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10 Cards in this Set
- Front
- Back
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embryological origin of adrenal cortex
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mesenchyme
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zones, secreted products, what stimulates layers of mesenchyme of adrenal gland
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zona glomerulosa: mineralocorticoids (aldosterone)
stim by angiotensin zona fasciculata: glucocorticoids (cortisol) stim by ACTH zona reticularis sex steroids ACTH stimulation |
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embryological origin of neural crest
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neural crest
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blood supply of adrenal glands
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renal and inferior phrenic arteries
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massive hemorrhage of adrenocortex secondary to bacterial infection (what bug?)
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waterhouse-friderich syndrome, neisseria meningitidis
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cause of addison's disease (primary chronic adrenocortical hypofunction)
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usually autoimmune, assoc with antibodies to adrenal cortex and other endocrine tissues (white women)
sometimes granulomatous disease, amyloid, neoplasm (lung, breast) |
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signs and symptoms of addissons, what hormones decreased and effects
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weakness fatigability anorexia nausea vomiting weight loss and diarrhea
1 dec mineralocorticoids: HYPONATREMIA HYPOTENSION VOLUME DEPLETION 2 dec glucocorticoids: HYPOGLYCEMIA 3 decreased urinary steroids 4 increased ACTH ann increased ACTH precursor: HYPERPIGMENTATION |
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difference between primary and secondary adrenocortical insufficiency
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NO hyperpigmentation (melanotropic hormone low)
NO hyponatremia NO hyperkalemia decreased glucocorticoids and androgens, normal aldosterone (angiotensin system) |
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most common adrenocortical hyperfunction disease
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cushing's syndrome
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cushing's syndrome pathogeneses
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usually iatrogenic from glucocorticoids
cushing's disease ACTH pituitary adenoma |
