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22 Cards in this Set
- Front
- Back
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Lactotroph hyperfunction
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Prolactinemia, amenorrhea, galactorrhea, ↓libido, infertility
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Lactotroph hypofunction
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Failure of post-partum lactation
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Somatotroph hyperfunction - Child vs. adult
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↑GH, IGF0I; Child – gigantism, acromegaly; Adult – acromegaly, ↑bone density, jaw protrusion, CHF, gonadal dysfunction, DM, hypertension
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Somatotroph hypofunction (child only)
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Child - dwarfism
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Corticotroph hyperfunction
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↑ACTH, hyperpigmentation; see Cushing Syndrome below
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Corticotroph hypofunction
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Hypoadrenalism, pale skin
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Gonadotroph hyperfunction
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↑LH and/or FSH, no noticeable clinical symptoms
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Gonadotroph hypofunction
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↓LH, impotence and ↓libido ↓ hair (men), infertility and amenorrhea (women)
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Thyrotroph hyperfunction
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↓LH, impotence and ↓libido ↓ hair (men), infertility and amenorrhea (women)
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Thyrotroph hypofunction
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Hypothyroidism
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Post. pituitary hyperfunction (ADH)
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Water retention, ↓Na+/osmolality, normal blood volume, neurologic dysfunction, cerebral edema
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Post. pituitary hypofunction (ADH)
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Post. pituitary hyperfunction (ADH)
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Thyroid follicular hyperfunction
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Grave's disease
↑T3, T4, ↓TSH, ↑basal metabolic rate, ↓weight, heat intolerant ↓weight, heat intolerant, soft, warm, flush skin, ↑cardiac output, A. fib, tachycardia, ↑symp. NS, anxiety, insomnia, CHF, musmuscle weakness, osteoporosis, ophthalmopathy, malabsorption, fine hair |
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Thyroid follicular hypofunction - child vs. adult
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Hashimoto's - ↓T3, T4, ↑TSH
Cretinism (child) Myxedema (adult) ↓basal metabolic rate, ↑weight, cold intolerant, fatigue, ↓symp. NS, depression, SOB, mental sluggishness, constipation, dry, cool skin, coarse, brittle hair |
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Thyroid C-cells hyperfunction
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↑Calcitonin, normal Ca2+, diarrhea
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Parathyroid hyperfunction
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Asymptomatic, ↑Ca2+ and PTH, bone disease, hypophostphatemia, nausea, nephrolithiasis, constipation, peptic ulcers, depression, seizures, metastatic calcification, weakness, fatigue
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Parathyroid hypofunction
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↓Ca2+, tetany, numbness, paresthesias, depression, anxiety, ↑intracranial pressure, dental abnormalities (child), psychosis, cataracts, prolonged QT interval
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Zona Glomerulosa hyperfunction (aldosterone)
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↑Na+, hypertension, hypokalemia, ↓in 1º (↑in 2º) serum renin
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Zona Fasciculata hyperfunction (cortisol)
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Cushing syndrome - ↑weight, moon facies, truncal obesity, amenorrhea, hypertension, buffalo hump, hyperglycemia, secondary diabetes, osteoporosis, abdominal striae, immune suppression
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Zona Reticularis hyperfunction (androgens)
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Hypotension, ↓cortisol and aldosterone, masculinization (women), enlarged ext. genitalia and precocious puberty (males)
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Adrenal destruction - hypofunction
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Only occurs after ~90% destruction of adrenals!
Addison disease - ↓GCs, ↓MCs, progressive weakness, fatigue, anorexia, nausea, vomiting, weight loss, diarrhea, hyperpigmentation (if ↑ACTH- 1º), hyponatremia, hyperkalemia, ↓blood volume, hypotension, hypoglycemia |
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Chromaffin cell hyperfunction (adrenal medulla)
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Episodic Hypertension, perspiration,
catecholamine cardiomyopathy |
