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18 Cards in this Set
- Front
- Back
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MOA: metyrapone
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inhibits 11-hydroxylase, resulting in cortisol-synthesis inhibition
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MOA: aminoglutethimide
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inhibits conversion of cholesterol to pregnenolone early in cortisol pathway
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MOA: ketoconazole
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inhibits CYP450, 11-hydroxylase, & 17-hydroxylase
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MOA: etomidate
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inhibits 11-hydrylase, resulting in cortisol-synthesis inhibition
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MOA: mitotane
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inhibits cortisol & corticosterone synthesis in cortex
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MOA: cyproheptadine
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decrease ACTH secretion
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MOA: mifepristone (RU-486)
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progesterone & glucocorticoid receptor antagonist
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MOA: spironolactone
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competitively inhibits aldosterone
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MOA: eplerenone
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selectively inhibits aldosterone
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AE: metyrapone (7)
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nausea
vomiting vertigo headache dizziness abdominal discomfort allergic rash |
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AE: aminoglutethimide (6)
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dose dependent
severe sedation nausea ataxia skin rashes ↓ warfarin |
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AE: ketoconazole (4)
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gynecomastia
↓ plasma testosterone reversible ↑ LFT GI upset |
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AE: etomidate
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severe adrenal suppression
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AE: mitotane (3)
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lethargy
somnolence other CNS effects |
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AE: cyproheptadine (2)
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minor sedation
hyperphagia |
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AE: mifepristone (RU-486)
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abortions
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AE: spironolactone (5)
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GI discomfort
impotence gynecomastia menstrual irregularities salicylates ↑ free fraction |
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AE: eplerenone (5)
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GI discomfort
impotence * less gynecomastia menstrual irregularities OK with salicylates |
