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5 Cards in this Set
- Front
- Back
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Effect of ATP and ADP on OP:
ATP synthesis is controlled by what? How is ATP synthesis different in brown fat? |
ADP - promotes OP; ATP - stops OP - ATP synthesis/e- transport is coupled - ATP synthase inactive, no transport
ATP usage - (ADP formation) ATP formation is uncoupled, e- transport continues even w/ high ATP levels - regulated by thermogenin |
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What is the effect of stopping e- transport?
What is are the limiting factors in OP? |
NADH levels go up, decreased activity of energy pathways
high levels of ATP, O2 |
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What happens in Leber's hereditary optic neuropathy?
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mitochondrial defect in Complex I decreases ATP below level needed to sustain nerves - CN II
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Role of PPP?
Redox and interconversion stages makes what? |
generate riboses --> DNA/RNA synthesis
produces NADPH - biosynthesis of FA's, cholesterol, steroids, bile salts; detox in the liver, reduce glutathione in the RBC's Redox - R-5-P, NADPH Interconversion - R-5-P --> glycolytic intermediates |
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What is the key enzyme in the PPP?
What can cause G6PD deficiency? What happens? |
G-6-PD
fava beans, Sulfa, primaquine, XLR trait - G6PD deficiency means decreased levels of NADPH, which keeps glutathione in reduced state; deficiency means more ROS damage to RBC's |
