• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/13

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

13 Cards in this Set

  • Front
  • Back
Is testosterone effective when administered orally?
no- inactivated by first-pass metabolism in liver
What enzyme converts testosterone to DHT
5-α-reductase
Where is 5-α-reductase found?
Skin, epididymis, prostate, seminal vesicles
What drug inhibits 5-α-reductase?
Finasteride
What are the two main therapeutic indications of finasteride?
Benign Prostatic Hyperplasia and male pattern baldness
Why is finasteride contraindicated in pregnancy?
Abnormalities of external male genitalia
What are the uses of tesosterone and its derivatives (danazol, stanozol, nandrolone, oxandrolone)?
Male hypogonadism, increase muscle mass, increase RBCs, decrease nitrogen excretion, endometriosis
What are the adverse effects of testosterone?
Edema, premature closing of the epiphysis, increased aggression, psychosis, increased LDL, decreased HDL, cholestatic jaundice, decreased spermatogenesis, gynecomastia, increased masculinization
What drug inhibits the synthesis of androgens and is also used as a diuretic?
Spironolactone
What drug inhibits the synthesis of androgens and is also used as an antifungal?
Ketoconazole
What drug acts as androgen receptor blockers and are used in the treatment of prostate cancer?
Flutamide, bicalutamide
What is the MOA of leuprolide?
GnRH agonist (daily administration suppresses LH and FSH secretion thereby inhibiting ovarian and testicular steroidogenesis)
What are the therapeutic uses of leuprolide?
Prostate cancer, endometriosis