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52 Cards in this Set
- Front
- Back
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What drug causes Prolactinoma?
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Haloperidol (Haldol)
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What causes prolactinoma?
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decrease in dopa
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Tx of prolactinoma?
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Bromocriptine
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What is the S/E of Levodopa?
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psychoses, hallucinations, hypotension, dyskinesia
go crazy w/ DOPA INCREASED! |
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What is bromocriptine? Acts on?
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Dopamine Agonist D2 receptor agonist
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What drug enhances levodopa effects?
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Tolcapone and Entacapone
Alcopone Protects levodopa |
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WHat is the effect of Tolcapone and Entacapone?
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AAAD inhibited
more dopa is converted by COMPT to 3-o-methyldopa also inhibit peripheral COMT to prevent L-dopa degradation |
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What is the A/E of tolcapone?
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Hepatotoxic
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DOPA low dose? what are the effects?
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alpha and beta agonist
adrenergic receptors activated lower dose activates B1 cardiac receptors activated increase heart rate |
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What are the effects of DOPA at high dose?
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Vasoconstriction by activating alpha receptors
D1 + D2 Renal = Vasodilation |
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Patient post-surgery w/ high fever Tx?
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Dantrolene'
pat. w/ malignant hyperthermia |
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Neuroleptic Malignant Syndrome is tx with?
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Dantrolene and Bromocriptine (DA agonist)
BOTH!!! |
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Agranulositosis pat?
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caused by Carba, Colchicine, and Clozapine
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What are the antipyschotics?
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haloperidol
chlorpromazine thioridazine fluphenazine |
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What are the atypical antipsychotics?
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Clozapine
Risepridone Olanzapine Ola says the Clown and risas... |
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Toxicity of Antipsychotics?
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OD w/ M block, alpha block
sedation decrease in seizure threshold |
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Antipsychotic that causes Tosade?
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Thioridazine
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A/E of Thioridazine?
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Cardiotoxic (torsade)
retinal deposits M block Alpha Block |
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A/E of chlorpromazine?
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ocular dysfunction
M block Alpha Block |
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What two antipsychotic cause EPS? (extra pyramidal symptoms)?
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Haloperidol
Fluphenazine |
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New antipsychotic that works on both D2 receptor agonist and blocks 5HT2 receptors?
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Ari piprazole
almost no side effects no EPS, no M block, no alpha block no sedation |
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What are the antipsychotics that cause the most sedation?
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Chlorpromazine
Thioridazine |
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What is tardive dyskinesia?
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Choreoathethetoid muscle movements
dance like and snake like movements mostly the typical antipsychotics cause this |
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DOC for Tourette Sx? or Huntington's Dz
Coprolalia |
Pimozide
Antipsychotic |
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What is promethazine used for?
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Preoperative sedation
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Drug/Radiation Emesis prevention?
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Prochlorperazine
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What gene is Rb gene found?
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chromos. 13
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What pathology is seen in Rb?
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Retinoblastoma
Osteosarcoma add the letters/2=13 |
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What is the mechanism of action of dantrolene?
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acts on the sarcoplasmic reticulum, prevents Ca+ release
muscle antispasmodic |
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What chromosome contains BRCA1 & 2?
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17q, 13q-
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What does BRCA cause?
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Breast and ovarian CA
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What chromosome contains p53?
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17q
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What chromosome contains p16?
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9p
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What disease is caused by p16 gene?
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Melanoma
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What chromosome is gene APC located?
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5p
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What does APC gene code for?
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Colorectal CA
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What chromosome is WT-1 located in?
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11q
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What does WT-1 gene cause?
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Wilm's Tumor
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What gchromo is NF-1 gene located in?
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17q
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What cancer is caused by NF-1 gene?
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Neurofibromatosis 1
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What chromo is NF-2 gene located in?
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22q
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What chromo. is DPC located in?
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18q
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What does DPC cause?
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pancreatic CA
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What chromo. is DCC?
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18q
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What does DCC predispose to?
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Colon CA
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When do you see Psammoma bodies?
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PSaMMoma
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When do you see Psammoma bodies?
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Papillary (thyroid) Serous (ovary, Meningioma, Mesothelioma
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Squamous cell CA produced by?
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Sun Exposure
Arsenic |
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Squamous Lung Cell Ca secrete?
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Hypercalcemia?
Calcium Stone Formers PTH-like peptide |
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PTH-like related peptide causing hypecalcemia?
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Squamous Cell Lung CA
Renal Cell CA Breast CA Multiple Myeloma Bone Metastasis |
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Renal Cell CA
Hemangioblastoma produce? |
Erythropoietin
Polycythemia |
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Thymoma
Small Cell Lung CA produce what exogenously? |
causes Ab to presynaptic Ca+ at neuromuscular junction
Lambert-Eaton Sx |
