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24 Cards in this Set
- Front
- Back
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too much bone resorption -->
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osteitis fibrosa cystica
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defects in bone matrix formation -->
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osteogenesis imperfecta
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defects in mineralization of bone matrix -->
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osteomalacia and rickets
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what leads to osteitis fibrosa?
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1' or 2' hyperparathyroidism
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what characterizes osteitis fibrosa?
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hypercalcemia, hypohosphatemia, hypercalciuria
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excess of osteoblasts and osteoclasts -->
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Paget's disease of bone
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What is the calcium in Paget's disease?
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normal
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Inherited defects in collagen gene leading to fractures and weak bones -->
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osteogenesis imperfecta
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what characterizes rickets (osteomalacia)?
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vit D def, phosphate def, or both
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what is the T-score range for osteopenia?
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(-2.5,-1]
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what is the T-score range for osteoporosis?
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(-infinity, -2.5]
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what is required for optimal absorption of calcium?
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adequate levels of Vitamin D (probably best at upper end of normal)
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What are some endocrine abnormalities that can cause osteoporosis?
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hyperparathyroidism
Cushing's syndrome Hyperthyroidism Hypogonadism Hyperprolactinemia |
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What are some GI problems that lead to osteoporosis?
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Gastrectomy
Malabsorption PBC |
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What are some malignancies that lead to osteoporosis?
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Myeloma
Leukemia Lymphoma Mastocytosis |
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What are some genetic dz that lead to osteoporosis?
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Osteogenesis imperfecta
Ehlers-Danlos ... |
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Treat or not: Postmenopausal women and men over 50 w/ prior vertebral or hip fracture
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treat
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Where does tamoxifen act?
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anti-estrogen: on E2 receptors in breast
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Where does Raloxifene act?
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pro-estrogen: Bone, serum lipids
anti-estrogen: Breast cancer |
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How do bisphosphonates work?
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inhibit osteoclast action
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Give some examples of bisphosphonates
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Etidronate
Pamidronate Alendronate Risedronate Ibandronate Zoledronic acid (1/yr injection) |
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how does calcitonin work?
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binds to and reduces activity/number of osteoclasts
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Name some RANK ligand inhibitors
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Osteoprotegerin
Denosumab |
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What is Teriparatide (PTH1-34)?
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anabolic agent that promotes new bone formation --> stimulates osteoblasts at low dose
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