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24 Cards in this Set
- Front
- Back
pituitary hormones are what kind of stucture? exceptions?
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Peptides
GH, gonadotropins |
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when LH hits its its receptor, what does it activate?
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Gs
adenylyl cyclase |
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What does LH do in the Ovary?
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– promotes ovulation and luteinization of ovarian follicles;
stimulates synthesis and secretion of estrogen and progesterone from corpus luteum |
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What does LH do in males?
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hits Leydig cells to secrete androgens (testosterone)
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Clinical use of LH?
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Infertility
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What is lutropin?
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LH
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side effect of using LH/FSH (they are normally used in combo) in females? 2
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Multiple pregnancies (4+ children)
Hyperstimulation of ovary (can cause ascites, pleural effusion, shock)---OHSS |
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What is Follitropin?
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FSH
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Physiological actions of FSH? (mech, ovary, testis)
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Mechanism – activates Gs
Ovary – promote follicular development Testis – stimulate testicular growth and maintain seminiferous tubules |
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adverse effects of follitropin?
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OHS, multiple pregnancies
OHS=Hyperstimulation of ovary (can cause ascites, pleural effusion, shock) |
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hCG acts just like what?
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LH
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what is choriogonadotropin
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hCG
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actions of choriogonadotropin
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this is hCG
stimulate and sustain function of corpus luteum (progesterone maintenance) |
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clinical application of choriogonadotropin (in men/females) 3
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induction of ovulation,
promote descent of testes in cryptorchism male infertility |
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how does hCG help Manny be Manny?
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hCG used to re-start testosterone synthesis after using anabolic steroids.
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histrelin, leuprolide, gosrelin, triptoreline, and nafareline are what kind of drugs?
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GnRH
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Leuprolide is what kind of drug?
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GnRH
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how does leuprolide affect LH/FSH levels
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GnRH is normally pulsatory
this drug is long acting and NOT pulsatory (so initially you have an increase release of LH/FSH) after a few days the receptors downregulate and you end up seeing DECREASED release of LH/FSH |
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Uses for GnRH analogs? 4
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PMS
endometriosis: growth of endometrial tissue outside of the uterus (dependent on ESTROGEN for growth, these drugs will decrease FSH/LH and thus Estrogen, and fix the problem) prostate cancer central precocious puberty note: leuprolide was an example of a GnRH analog |
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GnRH analogs are actually used as antagonists, what is important to remember though?
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Even though they are used as antagonists, analogs initially cause increased gonadotropin release.
(later you will see a down regulation of receptors to lower gonadotropin effect) |
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What does ganirelix do?
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GnRH antagonist
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use of ganirelix?
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GnRH antagonist
Used to inhibit premature LH surges prior to harvesting eggs for in vitro fertilization |
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abarelix and degarelix are what kind of drugs? use?
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GnRH antagonists
used for Prostate cancer |
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with prolonged use, what problem do you need to consider with GnRH drugs?
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can lead to menopause earlier in life
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