Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
13 Cards in this Set
- Front
- Back
|
Why is visceral obesity more deleterious than subcutaneous fat?
|
Triglicerides released from viceral adipocytes travel directly through the portal system to the liver, increases VLDL synthesis, and increases serum TG levels.
|
|
|
What effect does ghrelin have on appetite?
|
Ghrelin strongly stimulates eating behaviors in both rodents and humans.
|
|
|
What is a major function of leptin?
|
Leptin is a key negative feedback signal of body fat mass to areas of the brain that control appetite and energy expenditure.
|
|
|
What are the two hunger-promoting hypothalamic hormones?
|
NPY and AGRP
|
|
|
What is the anorexia-promoting hypothalamic hormone?
|
POMC
|
|
|
What are the components of the total daily energy expenditure?
|
1) Resting metabolic rate
2) Thermic effect of exercise 3) Dietary thermogenesis |
|
|
What is the major determinant of the resting metabolic rate?
|
Fat-free mass.
|
|
|
What is the major determinant of the thermic effect of exercise?
|
Voluntary and involuntary physical activity.
|
|
|
What is the major determinant of dietary thermogenesis?
|
Food intake.
|
|
|
Obesity is due to
|
an allelic variation in a variety of genes controlling energy balance.
|
|
|
What diet hormone is elevated in most obese individuals?
|
Leptin levels are high in most obese individuals, promoting the hypothesis of "leptin resistance."
|
|
|
What are the two main hypotheses about the obesity epidemic?
|
1) Food supply -> palatable foods -> neurologic addiction.
2) CNS development altered during fetal/neonatal life. |
|
|
Aside from surgery, what is the most effective strategy for durable weight loss?
|
Dietary fat restriction and regular exercise are the most effective weigh loss strategies we know.
|
