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11 Cards in this Set
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General effects of TH on growth:
Describe hypothyroid fetus born to hypothyroid/euthyroid mother: |
affects skeletal maturation, neurologic development, growth/development of cochlea
euthyroid mother - treat promptly, better chance of normal development hypothyroid mother - less treatable after birth, mental retardation more probable |
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Describe DTR time in hypo/hyperthyroid:
TH's effect on BMR: |
hypo - reaction time increased
hyper - reaction time decreased calorigenic, increases heat production - increases membrane permeability to Na+, Na+/K+ pump increases carb metabolism, glucose absorption, lipid metabolism |
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TH's effect on CV, GI:
Major symptoms of hypothyroid: |
increased HR, contractility , vasodilation, GI motility, digestive enzyme secretion
reduced BMR, cold intolerance, weight gain, cool/dry skin, coarse hair, hoarse voice, fatigue, decreased reflexes, myxedema, constipation, infertility |
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Major symptom of hyperthyroid:
Most useful lab values for thyroid diagnosis: Explain total T3/T4 and resin uptake values to determine hormone levels: |
elevated BMR, heat intolerance, warm skin, perspiration, nervousness, tremor, tachycardia, arrhythmia
Free T3, T4 low resin/serum ratio --> low free hormones high resin/serum ratio --> high free hormones |
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Explain cold and hot nodules in RAIU:
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active - will take up iodine more readily than non-functioning gland
hot nodule - takes up I more easily than cold nodule cold nodule - more malignant |
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Major S/S of cretinism (congenital hypothyroidism):
Autoimmune destruction of thyroid in adults, most common in US: Pathology? Initial stages of this disease can be associated with what? |
dwarfism, mental retardation, puffy face/edema, decreased bone development/maturation
Hashimoto's disease lymphocytic infiltration of thyroid gland causes destruction some hyperthyroid |
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Lab values for TSH, T3, T4 in primary hypothyroid:
Tx: Secondary hypothyroid is due to what? Lab values? If the lesion is confined to the anterior pituitary, will TRH be elevated or decreased? |
high TSH, low T3, T4
thyroxine lesion in anterior pituitary - low TSH, T3, T4 TRH will be elevated |
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Predominant type of hyperthyroid, caused by diffuse toxic goiter:
Pathology? Lab values? Symptoms? Tx? |
Grave's Disease
TSI's bind to TSH receptor, mimic action; low TSH, high T3, T4 exophthalmos, hyperthyroid S/S antithyroid drugs (thyroid peroxidase inhibitors) - thiopropyluracil, methimazole surgery, RAI |
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Caused by benign adenoma of thyroid, low TSH, excess T3, T4:
Type III deiodinase deficiency, T4 levels normal, but hypothyroid S/S: Lab values? Tx? |
Plummer's
euthyroid sick syndrome normal TSH, T4 levels low T3, rT3 treat illness causing it |
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Pathology of thyrotoxicosis:
Clinical presentation: Major concern/complication? |
thyroid hormones increase adrenergic receptors --> stress causes catecholamine release (increased hyperthyroid response)
hypermetabolism, fever, flushing, tachycardia, CNS agitation, N/V/D cardiac arrest |
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Eponym for antithyroid action of high [I], can be used to short-term tx of hyperthyroid:
Three major test categories for thyroid fxn: |
Wolff-Chaikoff effect - inhibits organic binding of I, reduces TSH-mediated cAMP increase
RAIU stimulation for hypothyroid suppression for hyperthyroid |
