Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
17 Cards in this Set
- Front
- Back
|
What is the most common cause of Cushing Syndrome?
|
iatrogenic administration of exogenous corticosteroids
|
|
|
What do glucocorticoids do to the body?
|
regulates metabolism and increases blood glucose and is critical to physiologic stress response
|
|
|
What do mineralocorticoids regulate?
|
Na+ and K+ balance
|
|
|
Androgen contributes to...
|
growth and development in both genders and sexual activity in adult women.
|
|
|
ACTH-secreting pituitary tumor is responsible for ___% of endogenous cases
|
85%
|
|
|
Other causes of Cushing Syndrome include...
|
adrenal tumors
Ectopic ACTH production in tumors outside hypothalamic-pituitary-adrenal axis (usually lung and pancreas tumors) |
|
|
What are the clinical manifestations of Cushing?
|
weight gain, hyperglycemia, protein wasting, loss of collagen (thin skin), delayed wound healing (d/t protein wasting), mood disturbances, insomnia, irrationality, psychosis, HTN, acne, virilization, feminization, striae on abd, buttocks, breasts.
|
|
|
What are the diagnostic studies for Cushing?
|
24-hr urine for free cortisol. If levels are 5-100 mcg/day, indicates Cushing.
High dose dexamethasone suppression test used for borderline results of 24hr urine cortisol. False + can occur with depression, EtOH, stress. Plasma cortisol lvls may be elevated with loss of diurnal variation. CT and MRI of pituitary and adrenal glands. |
|
|
What are associated findings that are not diagnostic of Cushing Syndrome?
|
leukocytosis
lymphopenia eosinopenia hyperglycemia glycosuria hypercalciuria osteoporosis |
|
|
Hypokalemia and alkalosis are seen in...
|
ectopic ACTH syndrome and adrenal carcinoma
|
|
|
The primary goal of collaborative care for Cushing is...
|
normalizing hormone secretion
|
|
|
Treatments of Cushing depends are the cause..
|
Pituitary adenoma: surgical removal of tumor/radiation
adrenal tumors/hyperplasia: adrenalectomy ectopic ACTH-secreting tumors: managed by treating primary neoplasm |
|
|
Common side effects of drug therapy include...
|
anorexia, n/v, GI bleeding, depression, vertigo, skin rashes, diplopia
|
|
|
What three things you can do if cushing syndrome develops?
|
Gradually d/c therapy
Decrease dose Convert to alternate-day regimen * Gradual tapering avoids potentially life threatening adrenal insufficiency |
|
|
In postoperative care, these are indications of hypocortisolism:
|
vomiting
increased weakness dehydration hypotension |
|
|
In postop care, patient may complain of:
|
painful joints
pruiritus peeling skin severe emotional disturbances. |
|
|
At home the patient should
|
wear MedicAlert bracelet
avoid exposure to stress, extremes of temperature, and infections lifetime therapy is required for many. |
