididymis, prostate, seminal vesicles
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What drug inhibits 5-α-reductase?
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Finasteride
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What are the two main therapeutic indications of finasteride?
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Benign Prostatic Hyperplasia and male pattern baldness
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Why is finasteride contraindicated in pregnancy?
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Abnormalities of external male genitalia
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What are the uses of tesosterone and its derivatives (danazol, stanozol, nandrolone, oxandrolone)?
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Male hypogonadism, increase muscle mass, increase RBCs, decrease nitrogen excretion, endometriosis
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What are the adverse effects of testosterone?
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Edema, premature closing of the epiphysis, increased aggression, psychosis, increased LDL, decreased HDL, cholestatic jaundice, decreased spermatogenesis, gynecomastia, increased masculinization
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What drug inhibits the synthesis of androgens and is also used as a diuretic?
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Spironolactone
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What drug inhibits the synthesis of androgens and is also used as an antifungal?
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Ketoconazole
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What drug acts as androgen receptor blockers and are used in the treatment of prostate cancer?
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Flutamide, bicalutamide
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What is the MOA of leuprolide?
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GnRH agonist (daily administration suppresses LH and FSH secretion thereby inhibiting ovarian and testicular steroidogenesis)
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What are the therapeutic uses of leuprolide?
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Prostate cancer, endometriosis
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