Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
4 Cards in this Set
- Front
- Back
|
Describe the distribution of LDL Receptors.
|
-on virtually all nucleated cells - especially those which require a lot of cholesterol (adrenal cells, gonadal cells)
|
|
|
LDL-R's are only expressed when cells require cholesterol. True or false?
|
True
|
|
|
What can lead to a down-regulation of LDL-receptors?
|
-high dietary saturated fat
-entry of cholesterol into cells via LDL-receptors (negative feedback) |
|
|
How does LDL-R binding to its ligand affect endogenous cholesterol synthesis?
|
-ligands for LDL-R's are apo B100 and apo E
-when these ligands bind to LDL R's the CE's in the core of the LDL are hydrolysed to free cholesterol -free cholesterol down-regulates HMG-CoA reductase thus decreasing cholesterol synthesis |
