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24 Cards in this Set

  • Front
  • Back
pituitary hormones are what kind of stucture? exceptions?
Peptides

GH, gonadotropins
when LH hits its its receptor, what does it activate?
Gs

adenylyl cyclase
What does LH do in the Ovary?
– promotes ovulation and luteinization of ovarian follicles;
stimulates synthesis and secretion of estrogen and progesterone from corpus luteum
What does LH do in males?
hits Leydig cells to secrete androgens (testosterone)
Clinical use of LH?
Infertility
What is lutropin?
LH
side effect of using LH/FSH (they are normally used in combo) in females? 2
Multiple pregnancies (4+ children)

Hyperstimulation of ovary (can cause ascites, pleural effusion, shock)---OHSS
What is Follitropin?
FSH
Physiological actions of FSH? (mech, ovary, testis)
Mechanism – activates Gs

Ovary – promote follicular development

Testis – stimulate testicular growth and maintain seminiferous tubules
adverse effects of follitropin?
OHS, multiple pregnancies

OHS=Hyperstimulation of ovary (can cause ascites, pleural effusion, shock)
hCG acts just like what?
LH
what is choriogonadotropin
hCG
actions of choriogonadotropin
this is hCG

stimulate and sustain function of corpus luteum (progesterone maintenance)
clinical application of choriogonadotropin (in men/females) 3
induction of ovulation,

promote descent of testes in cryptorchism

male infertility
how does hCG help Manny be Manny?
hCG used to re-start testosterone synthesis after using anabolic steroids.
histrelin, leuprolide, gosrelin, triptoreline, and nafareline are what kind of drugs?
GnRH
Leuprolide is what kind of drug?
GnRH
how does leuprolide affect LH/FSH levels
GnRH is normally pulsatory

this drug is long acting and NOT pulsatory (so initially you have an increase release of LH/FSH)

after a few days the receptors downregulate and you end up seeing DECREASED release of LH/FSH
Uses for GnRH analogs? 4
PMS

endometriosis: growth of endometrial tissue outside of the uterus (dependent on ESTROGEN for growth, these drugs will decrease FSH/LH and thus Estrogen, and fix the problem)

prostate cancer

central precocious puberty

note: leuprolide was an example of a GnRH analog
GnRH analogs are actually used as antagonists, what is important to remember though?
Even though they are used as antagonists, analogs initially cause increased gonadotropin release.

(later you will see a down regulation of receptors to lower gonadotropin effect)
What does ganirelix do?
GnRH antagonist
use of ganirelix?
GnRH antagonist

Used to inhibit premature LH surges prior to harvesting eggs for in vitro fertilization
abarelix and degarelix are what kind of drugs? use?
GnRH antagonists

used for Prostate cancer
with prolonged use, what problem do you need to consider with GnRH drugs?
can lead to menopause earlier in life